Search Results - "Lanciego, Jose Luis"

Prime time for G-protein-coupled receptor heteromers as therapeutic targets for CNS disorders: the dopamine D₁-D₃ receptor heteromer by Ferré, Sergi, Lluis, Carmen, Lanciego, José Luis, Franco, Rafael

“…A number of G-protein-coupled receptors (GPCRs) are currently under consideration as potential therapeutic targets for drugs acting in the central nervous…”
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Alterations in Gene and Protein Expression of Cannabinoid CB2 and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims by García-Gutiérrez, María S., Navarrete, Francisco, Navarro, Gemma, Reyes-Resina, Irene, Franco, Rafael, Lanciego, Jose Luis, Giner, Salvador, Manzanares, Jorge

“…Recent studies point to the cannabinoid CB 2 receptors (CB 2 r) and the non-cannabinoid receptor GPR55 as potential key targets involved in the response to…”
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History and future challenges of the subthalamic nucleus as surgical target: Review article by Guridi, Jorge, Rodriguez‐Rojas, Rafael, Carmona‐Abellán, Mar, Parras, Olga, Becerra, Victoria, Lanciego, Jose Luis

“…ABSTRACT For many years the subthalamic nucleus had a poor reputation among neurosurgeons as a result of the acute movement disorders that develop after its…”
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Past, present and future of A2A adenosine receptor antagonists in the therapy of Parkinson's disease by Armentero, Marie Therese, Pinna, Annalisa, Ferré, Sergi, Lanciego, José Luis, Müller, Christa E., Franco, Rafael

“…Several selective antagonists for adenosine A 2A receptors (A 2A R) are currently under evaluation in clinical trials (phases I to III) to treat Parkinson’s…”
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Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia by Navarro, Gemma, Borroto-Escuela, Dasiel, Angelats, Edgar, Etayo, Íñigo, Reyes-Resina, Irene, Pulido-Salgado, Marta, Rodríguez-Pérez, Ana I., Canela, Enric I., Saura, Josep, Lanciego, José Luis, Labandeira-García, José Luis, Saura, Carlos A., Fuxe, Kjell, Franco, Rafael

“…•LPS plus interferon-γ upregulate CB2 receptors in microglia.•LPS plus interferon-γ upregulate CB1-CB2 receptor complexes in microglia.•ß amyloid and LPS plus…”
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Cx3cr1‐deficiency exacerbates alpha‐synuclein‐A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease by Castro‐Sánchez, Sara, García‐Yagüe, Ángel J., López‐Royo, Tresa, Casarejos, Maria, Lanciego, José Luis, Lastres‐Becker, Isabel

“…Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the degeneration of dopaminergic neurons of the substantia nigra…”
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Brain delivery of microencapsulated GDNF induces functional and structural recovery in parkinsonian monkeys by Garbayo, Elisa, Ansorena, Eduardo, Lana, Hugo, Carmona-Abellan, María del Mar, Marcilla, Irene, Lanciego, José Luis, Luquin, María Rosario, Blanco-Prieto, María José

“…Abstract Glial cell line-derived neurotrophic factor (GDNF) remains the most potent neurotrophic factor for dopamine neurons. Despite its potential as…”
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Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain by Callén, Lucía, Moreno, Estefanía, Barroso-Chinea, Pedro, Moreno-Delgado, David, Cortés, Antoni, Mallol, Josefa, Casadó, Vicent, Lanciego, José Luis, Franco, Rafael, Lluis, Carmen, Canela, Enric I., McCormick, Peter J.

“…Exploring the role of cannabinoid CB2 receptors in the brain, we present evidence of CB2 receptor molecular and functional interaction with cannabinoid CB1…”
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Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD by García-Barroso, Carolina, Ricobaraza, Ana, Pascual-Lucas, María, Unceta, Nora, Rico, Alberto J., Goicolea, Maria Aranzazu, Sallés, Joan, Lanciego, José Luis, Oyarzabal, Julen, Franco, Rafael, Cuadrado-Tejedor, Mar, García-Osta, Ana

“…Previous studies have demonstrated that cognitive function can be restored in mouse models of Alzheimer's disease (AD) following administration of sildenafil,…”
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The cellular prion protein does not affect tau seeding and spreading of sarkosyl-insoluble fractions from Alzheimer’s disease by Sala-Jarque, Julia, Gil, Vanessa, Andrés-Benito, Pol, Martínez-Soria, Inés, Picón-Pagès, Pol, Hernández, Félix, Ávila, Jesús, Lanciego, José Luis, Nuvolone, Mario, Aguzzi, Adriano, Gavín, Rosalina, Ferrer, Isidro, del Río, José Antonio

“…The cellular prion protein (PrP C ) plays many roles in the developing and adult brain. In addition, PrP C binds to several amyloids in oligomeric and…”
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Adeno-Associated Viral Vectors as Versatile Tools for Parkinson’s Research, Both for Disease Modeling Purposes and for Therapeutic Uses by Fajardo-Serrano, Ana, Rico, Alberto J., Roda, Elvira, Honrubia, Adriana, Arrieta, Sandra, Ariznabarreta, Goiaz, Chocarro, Julia, Lorenzo-Ramos, Elena, Pejenaute, Alvaro, Vázquez, Alfonso, Lanciego, José Luis

“…It is without any doubt that precision medicine therapeutic strategies targeting neurodegenerative disorders are currently witnessing the spectacular rise of…”
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Long-term neuroprotection and neurorestoration by glial cell-derived neurotrophic factor microspheres for the treatment of Parkinson's disease by Garbayo, Elisa, Ansorena, Eduardo, Lanciego, Jose Luis, Blanco-Prieto, María Jose, Aymerich, María S.

