Search Results - "Landry, J. P."

High-Throughput Dose–Response Measurement Using a Label-Free Microarray-in-Microplate Assay Platform by Landry, J. P, Malovichko, G, Zhu, X. D

“…Microarray-based binding assays facilitate the discovery of protein ligands from large collections of small molecules. Hundreds of ligands can be identified,…”
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Effect of Fluorescently Labeling Protein Probes on Kinetics of Protein−Ligand Reactions by Sun, Y. S, Landry, J. P, Fei, Y. Y, Zhu, X. D, Luo, J. T, Wang, X. B, Lam, K. S

“…We studied the effect of fluorescently labeling proteins on protein−ligand reactions. Unlabeled ligands (streptavidin-binding peptides and rabbit…”
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Protein reactions with surface-bound molecular targets detected by oblique-incidence reflectivity difference microscopes by Landry, J P, Sun, Y S, Guo, X W, Zhu, X D

“…We applied oblique-incidence reflectivity difference microscopes (a form of polarization-modulated nulling ellipsometry) to detection of biomolecular…”
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Macromolecular Scaffolds for Immobilizing Small Molecule Microarrays in Label-Free Detection of Protein−Ligand Interactions on Solid Support by Sun, Y. S, Landry, J. P, Fei, Y. Y, Zhu, X. D, Luo, J. T, Wang, X. B, Lam, K. S

“…We explored two macromolecular scaffolds, bovine serum albumin (BSA) and polyvinyl alcohol (PVA), as chemically complementary platforms for immobilizing small…”
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A novel high-throughput scanning microscope for label-free detection of protein and small-molecule chemical microarrays by Fei, Y Y, Landry, J P, Sun, Y S, Zhu, X D, Luo, J T, Wang, X B, Lam, K S

“…We describe a novel scanning optical microscope based on a polarization-modulated nulling ellipsometry. The new microscope employs a combination of scanning…”
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Measuring affinity constants of 1450 monoclonal antibodies to peptide targets with a microarray-based label-free assay platform by Landry, J.P., Ke, Yaohuang, Yu, Guo-Liang, Zhu, X.D.

“…Monoclonal antibodies (mAbs) are major reagents for research and clinical diagnosis. For their inherently high specificities to intended antigen targets and…”
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Label-free detection of microarrays of biomolecules by oblique-incidence reflectivity difference microscopy by Landry, J P, Zhu, X D, Gregg, J P

“…We developed an oblique-incidence reflectivity difference (OI-RD) scanning microscope for label-free imaging of microarrays of biomolecules upon solid…”
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Drug-induced hiccups by Thompson, D F, Landry, J P

“…Pharmacotherapeutic agents are uncommonly associated with hiccups. Corticosteroids and benzodiazepines have been the drug classes mentioned most frequently in…”
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Scanning tunneling microscopy study of the molecular arrangement of meta- and para-xylene on Pd(111) by Futaba, D. N., Landry, J. P., Loui, A., Chiang, S.

“…We have performed an experimental study of meta- and para-xylene isomers, C 6 H 4 (CH 3 ) 2 , adsorbed on Pd(111). Using scanning tunneling microscopy we…”
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Incidence-angle dependence of optical reflectivity difference from an ultrathin film on solid surface by Landry, J P, Gray, J, O'Toole, M K, Zhu, X D

“…We studied the incidence-angle dependence of the optical reflectivity difference in response to ultrathin films on transparent and opaque substrates. We found…”
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Simultaneous measurement of 10,000 protein-ligand affinity constants using microarray-based kinetic constant assays by Landry, James P, Fei, Yiyan, Zhu, Xiangdong

“…Fluorescence-based endpoint detection of microarrays with 10,000 or more molecular targets is a most useful tool for high-throughput profiling of biomolecular…”
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Measuring Affinity Constants of 1,450 Monoclonal Antibodies to Peptide Targets with a Microarray-based Label-Free Assay Platform by Landry, J. P., Ke, Yaohuang, Yu, Guo-Liang, Zhu, X. D.

“…Monoclonal antibodies (mAbs) are major reagents for research and clinical diagnosis. For their inherently high specificities to intended antigen targets and…”
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Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical reactions in a microarray format by Zhu, Xiangdong, Landry, James P, Sun, Yung-Shin, Gregg, Jeff P, Lam, Kit S, Guo, Xiaowen

“…We describe a recently developed oblique-incidence reflectivity difference (OI-RD) microscope, a form of polarization-modulated imaging ellipsometer, for…”
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Use of severity adjusted comparative systems in the development of critical pathways by Landry, P J

“…This paper has been prepared to present how South Shore Hospital has successfully used computerized applications to provide the highest quality patient care in…”
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Pharmacy-coordinated, multidisciplinary adverse drug reaction program by Swanson, K M, Landry, J P, Anderson, R P

“…To date, the stated program objectives have been met. There is a heightened awareness of ADRs, and the program has had a positive impact on patient care. More…”
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High-Throughput Endpoint and Real-Time Detection of Biochemical Reactions in Microarrays Using Label-Free Oblique-Incidence Reflectivity Difference Microscopes by Landry, J.P., Sun, Y.S., Lam, K.S., Zhu, X.D.

“…We describe recently developed oblique-incidence reflectivity difference microscopes, a form of polarization-modulated imaging ellipsometry, for label-free…”
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Label-free optical detection of biomolecular reaction kinetics in microarray format for high-throughput screening applications by Sun, Y.S., Landry, J.P., Fei, Y.Y., Luo, J.T., Lam, K.S., Zhu, X.D.

“…Using a combination of an oblique-incidence reflectivity difference (OI-RD) scanning microscope and a customized 8-chamber sample cartridge, we detect 300…”
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High-throughput screening of small-molecule microarrays with label-free optical scanning microscope by Fei, Y.Y., Landry, J.P., Sun, Y.S., Wang, X.B., Luo, J.T., Lam, K.S., Zhu, X.D.

“…We investigated surface chemistry platforms for immobilizing two types of synthetic, small-molecule compound libraries, each with over 6000 compounds, and for…”
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High-throughput protein binding end-points and kinetics in microarrays using label-free OI-RD microscopes by Landry, J.P., Sun, Y.S., Fei, Y.Y., Lam, K.S., Zhu, X.D.

“…The potential of biomolecular microarrays on glass for high-throughput kinetics assays has not previously been fully exploited. We demonstrate real-time…”
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High-throughput microscope for label-free detection of protein and small-molecule chemical microarrays by Fei, Y.Y., Landry, J.P., Sun, Y.S., Luo, J.T., Wang, X.B., Lam, K.S., Zhu, X.D.

“…We describe a novel scanning optical microscope that enables high-throughput label-free detection of end-points and kinetics of multiple biomolecular reactions…”
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