Search Results - "Lanas A"

A review of the gastrointestinal safety data—a gastroenterologist’s perspective by Lanas, Angel

“…Although NSAIDs have a well-established place for certain indications in the management of OA and RA, they are associated with significant gastrointestinal…”
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Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials by BAIGENT, Colin

“…Summary Background The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors (coxibs)…”
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Peptic Ulcer Bleeding Risk. The Role of Helicobacter Pylori Infection in NSAID/Low-Dose Aspirin Users by Sostres, C, Carrera-Lasfuentes, P, Benito, R, Roncales, P, Arruebo, M, Arroyo, M T, Bujanda, L, García-Rodríguez, L A, Lanas, A

“…Helicobacter pylori (H. pylori) infection and NSAID/low-dose aspirin (ASA) use are associated with peptic ulcer disease. The risk of peptic ulcer bleeding…”
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Reappraisal of the clinical pharmacology of low‐dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action by Patrignani, P., Tacconelli, S., Piazuelo, E., Di Francesco, L., Dovizio, M., Sostres, C., Marcantoni, E., Guillem‐Llobat, P., Del Boccio, P., Zucchelli, M., Patrono, C., Lanas, A.

“…Summary Background Even though the acetylation of platelet cyclooxygenase (COX)‐1 at serine‐529 is the direct mechanism of action of low‐dose aspirin, its…”
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Celecoxib: A Review of its Use for Symptomatic Relief in the Treatment of Osteoarthritis, Rheumatoid Arthritis and Ankylosing Spondylitis by McCormack, Paul L.

“…Celecoxib (Celebrex®) was the first cyclo-oxygenase (COX)-2 selective inhibitor (coxib) to be introduced into clinical practice. Coxibs were developed to…”
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Low‐Dose Aspirin Acetylates Cyclooxygenase‐1 in Human Colorectal Mucosa: Implications for the Chemoprevention of Colorectal Cancer by Patrignani, P, Sacco, A, Sostres, C, Bruno, A, Dovizio, M, Piazuelo, E, Di Francesco, L, Contursi, A, Zucchelli, M, Schiavone, S, Tacconelli, S, Patrono, C, Lanas, A

“…The mechanism of action of low‐dose aspirin in the prevention of colorectal cancer (CRC) remains largely hypothetical. We aimed to compare the effects of…”
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Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin by YEOMANS, N. D., LANAS, A. I., TALLEY, N. J., THOMSON, A. B. R., DANESHJOO, R., ERIKSSON, B., APPELMAN‐ESZCZUK, S., LÅNGSTRÖM, G., NAESDAL, J., SERRANO, P., SINGH, M., SKELLY, M. M., HAWKEY, C. J.

“…Summary Background : Aspirin is valuable for preventing vascular events, but information about ulcer frequency is necessary to inform risk‐benefit decisions in…”
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Assessment of gastrointestinal and cardiovascular risk in patients with osteoarthritis who require NSAIDs: the LOGICA study by Lanas, Angel, Tornero, Jesús, Zamorano, José Luis

“…Medical management of adults with osteoarthritis (OA) who require non-steroidal anti-inflammatory drugs (NSAIDs) must be decided after assessing prevalent…”
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Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations by Lanas, A, García-Rodríguez, L A, Arroyo, M T, Gomollón, F, Feu, F, González-Pérez, A, Zapata, E, Bástida, G, Rodrigo, L, Santolaria, S, Güell, M, de Argila, C M, Quintero, E, Borda, F, Piqué, J M

“…Background: The risks and benefits of coxibs, non-steroidal anti-inflammatory drugs (NSAIDs), and aspirin treatment are under intense debate. Objective: To…”
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False-positive fecal immunochemical test results in colorectal cancer screening and gastrointestinal drug use by Domper Arnal, M. J., García Mateo, S., Hermoso-Durán, S., Abad, D., Carrera-Lasfuentes, P., Velazquez-Campoy, A., Abian Franco, O., Lanas, A.

“…Purpose The study aimed to determine the influence of drug treatments (proton pump inhibitors [PPIs] combined with other drugs) on the false-positive (FP) rate…”
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The aspirin cardiovascular/gastrointestinal risk calculator ‐ a tool to aid clinicians in practice by Lanas, A., Polo‐Tomás, M., Casado‐Arroyo, R.

