Search Results - "Lancaster, Jessica N"

Chemokine-Mediated Choreography of Thymocyte Development and Selection by Lancaster, Jessica N., Li, Yu, Ehrlich, Lauren I.R.

“…As they differentiate, thymocytes encounter spatially restricted cues critical for differentiation and selection of a functional, self-tolerant T cell…”
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CCR4 promotes medullary entry and thymocyte-dendritic cell interactions required for central tolerance by Hu, Zicheng, Lancaster, Jessica N, Sasiponganan, Chayanit, Ehrlich, Lauren I R

“…Autoimmunity results from a breakdown in central or peripheral tolerance. To establish central tolerance, developing T cells must enter the thymic medulla,…”
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Age-Related Changes in Thymic Central Tolerance by Srinivasan, Jayashree, Lancaster, Jessica N, Singarapu, Nandini, Hale, Laura P, Ehrlich, Lauren I R, Richie, Ellen R

“…Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive…”
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EBI2 contributes to the induction of thymic central tolerance in mice by promoting rapid motility of medullary thymocytes by Ki, Sanghee, Thyagarajan, Hiran M., Hu, Zicheng, Lancaster, Jessica N., Ehrlich, Lauren I.R.

“…Maturing thymocytes enter the thymic medulla, where they encounter numerous self‐antigens presented by antigen presenting cells (APCs). Those thymocytes that…”
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CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction by Thyagarajan, Hiran M, Lancaster, Jessica N, Lira, Sergio A, Ehrlich, Lauren I R

“…Following positive selection, thymocytes migrate into the medulla where they encounter diverse self-antigens that induce central tolerance. Thymocytes…”
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Aging of lymphoid stromal architecture impacts immune responses by Lancaster, Jessica N

“…The secondary lymphoid organs (SLOs) undergo structural changes with age, which correlates with diminishing immune responses against infectious disease. A…”
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Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation by Triplett, Todd A., Cardenas, Kim T., Lancaster, Jessica N., Hu, Zicheng, Selden, Hilary J., Jasso, Guadalupe J., Balasubramanyam, Sadhana, Chan, Kathy, Li, LiQi, Chen, Xi, Marcogliese, Andrea N., Davé, Utpal P., Love, Paul E., Ehrlich, Lauren I. R.

“…Primary T-cell acute lymphoblastic leukemia (T-ALL) cells require stromal-derived signals to survive. Although many studies have identified cell-intrinsic…”
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Age-Associated Changes to Lymph Node Fibroblastic Reticular Cells by Kwok, Tina, Medovich, Shannon C., Silva-Junior, Ildefonso A., Brown, Elise M., Haug, Joel C., Barrios, Marliece R., Morris, Karina A., Lancaster, Jessica N.

“…The decreased proportion of antigen-inexperienced, naïve T cells is a hallmark of aging in both humans and mice, and contributes to reduced immune responses,…”
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The aged microenvironment impairs BCL6 and CD40L induction in CD4+ T follicular helper cell differentiation by Fisher, Jacob S., Adán‐Barrientos, Irene, Kumar, Naveen R., Lancaster, Jessica N.

“…Weakened germinal center responses by the aged immune system result in diminished immunity against pathogens and reduced efficacy of vaccines. Prolonged…”
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Central tolerance is impaired in the middle‐aged thymic environment by Lancaster, Jessica N., Keatinge‐Clay, Damaris E., Srinivasan, Jayashree, Li, Yu, Selden, Hilary J., Nam, Seohee, Richie, Ellen R., Ehrlich, Lauren I. R.

