Search Results - "Landázuri, Manuel O"

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5 by Elorza, Ainara, Soro-Arnáiz, Inés, Meléndez-Rodríguez, Florinda, Rodríguez-Vaello, Victoria, Marsboom, Glenn, de Cárcer, Guillermo, Acosta-Iborra, Bárbara, Albacete-Albacete, Lucas, Ordóñez, Angel, Serrano-Oviedo, Leticia, Giménez-Bachs, Jose Miguel, Vara-Vega, Alicia, Salinas, Antonio, Sánchez-Prieto, Ricardo, Martín del Río, Rafael, Sánchez-Madrid, Francisco, Malumbres, Marcos, Landázuri, Manuel O., Aragonés, Julián

“…The mammalian target of rapamycin (mTOR) pathway, which is essential for cell proliferation, is repressed in certain cell types in hypoxia. However,…”
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Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity by Tello, Daniel, Balsa, Eduardo, Acosta-Iborra, Bárbara, Fuertes-Yebra, Esther, Elorza, Ainara, Ordóñez, Ángel, Corral-Escariz, María, Soro, Inés, López-Bernardo, Elia, Perales-Clemente, Ester, Martínez-Ruiz, Antonio, Enríquez, José Antonio, Aragonés, Julián, Cadenas, Susana, Landázuri, Manuel O.

“…The fine regulation of mitochondrial function has proved to be an essential metabolic adaptation to fluctuations in oxygen availability. During hypoxia, cells…”
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Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease by Cadenas, Susana, Aragonés, Julián, Landázuri, Manuel O.

“…Under hypoxic conditions, mitochondria can represent a threat to the cell because of their capacity to generate toxic reactive oxygen species (ROS). However,…”
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Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival by Conde, Elisa, Alegre, Laura, Blanco-Sánchez, Ignacio, Sáenz-Morales, David, Aguado-Fraile, Elia, Ponte, Belén, Ramos, Edurne, Sáiz, Ana, Jiménez, Carlos, Ordoñez, Angel, López-Cabrera, Manuel, del Peso, Luis, de Landázuri, Manuel O, Liaño, Fernando, Selgas, Rafael, Sanchez-Tomero, Jose Antonio, García-Bermejo, María Laura

“…Acute tubular necrosis (ATN) caused by ischemia/reperfusion (I/R) during renal transplantation delays allograft function. Identification of factors that…”
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Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor by Acosta-Iborra, Bárbara, Elorza, Ainara, Olazabal, Isabel M, Martín-Cofreces, Noa B, Martin-Puig, Silvia, Miró, Marta, Calzada, María J, Aragonés, Julián, Sánchez-Madrid, Francisco, Landázuri, Manuel O

“…Low oxygen tension areas are found in inflamed or diseased tissues where hypoxic cells induce survival pathways by regulating the hypoxia-inducible…”
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Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression by Miró-Murillo, Marta, Elorza, Ainara, Soro-Arnáiz, Inés, Albacete-Albacete, Lucas, Ordoñez, Angel, Balsa, Eduardo, Vara-Vega, Alicia, Vázquez, Silvia, Fuertes, Esther, Fernández-Criado, Carmen, Landázuri, Manuel O, Aragonés, Julián

“…Von Hippel Lindau (Vhl) gene inactivation results in embryonic lethality. The consequences of its inactivation in adult mice, and of the ensuing activation of…”
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NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain by Balsa, Eduardo, Marco, Ricardo, Perales-Clemente, Ester, Szklarczyk, Radek, Calvo, Enrique, Landázuri, Manuel O., Enríquez, José Antonio

“…The oxidative phosphorylation system is one of the best-characterized metabolic pathways. In mammals, the protein components and X-ray structures are defined…”
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Analysis of HIF-prolyl hydroxylases binding to substrates by Landázuri, Manuel O., Vara-Vega, Alicia, Vitón, Mariano, Cuevas, Yolanda, del Peso, Luis

“…Hypoxia inducible transcription factors (HIF) are mainly regulated by a group of proline hydroxylases (EGLNs) that, in the presence of oxygen, target HIF for…”
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c-Jun and Hypoxia-Inducible Factor 1 Functionally Cooperate in Hypoxia-Induced Gene Transcription by Alfranca, Arántzazu, Gutiérrez, M. Dolores, Vara, Alicia, Aragonés, Julián, Vidal, Felipe, Landázuri, Manuel O.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress by Anedda, Andrea, López-Bernardo, Elia, Acosta-Iborra, Bárbara, Saadeh Suleiman, M., Landázuri, Manuel O., Cadenas, Susana