“…Summary Background Assessment of both GI and CV risks vs. the benefits of low‐dose aspirin for individual patients can be difficult in clinical practice. Aim…”
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Effect of oral anticoagulants on the outcome of faecal immunochemical test by Bujanda, L, Sarasqueta, C, Lanas, Á, Quintero, E, Cubiella, J, Hernandez, V, Morillas, J D, Perez-Fernández, T, Salas, D, Andreu, M, Carballo, F, Bessa, X, Portillo, I, Jover, R, Balaguer, F, Cosme, A, Castells, A

“…Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC)…”
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The changing face of hospitalisation due to gastrointestinal bleeding and perforation by Lanas, A., García‐Rodríguez, L. A., Polo‐Tomás, M., Ponce, M., Quintero, E., Perez‐Aisa, M. A., Gisbert, J. P., Bujanda, L., Castro, M., Muñoz, M., Del‐Pino, M. D., Garcia, S., Calvet, X.

“…Aliment Pharmacol Ther 2011; 33: 585–591 Summary Background  Temporal changes in the incidence of cause‐specific gastrointestinal (GI) complications may be one…”
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Economic analysis of strategies in the prevention of non‐steroidal anti‐inflammatory drug‐induced complications in the gastrointestinal tract by Lanas, A.

“…Summary Background : It is unclear what the best therapeutic approach is in patients who require non‐steroidal anti‐inflammatory drugs. In clinical practice,…”
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Correction to: False-positive fecal immunochemical test results in colorectal cancer screening and gastrointestinal drug use by Arnal, M. J. Domper, Mateo, S. García, Hermoso-Durán, S., Abad, D., Carrera-Lasfuentes, P., Velazquez-Campoy, A., Abian Franco, O., Lanas, A.

“…A correction to this paper has been published: https://doi.org/10.1007/s00384-021-03947-1…”
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A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use by LANAS, Angel, PEREZ-AISA, Maria Angeles, NAVARRO, Jose M, CARBALLO, Fernando, CASTRO, Manuel, QUINTERO, Enrique, FEU, Faust, PONCE, Julio, SAPERAS, Esteban, SANTOLARIA, Santos, RODRIGO, Luis, BALANZO, Joaquim, BAJADOR, Eduardo, ALMELA, Pedro

“…The worst outcome of gastrointestinal complications is death. Data regarding those associated with nonsteroidal antiinflammatory drug (NSAID) or aspirin use…”
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Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low‐dose aspirin by Lanas, A., Fuentes, J., Benito, R., Serrano, P., Bajador, E., Sáinz, R.

“…Aim: To evaluate the role of Helicobacter pylori infection and other clinical factors in the risk of upper gastrointestinal bleeding in patients taking…”
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Clinical predictors of poor outcomes among patients with nonvariceal upper gastrointestinal bleeding in Europe by Lanas, A., Aabakken, L., Fonseca, J., Mungan, Z. A., Papatheodoridis, G. V., Piessevaux, H., Cipolletta, L., Nuevo, J., Tafalla, M.

“…Aliment Pharmacol Ther 2011; 33: 1225–1233 Summary Background  Nonvariceal upper gastrointestinal bleeding (NVUGIB) is a common medical emergency associated…”
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Risk factors associated with a decrease ≥2 g/dL in haemoglobin and/or ≥10% haematocrit in osteoarthritis patients taking celecoxib or a nonselective NSAID plus a PPI in a large randomised controlled trial (CONDOR) by Lanas, A., Goldstein, J. L., Chan, F. K. L., Wilcox, C. M., Peura, D. A., Li, C., Sands, G. H., Scheiman, J. M.

“…Summary Background Nonsteroidal anti‐inflammatory drugs are associated with gastrointestinal (GI) damage. The Celecoxib vs. Omeprazole and Diclofenac for…”
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Predictors of gastroduodenal erosions in patients taking low‐dose aspirin by HART, J., HAWKEY, C. J., LANAS, A., NAESDAL, J., TALLEY, N. J., THOMSON, A. B. R., YEOMANS, N. D.

“…Summary Background  Gastroduodenal ulcers are common in patients taking low‐dose aspirin. However, the factors predisposing to mucosal erosions, the precursor…”
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