“…One of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters…”
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Analysis of Thymocyte Migration, Cellular Interactions, and Activation by Multiphoton Fluorescence Microscopy of Live Thymic Slices by Lancaster, Jessica N, Ehrlich, Lauren I R

“…Thymocytes migrate through discrete compartments within the thymus, engaging in cellular interactions essential for their differentiation into functional and…”
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3D‐Printed Polymeric Biomaterials for Health Applications by Zhu, Yuxiang, Guo, Shenghan, Ravichandran, Dharneedar, Ramanathan, Arunachalam, Sobczak, M. Taylor, Sacco, Alaina F., Patil, Dhanush, Thummalapalli, Sri Vaishnavi, Pulido, Tiffany V., Lancaster, Jessica N., Yi, Johnny, Cornella, Jeffrey L., Lott, David G., Chen, Xiangfan, Mei, Xuan, Zhang, Yu Shrike, Wang, Linbing, Wang, Xianqiao, Zhao, Yiping, Hassan, Mohammad K., Chambers, Lindsay B., Theobald, Taylor G., Yang, Sui, Liang, Liang, Song, Kenan

“…Abstract 3D printing, also known as additive manufacturing, holds immense potential for rapid prototyping and customized production of functional…”
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Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment by Singarapu, Nandini, Ma, Keyue, Reeh, Kaitlin A. G., Shen, Jianjun, Lancaster, Jessica N., Yi, Song, Xie, Huafeng, Orkin, Stuart H., Manley, Nancy R., Ehrlich, Lauren I. R., Jiang, Ning, Richie, Ellen R.

“…Thymic epithelial cells (TEC) are essential for thymocyte differentiation and repertoire selection. Despite their indispensable role in generating functional T…”
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Detecting T cell activation using a varying dimension Bayesian model by Hu, Zicheng, Lancaster, Jessica N, Ehrlich, Lauren I. R., Müller, Peter

“…The detection of T cell activation is critical in many immunological assays. However, detecting T cell activation in live tissues remains a challenge due to…”
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Age-associated changes to lymph node architecture shape T cell responses by Lancaster, Jessica N, Da Silva, Ildefonso Alves, Kwok, Tina, Fisher, Jacob S

“…Abstract Aging dramatically impacts T cells, contributing to diminished and delayed responses to infection. While the development and maintenance of…”
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Age-associated changes to lymph node fibroblastic reticular cells by Lancaster, Jessica N, Kwok, Tina, Medovich, Shannon, da Silva, Ildefonso Alves

“…Abstract The decreased proportion of antigen-inexperienced, naïve T cells is a hallmark of aging in both humans and mice, and contributes to reduced immune…”
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CCR4 and CCR7 differentially regulate thymocyte subset localization with distinct outcomes for central tolerance by Li, Yu, Lancaster, Jessica N, Nam, Seohee, Seo, Hyemin, Ehrlich, Lauren Ilyse Richie

“…Abstract Central tolerance is established as T cells mature in the thymus by the combined effects of clonally deleting autoreactive thymocytes or inducing…”
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Two-photon imaging reveals distinct contributions of Aire+ medullary thymic epithelial cells and dendritic cell subsets to central tolerance induction by Ehrlich, Lauren I., Lancaster, Jessica N., Thyagarajan, Hiran Maye

“…Abstract Following positive selection, thymocytes migrate into the medulla where they encounter diverse tissue-restricted antigens (TRAs) that induce central…”
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The aged thymus is impaired in supporting T cell central tolerance by Lancaster, Jessica N, Srinivasan, Jayashree, Selden, Hilary J., Nam, Seohee, Ehrlich, Lauren Ilyse Richie

“…Abstract During aging, the thymus undergoes involution, decreasing dramatically in size and mass, and becoming increasingly disorganized. Notably, thymic…”
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CCR4 and CCR7 make distinct contributions to the spatial distribution and negative selection of different thymocyte subsets by Li, Yu, Lancaster, Jessica N, Nam, Seo Hee, Seo, Hyemin, Selden, Hilary J., Ehrlich, Lauren Ilyse Richie

“…Abstract Central tolerance mechanisms, including clonal deletion and Treg selection, are required to remove autoreactive T cells generated during thymocyte…”
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