Search Results - "Lanceta, Lilibeth"

Differential gene expression analysis of palbociclib-resistant TNBC via RNA-seq by Lanceta, Lilibeth, Lypova, Nadiia, O’Neill, Conor, Li, Xiaohong, Rouchka, Eric, Chesney, Jason, Imbert-Fernandez, Yoannis

“…Purpose The management of triple-negative breast cancer (TNBC) remains a significant clinical challenge due to the lack of effective targeted therapies…”
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PFKFB3 Inhibition Impairs Erlotinib-Induced Autophagy in NSCLCs by Lypova, Nadiia, Dougherty, Susan M., Lanceta, Lilibeth, Chesney, Jason, Imbert-Fernandez, Yoannis

“…Tyrosine kinase inhibitors (TKIs) targeting the kinase domain of the epidermal growth factor receptor (EGFR), such as erlotinib, have dramatically improved…”
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Haem oxygenase-1 overexpression alters intracellular iron distribution by Lanceta, Lilibeth, Li, Chi, Choi, Augustine M, Eaton, John W

“…Induction or ectopic overexpression of HO-1 (haem oxygenase 1) protects against a wide variety of disorders. These protective effects have been variably…”
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How Heme Oxygenase-1 Prevents Heme-Induced Cell Death by Lanceta, Lilibeth, Mattingly, Jacob M, Li, Chi, Eaton, John W

“…Earlier observations indicate that free heme is selectively toxic to cells lacking heme oxygenase-1 (HO-1) but how this enzyme prevents heme toxicity remains…”
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Targeting Palbociclib-Resistant Estrogen Receptor-Positive Breast Cancer Cells via Oncolytic Virotherapy by Lypova, Nadiia, Lanceta, Lilibeth, Gibson, Alana, Vega, Stephanie, Garza-Morales, Rodolfo, McMasters, Kelly M, Chesney, Jason, Gomez-Gutierrez, Jorge G, Imbert-Fernandez, Yoannis

“…While clinical responses to palbociclib have been promising, metastatic breast cancer remains incurable due to the development of resistance. We generated…”
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Gene Transfer of Inducible Nitric Oxide Synthase Affords Cardioprotection by Upregulating Heme Oxygenase-1 Via a Nuclear Factor-κB-Dependent Pathway by QIANHONG LI, YIRU GUO, SHINMURA, Ken, ROKOSH, Gregg D, SHUYAN WANG, BOLLI, Roberto, QINGHUI OU, CHUANJUE CUI, WU, Wen-Jian, WEI TAN, XIAOPING ZHU, LANCETA, Lilibeth B, SANGANALMATH, Santosh K, DAWN, Buddhadeb

“…Background— Although inducible nitric oxide synthase (iNOS) is known to impart powerful protection against myocardial infarction, the mechanism for this…”
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Abstract 1052: 6-phosphofructo-2-kinase enhances cytotoxicity of the EGFR inhibitor erlotinib via regulation of cell cycle in non-small lung cancer cell lines by Lypova, Nadiia, Lanceta, Lilibeth, Chesney, Jason, Imbert-Fernandez, Yoannis

“…Lung tumor development and aggressiveness is largely driven by a multitude of oncogenes including the epidermal growth factor receptor (EGFR). Targeted EGFR…”
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Abstract 6001: 6-Phosphofructo-2-kinase inhibition to increase the efficacy of ER and CDK4/6 inhibitors against ER+ breast cancer by Lanceta, Lilibeth, Lypova, Nadiia, Chesney, Jasson, Imbert-Fernandez, Yoannis

“…Deregulation of the estrogen receptor (ER)-cyclin D1-CDK4/6 pathway is a hallmark of ER+ breast cancer that has prompted the development of CDK4/6 inhibitors…”
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Inhibition of glucose metabolism through treatment of BRAF mutated metastatic melanoma with vemurafenib by Warrier, Govind, Lanceta, Lilibeth, Imbert-Fernandez, Yoannis, Chesney, Jason Alan

“…Abstract only e21005 Background: Increased glucose metabolism is a hallmark of neoplastic cells that allows self-promotion of growth and survival. The enzyme…”
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Abstract 2305: Targeting 6-phosphofructo-2-kinase to increase the efficacy of ER and CDK4/6 inhibitors against breast cancer by Imbert-Fernandez, Yoannis, Lanceta, Lilibeth, Telang, Sucheta, Chesney, Jason

“…We demonstrated that estradiol stimulates the expression and activity of an enzyme, 6-phosphofructo-2-kinase (PFKFB3), that regulates glucose metabolism via…”
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Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor by Chesney, Jason, Clark, Jennifer, Lanceta, Lilibeth, Trent, John O, Telang, Sucheta

