Search Results - "Landis, Margaret S"

Pharmacokinetics and metabolism studies on the glucagon-like peptide-1 (GLP-1)-derived metabolite GLP-1(9-36)amide in male Beagle dogs by Eng, Heather, Sharma, Raman, McDonald, Thomas S., Landis, Margaret S., Stevens, Benjamin D., Kalgutkar, Amit S.

“…Abstract 1. Glucagon-like peptide-1 (GLP-1)(7-36)amide is a 30-amino acid peptide hormone that is secreted from intestinal enteroendocrine L-cells in response…”
Get full text

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide‑1 Receptor by Griffith, David A., Edmonds, David J., Fortin, Jean-Philippe, Kalgutkar, Amit S., Kuzmiski, J. Brent, Loria, Paula M., Saxena, Aditi R., Bagley, Scott W., Buckeridge, Clare, Curto, John M., Derksen, David R., Dias, João M., Griffor, Matthew C., Han, Seungil, Jackson, V. Margaret, Landis, Margaret S., Lettiere, Daniel, Limberakis, Chris, Liu, Yuhang, Mathiowetz, Alan M., Patel, Jayesh C., Piotrowski, David W., Price, David A., Ruggeri, Roger B., Tess, David A.

“…Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited because they require…”
Get full text

Commentary: Why Pharmaceutical Scientists in Early Drug Discovery Are Critical for Influencing the Design and Selection of Optimal Drug Candidates by Landis, Margaret S., Bhattachar, Shobha, Yazdanian, Mehran, Morrison, John

“…This commentary reflects the collective view of pharmaceutical scientists from four different organizations with extensive experience in the field of drug…”
Get full text

Stabilization of Pharmaceuticals to Oxidative Degradation by Waterman, Kenneth C., Adami, Roger C., Alsante, Karen M., Hong, Jinyang, Landis, Margaret S., Lombardo, Franco, Roberts, Christopher J.

“…A guide for stabilization of pharmaceuticals to oxidation is presented. Literature is presented with an attempt to be a ready source for data and…”
Get full text

Nasal-to-CNS drug delivery: where are we now and where are we heading? An industrial perspective by Landis, Margaret S, Boyden, Tracey, Pegg, Simon

“…Delivery of drug therapeutics across the blood-brain barrier is a challenging task for pharmaceutical scientists. Nasal-to-CNS drug delivery has shown…”
Get more information

Physicochemical property trends of marketed prodrugs by Landis, Margaret S

“…Many prodrug reviews describe specific examples of the successful application of prodrug technology to produce blockbuster drugs, such as simvastatin,…”
Get more information

Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylamino-piperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist by GRIFFITH, David A, HADCOCK, John R, O'CONNOR, Rebecca E, SCOTT, Dennis O, BLACK, Shawn C, IREDALE, Philip A, CARPINO, Philip A, DASILVA-JARDINE, Paul, DAY, Robert, DIBRINO, Joseph, DOW, Robert L, LANDIS, Margaret S

Get full text

Recent Trends in Product Development and Regulatory Issues on Impurities in Active Pharmaceutical Ingredient (API) and Drug Products. Part 2: Safety Considerations of Impurities in Pharmaceutical Products and Surveying the Impurity Landscape by Alsante, Karen M., Huynh-Ba, Kim C., Baertschi, Steven W., Reed, Robert A., Landis, Margaret S., Furness, Scott, Olsen, Bernard, Mowery, Mark, Russo, Karen, Iser, Robert, Stephenson, Gregory A., Jansen, Patrick

Get full text

The use of mixed-mode ion-exchange solid phase extraction to characterize pharmaceutical drug degradation by Landis, Margaret S.

