Search Results - "Lander, E S"

Positive Natural Selection in the Human Lineage by Sabeti, P.C, Schaffner, S.F, Fry, B, Lohmueller, J, Varilly, P, Shamovsky, O, Palma, A, Mikkelsen, T.S, Altshuler, D, Lander, E.S

“…Positive natural selection is the force that drives the increase in prevalence of advantageous traits, and it has played a central role in our development as a…”
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Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring by Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., Bloomfield, C. D., Lander, E. S.

“…Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or…”
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Distinct physiological states of Plasmodium falciparum in malaria-infected patients by Mesirov, J. P, Regev, A, Daily, J. P, Scanfeld, D, Pochet, N, Le Roch, K, Plouffe, D, Kamal, M, Sarr, O, Mboup, S, Ndir, O, Wypij, D, Levasseur, K, Thomas, E, Tamayo, P, Dong, C, Zhou, Y, Lander, E. S, Ndiaye, D, Wirth, D, Winzeler, E. A

“…Infection with the malaria parasite Plasmodium falciparum leads to widely different clinical conditions in children, ranging from mild flu-like symptoms to…”
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Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus by SKLAR, P, GABRIEL, S. B, CRADDOCK, N, DEPAULO, J. R, LANDER, E. S, MCINNIS, M. G, BENNETT, P, LIM, Y-M, TSAN, G, SCHAFFNER, S, KIROV, G, JONES, I, OWEN, M

“…Identification of the genetic bases for bipolar disorder remains a challenge for the understanding of this disease. Association between 76 candidate genes and…”
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SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes by Neafsey, D.E, Lawniczak, M.K.N, Park, D.J, Redmond, S.N, Coulibaly, M.B, Traoré, S.F, Sagnon, N, Costantini, C, Johnson, C, Wiegand, R.C, Collins, F.H, Lander, E.S, Wirth, D.F, Kafatos, F.C, Besansky, N.J, Christophides, G.K, Muskavitch, M.A.T

“…Mosquitoes in the Anopheles gambiae complex show rapid ecological and behavioral diversification, traits that promote malaria transmission and complicate…”
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Parametric and nonparametric linkage analysis : A unified multipoint approach by KRUGLYAK, L, DALY, M. J, REEVE-DALY, M. P, LANDER, E. S

“…In complex disease studies, it is crucial to perform multipoint linkage analysis with many markers and to use robust nonparametric methods that take account of…”
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Multiclass Cancer Diagnosis Using Tumor Gene Expression Signatures by Ramaswamy, Sridhar, Tamayo, Pablo, Rifkin, Ryan, Mukherjee, Sayan, Yeang, Chen-Hsiang, Angelo, Michael, Ladd, Christine, Reich, Michael, Latulippe, Eva, Mesirov, Jill P., Poggio, Tomaso, Gerald, William, Loda, Massimo, Lander, Eric S., Golub, Todd R.

“…The optimal treatment of patients with cancer depends on establishing accurate diagnoses by using a complex combination of clinical and histopathological data…”
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Genomic analysis of metastasis reveals an essential role for RhoC by Clark, Edwin A, Golub, Todd R, Lander, Eric S, Hynes, Richard O

“…The most damaging change during cancer progression is the switch from a locally growing tumour to a metastatic killer. This switch is believed to involve…”
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The Plasticity of Dendritic Cell Responses to Pathogens and Their Components by Huang, Qian, Liu, Dongyu, Majewski, Paul, Schulte, Leah C., Korn, Joshua M., Young, Richard A., Lander, Eric S., Hacohen, Nir

“…Dendritic cells are involved in the initiation of both innate and adaptive immunity. To systematically explore how dendritic cells modulate the immune system…”
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Remodeling of yeast genome expression in response to environmental changes by Causton, H C, Ren, B, Koh, S S, Harbison, C T, Kanin, E, Jennings, E G, Lee, T I, True, H L, Lander, E S, Young, R A

“…We used genome-wide expression analysis to explore how gene expression in Saccharomyces cerevisiae is remodeled in response to various changes in extracellular…”
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Complete multipoint sib-pair analysis of qualitative and quantitative traits by KRUGLYAK, L, LANDER, E. S

“…Sib-pair analysis is an increasingly important tool for genetic dissection of complex traits. Current methods for sib-pair analysis are primarily based on…”
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Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes by Fambrough, Douglas, McClure, Kimberly, Kazlauskas, Andrius, Lander, Eric S

“…We sought to explore the relationship between receptor tyrosine kinase (RTK) activated signaling pathways and the transcriptional induction of immediate early…”
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Mapping Mendelian Factors Underlying Quantitative Traits Using RFLP Linkage Maps by Lander, E. S, Botstein, D

“…The advent of complete genetic linkage maps consisting of codominant DNA markers [typically restriction fragment length polymorphisms (RFLPs)] has stimulated…”
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Characterization of single-nucleotide polymorphisms in coding regions of human genes by Lander, Eric S, Cargill, Michele, Altshuler, David, Ireland, James, Sklar, Pamela, Ardlie, Kristin, Patil, Nila, Lane, Charles R, Lim, Esther P, Kalyanaraman, Nilesh, Nemesh, James, Ziaugra, Liuda, Friedland, Lisa, Rolfe, Alex, Warrington, Janet, Lipshutz, Robert, Daley, George Q

“…A major goal in human genetics is to understand the role of common genetic variants in susceptibility to common diseases. This will require characterizing the…”
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A nonparametric approach for mapping quantitative trait loci by Kruglyak, L. (Whitehead Institute for Biomedical Research, Cambridge, MA.), Lander, E.S

“…Genetic mapping of quantitative trait loci (QTLs) is performed typically by using a parametric approach, based on the assumption that the phenotype follows a…”
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Analysing complex genetic traits with chromosome substitution strains by Nadeau, Joseph H, Singer, Jonathan B, Matin, Angabin, Lander, Eric S

“…Many valuable animal models of human disease are known and new models are continually being generated in existing inbred strains,. Some disease models are…”
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Effectors of a Developmental Mitogen-Activated Protein Kinase Cascade Revealed by Expression Signatures of Signaling Mutants by Madhani, H. D., Galitski, T., Lander, E. S., Fink, G. R.

“…Despite the importance of mitogen-activated protein kinase (MAPK) signaling in eukaryotic biology, the mechanisms by which signaling yields phenotypic changes…”
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Ploidy Regulation of Gene Expression by Galitski, Timothy, Saldanha, Alok J., Styles, Cora A., Lander, Eric S., Fink, Gerald R.

“…Microarray-based gene expression analysis identified genes showing ploidy-dependent expression in isogenic Saccharomyces cerevisiae strains that varied in…”
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Genetic Dissection of Complex Traits by Lander, Eric S., Schork, Nicholas J.

“…Medical genetics was revolutionized during the 1980s by the application of genetic mapping to locate the genes responsible for simple Mendelian diseases. Most…”
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A Genetic Map of the Mouse Suitable for Typing Intraspecific Crosses by Dietrich, W, Katz, H, Lincoln, S. E, Shin, H. S, Friedman, J, Dracopoli, N. L, Lander, E. S

“…We report the construction of a genetic linkage map of the mouse, consisting entirely of genetic markers that can be rapidly typed by polymerase chain reaction…”
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