Search Results - "Landrette, Sean F."

Low-copy piggyBac transposon mutagenesis in mice identifies genes driving melanoma by Ni, Thomas K, Landrette, Sean F, Bjornson, Robert D, Bosenberg, Marcus W, Xu, Tian

“…Despite considerable efforts to sequence hypermutated cancers such as melanoma, distinguishing cancer-driving genes from thousands of recurrently mutated genes…”
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Somatic genetics empowers the mouse for modeling and interrogating developmental and disease processes by Landrette, Sean F, Xu, Tian

“…With recent advances in genomic technologies, candidate human disease genes are being mapped at an accelerated pace. There is a clear need to move forward with…”
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Characterization of fluorescent eye markers for mammalian transgenic studies by Cornett, Jonathan C, Landrette, Sean F, Xu, Tian

“…Genotyping mice by DNA based methods is both laborious and costly. As an alternative, we systematically examined fluorescent proteins expressed in the lens as…”
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piggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice by Landrette, Sean F, Cornett, Jonathan C, Ni, Thomas K, Bosenberg, Marcus W, Xu, Tian

“…Somatic forward genetic screens have the power to interrogate thousands of genes in a single animal. Retroviral and transposon mutagenesis systems in mice have…”
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Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors by Choi, Jaehyuk, Landrette, Sean F., Wang, Tiffany, Evans, Perry, Bacchiocchi, Antonella, Bjornson, Robert, Cheng, Elaine, Stiegler, Amy L., Gathiaka, Symon, Acevedo, Orlando, Boggon, Titus J., Krauthammer, Michael, Halaban, Ruth, Xu, Tian

“…Summary BRAF inhibitors improve melanoma patient survival, but resistance invariably develops. Here we report the discovery of a novel BRAF mutation that…”
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Cbfβ-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia by Kuo, Ya-Huei, Landrette, Sean F., Heilman, Susan A., Perrat, Paola N., Garrett, Lisa, Liu, Pu P., Le Beau, Michelle M., Kogan, Scott C., Castilla, Lucio H.

“…The acute myeloid leukemia (AML)-associated CBFβ-SMMHC fusion protein impairs hematopoietic differentiation and predisposes to leukemic transformation. The…”
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Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11 by Landrette, Sean F., Kuo, Ya-Huei, Hensen, Karen, van Waalwijk van Doorn-Khosrovani, Sahar Barjesteh, Perrat, Paola N., Van de Ven, Wim J.M., Delwel, Ruud, Castilla, Lucio H.

“…Recurrent chromosomal rearrangements are associated with the development of acute myeloid leukemia (AML). The frequent inversion of chromosome 16 creates the…”
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Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes: e1002110 by Landrette, Sean F, Xu, Tian

“…With recent advances in genomic technologies, candidate human disease genes are being mapped at an accelerated pace. There is a clear need to move forward with…”
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Low-copy piggyBac transposon mutagenesis in mice identifies genes driving melanoma by Ni, Thomas K., Landrette, Sean F., Bjornson, Robert D., Bosenberg, Marcus W., Xu, Tian

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The PlagL2 transcription factor activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells by Landrette, Sean F, Madera, Dmitri, He, Feng, Castilla, Lucio H

“…Cytokine signaling pathways are frequent targets of oncogenic mutations in acute myeloid leukemia, promoting proliferation and survival. We have previously…”
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piggyBac Transposon Somatic Mutagenesis with an Activated Reporter and Tracker by Landrette, Sean F, Cornett, Jonathan C, Ni, Thomas K, Bosenberg, Marcus W, Xu, Tian

“…Somatic forward genetic screens have the power to interrogate thousands of genes in a single animal. Retroviral and transposon mutagenesis systems in mice have…”
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Identification of PLX 4032‐resistance mechanisms and implications for novel RAF inhibitors by Choi, Jaehyuk, Landrette, Sean F., Wang, Tiffany, Evans, Perry, Bacchiocchi, Antonella, Bjornson, Robert, Cheng, Elaine, Stiegler, Amy L., Gathiaka, Symon, Acevedo, Orlando, Boggon, Titus J., Krauthammer, Michael, Halaban, Ruth, Xu, Tian

“…BRAF inhibitors improve melanoma patient survival, but resistance invariably develops. Here we report the discovery of a novel BRAF mutation that confers…”
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PLAGL2 Cooperates in Leukemia Development by Direcly Inducing c-Mpl Expression by Landrette, Sean F., Castilla, Lucio H.

“…Inversion of chromosome 16 is found in 12% of human acute myeloid leukemia (AML). This inversion creates the CBFΒ-SMMHC fusion protein, which hinders myeloid…”
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Plag1 and Plag12 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11 by LANDRETTE, Sean F, KUO, Ya-Huei, HENSEN, Karen, VAN WAALWIJK VAN DOORN-KHOSROVANI, Sahar Barjesteh, PERRAT, Paola N, VAN DE VEN, Wim J. M, DELWEL, Ruud, CASTILLA, Lucio H

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