“…Solid phase extraction (SPE) has been utilized extensively in the pharmaceutical industry for the isolation of pharmaceuticals from interfering biological…”
Get full text

Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist by Griffith, David A, Hadcock, John R, Black, Shawn C, Iredale, Philip A, Carpino, Philip A, DaSilva-Jardine, Paul, Day, Robert, DiBrino, Joseph, Dow, Robert L, Landis, Margaret S, O’Connor, Rebecca E, Scott, Dennis O

“…We report the structure−activity relationships, design, and synthesis of the novel cannabinoid type 1 (CB1) receptor antagonist 3a (CP-945,598). Compound 3a…”
Get full text

Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase by Kung, Daniel W., Griffith, David A., Esler, William P., Vajdos, Felix F., Mathiowetz, Alan M., Doran, Shawn D., Amor, Paul A., Bagley, Scott W., Banks, Tereece, Cabral, Shawn, Ford, Kristen, Garcia-Irizarry, Carmen N., Landis, Margaret S., Loomis, Kathrine, McPherson, Kirk, Niosi, Mark, Rockwell, Kristin L., Rose, Colin, Smith, Aaron C., Southers, James A., Tapley, Susan, Tu, Meihua, Valentine, James J.

“…[Display omitted] A novel series of spirocyclic-diamine based, isoform non-selective inhibitors of acetyl-CoA carboxylase (ACC) is described. These…”
Get full text

Photochemistry and Photophysics of α-Hydroxy Ketones by Jockusch, Steffen, Landis, Margaret S, Freiermuth, Beat, Turro, Nicholas J

“…Time-resolved laser flash spectroscopy with transient detection by time-resolved UV−vis, IR, and EPR has been employed to investigate the photochemistry and…”
Get full text

Recent Trends in Product Development and Regulatory Issues on Impurities in Active Pharmaceutical Ingredient (API) and Drug Products. Part 1: Predicting Degradation Related Impurities and Impurity Considerations for Pharmaceutical Dosage Forms by Alsante, Karen M., Huynh-Ba, Kim, Baertschi, Steven W., Reed, Robert A., Landis, Margaret S., Kleinman, Mark H., Foti, Christopher, Rao, Venkatramana M., Meers, Paul, Abend, Andreas, Reynolds, Daniel W., Joshi, Biren K.

Get full text

Hydrolysis in Pharmaceutical Formulations by Waterman, Kenneth C., Adami, Roger C., Alsante, Karen M., Antipas, Amy S., Arenson, Dan R., Carrier, Rebecca, Hong, Jinyang, Landis, Margaret S., Lombardo, Franco, Shah, Jaymin C., Shalaev, Evgenyi, Smith, Scott W., Wang, Hai

“…This literature review presents hydrolysis of active pharmaceutical ingredients as well as the effects on dosage form stability due to hydrolysis of…”
Get full text

Photo-Arbuzov rearrangements of cyclic phosphite systems by Landis, Margaret S, Turro, Nicholas J, Bhanthumnavin, Worawan, Bentrude, Wesley G

“…The direct UV irradiation of cyclic phosphites 1– 4 was carried out in argon-saturated solvents. In all cases examined, the rearranged, ring-contracted…”
Get full text

Studies of the regiospecific 3-aza-Cope rearrangement promoted by electrophilic reagents by Barta, Nancy S, Cook, Gregory R, Landis, Margaret S, Stille, John R

Get full text

The photo-Arbuzov reaction of cyclic phosphite systems by Landis, Margaret S

“…The photo-Arbuzov rearrangement of acyclic phosphites to acyclic phosphonates has been shown to occur for a variety of systems. This reaction represents an…”
Get full text

Supramolecular control of photochemical enantiomeric induction and radical pair recombination in zeolites by Kaprinidis, Nikolas A., Landis, Margaret S., Turro, Nicholas J.

“…Geminate radical pairs are formed from the α-photocleavage of aryl ketones within the supercage of zeolites which has been modified with chiral guest…”
Get full text

The photo-Arbuzov reaction of cyclic phosphite systems by Landis, Margaret S

“…The photo-Arbuzov rearrangement of acyclic phosphites to acyclic phosphonates has been shown to occur for a variety of systems. This reaction represents an…”
Get full text

Magnetic Field Dependence of the 31 P CIDNP in the Photolysis of a Benzyl Phosphite. Evidence for a T - −S Mechanism by Koptyug, Igor V., Sluggett, Gregory W., Ghatlia, Naresh D., Landis, Margaret S., Turro, Nicholas J., Ganapathy, Srinivasan, Bentrude, Wesley G.

Get full text