Search Results - "Landon, E J"

Are Risk Evaluation and Mitigation Strategies Associated With Less Off-Label Use of Medications? The Case of Immune Thrombocytopenia by Sarpatwari, A, Franklin, JM, Avorn, J, Seeger, JD, Landon, JE, Kesselheim, AS

“…Using data from a large commercial health insurer, we studied prescribing of romiplostim (Nplate) and eltrombopag (Promacta), two drugs for primary immune…”
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Beyond the G Protein: The Saga of the Type 2 Angiotensin II Receptor by Landon, E J, Inagami, T

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Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells. Roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2 by Tang, H, Zhao, Z J, Landon, E J, Inagami, T

“…Calcium-sensitive tyrosine kinase Pyk2 has been implicated in the regulation of ion channels, cellular adhesion, and mitogenic and hypertrophic reactions. In…”
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A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy by Inagami, Tadashi, Senbonmatsu, Takaaki, Saito, Takako, Landon, Erwin J, Watanabe, Otsu, Price, Edward, Roberts, Richard L, Imboden, Hans, Fitzgerald, Trinita G, Gaffney, F.Andrew

“…We describe a novel signaling mechanism mediated by the G‐protein‐coupled receptor (GPCR) angiotensin II (Ang II) type 2 receptor (AT2). Yeast two‐hybrid…”
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Effect of dietary cardiac glycosides on blood pressure regulation in rats by Tamura, M, Utsunomiya, H, Nakamura, M, Landon, E J

“…To investigate the possible physiological significance of dietary cardiac glycosides in blood pressure regulation, the blood pressure of normal Sprague Dawley…”
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Intracellular Sodium Modulates the Expression of Angiotensin II Subtype 2 Receptor in PC12W Cells by Tamura, Masaaki, Wanaka, Yoshio, Landon, Erwin J, Inagami, Tadashi

“…Although the angiotensin II subtype 2 receptor (AT2-R) is expressed abundantly in the adrenal medulla, its physiological significance has not yet been…”
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Ouabain increases aldosterone release from bovine adrenal glomerulosa cells: role of renin-angiotensin system by Tamura, M. (Vanderbilt University School of Medicine, Nashville, TN.), Piston, D.W, Tani, M, Naruse, M, Landon, E.J, Inagami, T

“…To evaluate the potential physiological significance of ouabain or a ouabainlike substance, we investigated the effect of nanomolar concentrations of ouabain…”
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Lipopolysaccharides and cytokines downregulate the angiotensin II type 2 receptor in rat cardiac fibroblasts by Tamura, Masaaki, Chen, Yue-Jin, Howard, Eric F., Tanner, Miles, Landon, Erwin J., Myers, Paul R.

“…The present study examines the effect of lipopolysaccharides and proinflammatory cytokines on the expression of the second isoform of the angiotensin II…”
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Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents by Landon, E J, Naukam, R J, Rama Sastry, B V

“…Carbon tetrachloride, chloroform, dimethylnitrosamine, thioacetamide or acetaminophen was each administered to rats in a single hepatotoxic dose. Nifedipine,…”
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Energy-dependent calcium sequestration activity in rat liver microsomes by L Moore, T Chen, H R Knapp, Jr, E J Landon

“…MgATP-dependent calcium sequestering activity of rat liver microsomes has been characterized. This activity is linear over a 90-min period and specifically…”
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Na+,K+-ATPase Inhibitors in Rat Urine: Origins and Physiological Significance by Tamura, Masaaki, Landon, Erwin J., Inagami, Tadashi

“…To identify the origins and structures of mammalian tissue-derived Na+,K+-ATPase inhibitors, we investigated the tissue distribution of inhibitors in rats…”
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Calcium uptake of a rat liver microsomal subcellular fraction in response to in vivo administration of carbon tetrachloride by Moore, L, Rodman Davenport, G, Landon, E J

“…ATP-dependent calcium uptake of rat liver microsomes is examined following ingestion of CC14 (2.5 ml/kg). Within 30 min there is an abrupt drop in calcium…”
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3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors block calcium-dependent tyrosine kinase Pyk2 activation by angiotensin II in vascular endothelial cells. involvement of geranylgeranylation of small G protein Rap1 by Satoh, K, Ichihara, K, Landon, E J, Inagami, T, Tang, H

“…We recently reported the calcium-dependent activation of tyrosine kinase Pyk2 by angiotensin II (Ang II) in pulmonary vein endothelial cells (PVEC). Since Pyk2…”
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Inhibition of AT1 receptor internalization by concanavalin A blocks angiotensin II-induced ERK activation in vascular smooth muscle cells. Involvement of epidermal growth factor receptor proteolysis but not AT1 receptor internalization by Tang, H, Nishishita, T, Fitzgerald, T, Landon, E J, Inagami, T

“…Recent studies of beta(2)-adrenergic receptor suggest that agonist-promoted receptor internalization may play an important role in extracellular…”
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Effects of calcium channel blocking agents on membrane microviscosity and calcium in the liver of the carbon tetrachloride treated rat by Landon, E J, Jaiswal, R K, Naukam, R J, Sastry, B V

“…Membrane microviscosity was determined from the polarized fluorescence of diphenylhexatriene in plasma membranes and microsomes prepared from the liver of…”
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Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats by TAMURA, Masaaki, TAKAGI, Tetsuo, HOWARD, Eric F, LANDON, Erwin J, STEIMLE, Alan, TANNERY, Miles, MYERS, Paul R

“…Chronic feeding of a purified synthetic diet induces renin-angiotensin system-dependent moderate high blood pressure in normal Sprague-Dawley rats. The present…”
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Dithiothreitol-induced alterations of blood pressure, vascular reactivity and aortic microsomal calcium uptake in spontaneously hypertensive rats by Mushlin, P S, Sastry, B V, Boerth, R C, Surber, M J, Landon, E J

“…Dithiothreitol, a potent sulfhydryl reducing agent, depressed systolic blood pressure to a greater extent in genetically hypertensive rats (SHR) than in…”
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Methylation of phospholipids in microsomes of the rat aorta by Jaiswal, R K, Landon, E J, Sastry, B V

“…The methylation of phospholipids by S-adenosyl-L-methionine was characterized in microsomes prepared from strips of rat aorta. In the presence of 0.5 microM…”
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Effect of L-methionine on contractile response, calcium influx and calcium channel blocking agents in the rat aorta by Landon, E J, Owens, L, Sastry, B V

“…L-Methionine incubated with aorta strips and S-adenosyl-L-methionine incubated with aorta membranes methylate membrane phospholipids. L-Methionine enhances the…”
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Activities of 5-methylfurfuryltrimethylammonium iodide and related compounds at vascular endothelial muscarinic receptors of the rat aorta by Horst, M A, Sastry, B V, Landon, E J

“…5-Methylfurfuryltrimethylammonium iodide (5-MFT) is a furan analog of muscarine and was studied for its cholinergic activity at vascular endothelial receptors…”
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