“…Uncoupling protein 3 (UCP3) is a member of the mitochondrial inner membrane carrier superfamily that modulates energy efficiency by catalyzing proton…”
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Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1 by Pescador, Nuria, Villar, Diego, Cifuentes, Daniel, Garcia-Rocha, Mar, Ortiz-Barahona, Amaya, Vazquez, Silvia, Ordoñez, Angel, Cuevas, Yolanda, Saez-Morales, David, Garcia-Bermejo, Maria Laura, Landazuri, Manuel O, Guinovart, Joan, del Peso, Luis

“…When oxygen becomes limiting, cells reduce mitochondrial respiration and increase ATP production through anaerobic fermentation of glucose. The Hypoxia…”
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Down-regulation of Hypoxia-inducible Factor-2 in PC12 Cells by Nerve Growth Factor Stimulation by Naranjo-Suárez, Salvador, Castellanos, María Carmen, Álvarez-Tejado, Miguel, Vara, Alicia, Landázuri, Manuel O., del Peso, Luis

“…Cellular responses to low oxygen tension are mediated, at least in part, by the activation of the hypoxia-inducible factors (HIFs). In the presence of oxygen,…”
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Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene by Pescador, Nuria, Cuevas, Yolanda, Naranjo, Salvador, Alcaide, Marisa, Villar, Diego, Landázuri, Manuel O, Del Peso, Luis

“…Low oxygen levels induce an adaptive response in cells through the activation of HIFs (hypoxia-inducible factors). These transcription factors are mainly…”
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Up-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: role of transcription factor Egr-1 by Vidal, Felipe, Aragonés, Julián, Alfranca, Arántzazu, de Landázuri, Manuel O.

“…Vascular endothelial growth factor (VEGF) is highly expressed in vascular remodeling processes and accelerates reendothelialization after mechanical…”
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Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains by Villar, Diego, Vara-Vega, Alicia, Landázuri, Manuel O, Del Peso, Luis

“…HIFs [hypoxia-inducible (transcription) factors] are essential for the induction of an adaptive gene expression programme under low oxygen partial pressure…”
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The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen by del Peso, Luis, Castellanos, María C., Temes, Elisa, Martín-Puig, Silvia, Cuevas, Yolanda, Olmos, Gemma, Landázuri, Manuel O.

“…Most of the genes induced by hypoxia are regulated by a family of transcription factors termed hypoxia-inducible factors (HIF). Under normoxic conditions, HIFα…”
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von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms by Calzada, Maria J, Esteban, Miguel A, Feijoo-Cuaresma, Monica, Castellanos, Maria C, Naranjo-Suárez, Salvador, Temes, Elisa, Méndez, Fernando, Yánez-Mo, Maria, Ohh, Michael, Landázuri, Manuel O

“…Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is responsible for the development of renal cell cancers (RCC), pheochromocytomas, and tumors…”
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Lack of Evidence for the Involvement of the Phosphoinositide 3-Kinase/Akt Pathway in the Activation of Hypoxia-inducible Factors by Low Oxygen Tension by Alvarez-Tejado, Miguel, Alfranca, Arántzazu, Aragonés, Julian, Vara, Alicia, Landázuri, Manuel O., del Peso, Luis

“…Hypoxia-inducible factors (HIF) belong to an evolutionary conserved family of transcription factors, the activity of which is tightly regulated by oxygen…”
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Inadequate Activation of the GTPase RhoA Contributes to the Lack of Fibronectin Matrix Assembly in von Hippel-Lindau Protein-defective Renal Cancer Cells by Feijóo-Cuaresma, Monica, Méndez, Fernando, Maqueda, Alfredo, Esteban, Miguel A., Naranjo-Suarez, Salvador, Castellanos, Maria C., del Cerro, Mercedes Hernández, Vazquez, Silvia N., García-Pardo, Angeles, Landázuri, Manuel O., Calzada, Maria J.

“…The von Hippel-Lindau (VHL) tumor suppressor gene regulates extracellular matrix deposition. In VHL negative renal cancer cells, VHL(-), the lack of…”
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Evidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension by Aragonés, Julián, Jones, David R., Martı́n, Silvia, Juan, Miguel Angel San, Alfranca, Arántzazu, Vidal, Felipe, Vara, Alicia, Mérida, Isabel, Landázuri, Manuel O.

“…Hypoxia-inducible factor 1 (HIF-1) induces a gene expression program essential for the cellular adaptation to lowered oxygen environments. The intracellular…”
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