“…Background: Glial cell‐derived neurotrophic factor is a survival factor for dopaminergic neurons and a promising candidate for the treatment of Parkinson's…”
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Recent Insights into the Pathogenesis of Acute Porphyria Attacks and Increasing Hepatic PBGD as an Etiological Treatment by Jericó, Daniel, Córdoba, Karol M, Sampedro, Ana, Jiang, Lei, Joucla, Gilles, Cabanne, Charlotte, Lanciego, José Luis, Martini, Paolo G V, Berraondo, Pedro, Ávila, Matías A, Fontanellas, Antonio

“…Rare diseases, especially monogenic diseases, which usually affect a single target protein, have attracted growing interest in drug research by encouraging…”
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GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells by Zamarbide, Marta, Etayo-Labiano, Iñigo, Ricobaraza, Ana, Martínez-Pinilla, Eva, Aymerich, María S., Luis Lanciego, José, Pérez-Mediavilla, Alberto, Franco, Rafael

“…ABSTRACT GPR40, the free fatty acid receptor 1, is expressed strongly in the primate pancreas and brain. While the role of pancreatic GPR40 in glucose…”
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Adeno-Associated Viral Vectors as Versatile Tools for Neurological Disorders: Focus on Delivery Routes and Therapeutic Perspectives by Fajardo-Serrano, Ana, Rico, Alberto J, Roda, Elvira, Honrubia, Adriana, Arrieta, Sandra, Ariznabarreta, Goiaz, Chocarro, Julia, Lorenzo-Ramos, Elena, Pejenaute, Alvaro, Vázquez, Alfonso, Lanciego, José Luis

“…It is without doubt that the gene therapy field is currently in the spotlight for the development of new therapeutics targeting unmet medical needs. Thus,…”
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Interactions between Calmodulin, Adenosine A2A, and Dopamine D2 Receptors by Navarro, Gemma, Aymerich, Marisol S., Marcellino, Daniel, Cortés, Antoni, Casadó, Vicent, Mallol, Josefa, Canela, Enric I., Agnati, Luigi, Woods, Amina S., Fuxe, Kjell, Lluís, Carmen, Lanciego, Jose Luis, Ferré, Sergi, Franco, Rafael

“…The Ca2+-binding protein calmodulin (CaM) has been shown to bind directly to cytoplasmic domains of some G protein-coupled receptors, including the dopamine D2…”
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Adeno-associated virus liver transduction efficiency measured by in vivo [18F]FHBG positron emission tomography imaging in rodents and nonhuman primates by Pañeda, Astrid, Collantes, Maria, Beattie, Stuart G, Otano, Itzia, Snapper, Jolanda, Timmermans, Eric, Guembe, Laura, Petry, Harald, Lanciego, Jose Luis, Benito, Alberto, Prieto, Jesus, Rodriguez-Pena, Maria Sol, Peñuelas, Iván, Gonzalez-Aseguinolaza, Gloria

“…Recombinant adeno-associated virus 5 (rAAV5) represents a candidate vector with unique advantages for the treatment of hepatic disorders because of its narrow…”
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Two types of periglomerular cells in the olfactory bulb of the macaque monkey (Macaca fascicularis) by Liberia, Teresa, Blasco-Ibáñez, José Miguel, Nácher, Juan, Varea, Emilio, Lanciego, José Luis, Crespo, Carlos

“…The olfactory bulb (OB) of mammals is the brain region that receives the sensory information coming from the olfactory epithelium. The entrance of the…”
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Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson’s Disease by Martínez-Pinilla, Eva, Aguinaga, David, Navarro, Gemma, Rico, Alberto J., Oyarzábal, Julen, Sánchez-Arias, Juan A., Lanciego, José Luis, Franco, Rafael

“…Cannabinoid CB 1 receptors (CB 1 R) and the GPR55 receptor are expressed in striatum and are potential targets in the therapy of Parkinson’s disease (PD), one…”
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Boolean analysis shows a high proportion of dopamine D2 receptors interacting with adenosine A2A receptors in striatal medium spiny neurons of mouse and non-human primate models of Parkinson's disease by Rivas-Santisteban, Rafael, Rico, Alberto José, Muñoz, Ana, Rodríguez-Pérez, Ana I., Reyes-Resina, Irene, Navarro, Gemma, Labandeira-García, José Luis, Lanciego, José Luis, Franco, Rafael

“…The antagonistic effect of adenosine on dopaminergic transmission in the basal ganglia indirect motor control pathway is mediated by dopamine D2 (D2R) and…”
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