Search Results - "Landgraf, E."

Membrane docking geometry of GRP1 PH domain bound to a target lipid bilayer: an EPR site-directed spin-labeling and relaxation study by Chen, Huai-Chun, Ziemba, Brian P, Landgraf, Kyle E, Corbin, John A, Falke, Joseph J

“…The second messenger lipid PIP(3) (phosphatidylinositol-3,4,5-trisphosphate) is generated by the lipid kinase PI3K (phosphoinositide-3-kinase) in the inner…”
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Evidence that opioids may have toll-like receptor 4 and MD-2 effects by Hutchinson, Mark R, Zhang, Yingning, Shridhar, Mitesh, Evans, John H, Buchanan, Madison M, Zhao, Tina X, Slivka, Peter F, Coats, Benjamen D, Rezvani, Niloofar, Wieseler, Julie, Hughes, Travis S, Landgraf, Kyle E, Chan, Stefanie, Fong, Stephanie, Phipps, Simon, Falke, Joseph J, Leinwand, Leslie A, Maier, Steven F, Yin, Hang, Rice, Kenner C, Watkins, Linda R

“…Abstract Opioid-induced proinflammatory glial activation modulates wide-ranging aspects of opioid pharmacology including: opposition of acute and chronic…”
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An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides by Landgraf, Kyle E, Steffek, Micah, Quan, Clifford, Tom, Jeffrey, Yu, Christine, Santell, Lydia, Maun, Henry R, Eigenbrot, Charles, Lazarus, Robert A

“…Structure-guided peptide phage display combined with activity-based sorting results in the identification of zymogen activator peptides (ZAPtides) that…”
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An allosteric anti-hepsin antibody derived from a constrained phage display library by Ganesan, Rajkumar, Zhang, Yingnan, Landgraf, Kyle E., Lin, S.Jack, Moran, Paul, Kirchhofer, Daniel

“…The serine protease hepsin is highly upregulated in prostate cancer and is implicated in tumor progression. Therefore, specific inhibition of hepsin enzymatic…”
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Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling by Landgraf, Kyle E., Santell, Lydia, Billeci, Karen L., Quan, Clifford, Young, Judy C., Maun, Henry R., Kirchhofer, Daniel, Lazarus, Robert A.

“…Hepatocyte growth factor (HGF) binds to its target receptor tyrosine kinase, Met, as a single-chain form (pro-HGF) or as a cleaved two-chain disulfide-linked…”
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The GRP1 PH Domain, Like the AKT1 PH Domain, Possesses a Sentry Glutamate Residue Essential for Specific Targeting to Plasma Membrane PI(3,4,5)P3 by Pilling, Carissa, Landgraf, Kyle E, Falke, Joseph J

“…During the appearance of the signaling lipid PI(3,4,5)P3, an important subset of pleckstrin homology (PH) domains target signaling proteins to the plasma…”
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Charge trapping memory structures with Al2O3 trapping dielectric for high-temperature applications by SPECHT, M, REISINGER, H, HOFMANN, F, SCHULZ, T, LANDGRAF, E, LUYKEN, R. J, RÖSNER, W, GRIEB, M, RISCH, L

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Molecular Mechanism of an Oncogenic Mutation That Alters Membrane Targeting: Glu17Lys Modifies the PIP Lipid Specificity of the AKT1 PH Domain by Landgraf, Kyle E, Pilling, Carissa, Falke, Joseph J

“…The protein kinase AKT1 regulates multiple signaling pathways essential for cell function. Its N-terminal PH domain (AKT1 PH) binds the rare signaling…”
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A Non-immunogenic Bivalent d‑Protein Potently Inhibits Retinal Vascularization and Tumor Growth by Marinec, Paul S, Landgraf, Kyle E, Uppalapati, Maruti, Chen, Gang, Xie, Daniel, Jiang, Qiyang, Zhao, Yanlong, Petriello, Annalise, Deshayes, Kurt, Kent, Stephen B. H, Ault-Riche, Dana, Sidhu, Sachdev S

