Search Results - "Landry, Matthew L."

Catalytic Enantioselective Dihalogenation in Total Synthesis by Landry, Matthew L, Burns, Noah Z

“…Conspectus To date, more than 5000 biogenic halogenated molecules have been characterized. This number continues to increase as chemists explore chloride- and…”
Get full text

Catalytic Enantioselective Dihalogenation and the Selective Synthesis of (−)-Deschloromytilipin A and (−)-Danicalipin A by Landry, Matthew L, Hu, Dennis X, McKenna, Grace M, Burns, Noah Z

“…A titanium-based catalytic enantioselective dichlorination of simple allylic alcohols is described. This dichlorination reaction provides stereoselective…”
Get full text

LogD Contributions of Substituents Commonly Used in Medicinal Chemistry by Landry, Matthew L, Crawford, James J

“…The importance of physicochemical property calculation and measurement is well-established in drug discovery. In particular, lipophilicity predictions play a…”
Get full text

Enantioselective Synthesis of Azamerone by Landry, Matthew L, McKenna, Grace M, Burns, Noah Z

“…A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of…”
Get full text

Log D Contributions of Substituents Commonly Used in Medicinal Chemistry by Landry, Matthew L, Crawford, James J

“…The importance of physicochemical property calculation and measurement is well-established in drug discovery. In particular, lipophilicity predictions play a…”
Get full text

When Cofactors Aren’t X Factors: Functional Groups That Are Labile in Human Liver Microsomes in the Absence of NADPH by Landry, Matthew L, Trager, Richard, Broccatelli, Fabio, Crawford, James J

“…The metabolic stability of compounds is often assessed at an early stage in drug discovery programs by profiling with hepatic microsomes. Exclusion of the…”
Get full text

Strategies to Mitigate the Bioactivation of Aryl Amines by Zhang, Chenghong, Crawford, James J, Landry, Matthew L, Chen, Huifen, Kenny, Jane R, Khojasteh, S. Cyrus, Lee, Wendy, Ma, Shuguang, Young, Wendy B

“…The bioactivation of xenobiotics to yield reactive metabolites can lead to tolerability and toxicity concerns within a drug discovery program. Development of…”
Get full text

Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design by Crawford, James J., Feng, Jianwen, Brightbill, Hans D., Johnson, Adam R., Wright, Matthew, Kolesnikov, Aleksandr, Lee, Wendy, Castanedo, Georgette M., Do, Steven, Blaquiere, Nicole, Staben, Steven T., Chiang, Po-Chang, Fan, Peter W., Baumgardner, Matt, Wong, Susan, Godemann, Robert, Grabbe, Alice, Wiegel, Catharina, Sujatha-Bhaskar, Swathi, Hymowitz, Sarah G., Liau, Nicholas, Hsu, Peter L., McEwan, Paul A., Ismaili, Moulay Hicham Alaoui, Landry, Matthew L.

“…[Display omitted] Inhibition of NF-κB inducing kinase (NIK) has been pursued as a promising therapeutic target for autoimmune disorders due to its highly…”
Get full text

Simple Syntheses of CdSe Quantum Dots by Landry, Matthew L, Morrell, Thomas E, Karagounis, Theodora K, Hsia, Chih-Hao, Wang, Chia-Ying

“…Quantum dots are an excellent resource for demonstrating quantum phenomena. Two new methods for synthesizing quantum dots are presented. Proceeding at…”
Get full text

Halogenation-Dependent Effects of the Chlorosulfolipids of Ochromonas danica on Lipid Bilayers by Moss III, Frank R, Cabrera, Gabrielle E, McKenna, Grace M, Salerno, Giulio J, Shuken, Steven R, Landry, Matthew L, Weiss, Thomas M, Burns, Noah Z, Boxer, Steven G

“…The chlorosulfolipids are amphiphilic natural products with stereochemically complex patterns of chlorination and sulfation. Despite their role in toxic…”
Get full text

Synthesis and Biophysical Characterization of the Chlorosulfolipids of Ochramonas danica by McKenna, Grace M., Moss, Frank R., Landry, Matthew L., Burns, Noah Z., Boxer, Steven G.

Get full text