“…Human tumors exhibit increased glucose uptake and metabolism as a result of high demand for ATP and anabolic substrates and this metabolotype is a negative…”
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Estradiol Stimulates Glucose Metabolism via 6-Phosphofructo-2-kinase (PFKFB3) by Imbert-Fernandez, Yoannis, Clem, Brian F., O'Neal, Julie, Kerr, Daniel A., Spaulding, Robert, Lanceta, Lilibeth, Clem, Amy L., Telang, Sucheta, Chesney, Jason

“…Estradiol (E2) administered to estrogen receptor-positive (ER+) breast cancer patients stimulates glucose uptake by tumors. Importantly, this E2-induced…”
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Genomic Deletion of PFKFB3 Decreases In Vivo Tumorigenesis by Imbert-Fernandez, Yoannis, Chang, Simone M, Lanceta, Lilibeth, Sanders, Nicole M, Chesney, Jason, Clem, Brian F, Telang, Sucheta

“…Rapidly proliferative processes in mammalian tissues including tumorigenesis and embryogenesis rely on the glycolytic pathway for energy and biosynthetic…”
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Abstract 6202: 6-Phosphofructo-2-kinase in regulating DNA damage and repair in EGFR-driven lung cancer by Lypova, Nadiia, Lanceta, Lilibeth, Dougherty, Susan, Chesney, Jason, Imbert-Fernandez, Yoannis

“…Activating mutations of epidermal growth factor receptor (mutEGFR) are established drivers of lung tumor development, aggressiveness, and resistance to…”
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Abstract P1-13-18: EGFR signaling contributes to acquired resistance to CDK4/6 inhibitors in ER+ breast cancer cells in vitro and in vivo by Lypova, Nadiia, Lanceta, Lilibeth, Daugherty, Susan, Chesney, Jason, Imbert-Fernandez, Yoannis

“…Breast cancer driven by different hormone receptors, including estrogen receptor (ER+), is responsible for approximately 70-80% of cases among women. While…”
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Abstract 1772: EGFR signaling as a mechanism of resistance to CDK4/6 inhibitors in Palbociclib-resistant ER+ breast cancer cells by Lypova, Nadiia, Lanceta, Lilibeth, Dougherty, Susan M., Chesney, Jason A., Imbert-Fernandez, Yoannis

“…Breast cancer driven by estrogen receptor (ER) is responsible for approximately 60-70% of cases among women. Selective inhibition of cyclin-dependent kinases 4…”
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Transcriptomic Profiling Identifies Differentially Expressed Genes in Palbociclib-Resistant ER+ MCF7 Breast Cancer Cells by Lanceta, Lilibeth, O'Neill, Conor, Lypova, Nadiia, Li, Xiahong, Rouchka, Eric, Waigel, Sabine, Gomez-Gutierrez, Jorge G, Chesney, Jason, Imbert-Fernandez, Yoannis

“…Acquired resistance to cyclin-dependent kinases 4 and 6 (CDK4/6) inhibition in estrogen receptor-positive (ER+) breast cancer remains a significant clinical…”
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Abstract 1614: Inducible Nitric Oxide Synthase Upregulates Heme Oxygenase-1 (HO-1) in Myocardium by Enhancing Nrf2 Phosphorylation and Binding to the HO-1 Promoter by Li, Qianhong, Ou, Qinghui, Tan, Wei, Wu, Wen-Jian, Zhu, Xiaoping, Lanceta, Lilibeth B, Rokosh, Gregg D, Guo, Yiru, Bolli, Roberto

“…Abstract only Previous studies have shown that iNOS gene transfer leads to elevated expression of HO-1, which in turn protects against ischemic injury…”
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GENE TRANSFER OF INDUCIBLE NITRIC OXIDE SYNTHASE AFFORDS CARDIOPROTECTION BY UPREGULATING HEME OXYGENASE-1 VIA AN NF-κB-DEPENDENT PATHWAY by Li, Qianhong, Guo, Yiru, Ou, Qinghui, Cui, Chuanjue, Wu, Wen-Jian, Tan, Wei, Zhu, Xiaoping, Lanceta, Lilibeth B, Sanganalmath, Santosh K., Dawn, Buddhadeb, Shinmura, Ken, Rokosh, Gregg D., Wang, Shuyan, Bolli, Roberto

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Regulation of Transmembrane Mucin Release by 15(S)–Hete in Ocular Surface Epithelia by Jumblatt, James E., Lanceta, Lilibeth, Jumblatt, Marcia M.

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