“…We report a general approach to engineering multivalent d-proteins with antibody-like activities in vivo. Mirror-image phage display and structure-guided…”
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Single-Molecule Studies Reveal a Hidden Key Step in the Activation Mechanism of Membrane-Bound Protein Kinase C‑α by Ziemba, Brian P, Li, Jianing, Landgraf, Kyle E, Knight, Jefferson D, Voth, Gregory A, Falke, Joseph J

“…Protein kinase C-α (PKCα) is a member of the conventional family of protein kinase C isoforms (cPKCs) that regulate diverse cellular signaling pathways, share…”
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convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting by Landgraf, Kyle E., Williams, Steven R., Steiger, Daniel, Gebhart, Dana, Lok, Stephen, Martin, David W., Roybal, Kole T., Kim, Kaman Chan

“…We have developed a chimeric antigen receptor (CAR) platform that functions as a modular system to address limitations of traditional CAR therapies. An inert…”
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Membrane Docking Geometry and Target Lipid Stoichiometry of Membrane-Bound PKCα C2 Domain: A Combined Molecular Dynamics and Experimental Study by Lai, Chun-Liang, Landgraf, Kyle E., Voth, Gregory A., Falke, Joseph J.

“…Protein kinase Cα (PKCα) possesses a conserved C2 domain (PKCα C2 domain) that acts as a Ca 2+-regulated membrane targeting element. Upon activation by Ca 2+,…”
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Influence of crystal orientation and body doping on trigate transistor performance by Landgraf, E., Rösner, W., Städele, M., Dreeskornfeld, L., Hartwich, J., Hofmann, F., Kretz, J., Lutz, T., Luyken, R.J., Schulz, T., Specht, M., Risch, L.

“…This work characterizes long channel trigate transistors with respect to the systematic influence of crystal orientation and body doping on performance issues…”
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Low power integrated pressure sensor system for medical applications by Hierold, C, Clasbrummel, B, Behrend, D, Scheiter, T, Steger, M, Oppermann, K, Kapels, H, Landgraf, E, Wenzel, D, Etzrodt, D

“…A new low power integrated pressure sensor system with digital output (1 bit PDM signal) for medical applications is presented. The absolute pressure sensor…”
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Planar and vertical double gate concepts by Schulz, T, Rösner, W, Landgraf, E, Risch, L, Langmann, U

“…In this paper, we report a comparative study of different double gate architectures. The main focus is on the fabrication method of two different device…”
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Mechanism of Specific Membrane Targeting by C2 Domains:  Localized Pools of Target Lipids Enhance Ca2+ Affinity by Corbin, John A, Evans, John H, Landgraf, Kyle E, Falke, Joseph J

“…The C2 domain is a ubiquitous, conserved protein signaling motif widely found in eukaryotic signaling proteins. Although considerable functional diversity…”
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Realization and characterization of nano-scale FinFET devices by KRETZ, J, DREESKORNFELD, L, SCHRÖTER, R, LANDGRAF, E, HOFMANN, F, RÖSNER, W

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Realization and characterization of nano-scale FinFET devices by Kretz, J., Dreeskornfeld, L., Schröter, R., Landgraf, E., Hofmann, F., Rösner, W.

“…The double gate transistor is regarded as the ultimate device for future CMOS technologies because the excellent channel control suppresses leakage currents…”
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Effect of PIP2 Binding on the Membrane Docking Geometry of PKCα C2 Domain: An EPR Site-Directed Spin-Labeling and Relaxation Study by Landgraf, Kyle E, Malmberg, Nathan J, Falke, Joseph J

“…Protein kinase C isoform alpha (PKCα) is a ubiquitous, conventional PKC enzyme that possesses a conserved C2 domain. Upon activation by cytoplasmic Ca2+ ions,…”
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Nanoscale FinFETs for low power applications by Rösner, W., Landgraf, E., Kretz, J., Dreeskornfeld, L., Schäfer, H., Städele, M., Schulz, T., Hofmann, F., Luyken, R.J., Specht, M., Hartwich, J., Pamler, W., Risch, L.

“…N and p channel FinFETs with fin widths in the range of 15–30 nm and gate lengths down to 20 nm have been processed using e-beam-lithography and nano-etching…”
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