Search Results - "Lanao, J M"

Drug tissue distribution: study methods and therapeutic implications by Lanao, J M, Fraile, M A

“…Current interest in studies on tissue distribution stems from the limited capacity to predict tissue concentrations and the pharmacological response from…”
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Population pharmacokinetics of amikacin in patients with haematological malignancies by ROMANO, S, FDEZ DE GATTA, M. M, CALVO, M. V, CABALLERO, D, DOMINGUEZ-GIL, A, LANAO, J. M

“…The aim of this study was to analyse the pharmacokinetic behaviour of amikacin in patients with haematological malignancies using a mixed-effect model and…”
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Time-dependent pharmacokinetics of cyclosporine (Neoral®) in de novo renal transplant patients by Lukas, J. C., Suárez, A. M., Valverde, M. P., Calvo, M. V., Lanao, J. M., Calvo, R., Suarez, E., Gil, A. D.

“…Summary Purpose:  A model for the large scale temporal trend in the oral bioavailability of microemulsion cyclosporine (Neoral®) (CsA) is established, with…”
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Population pharmacokinetics of high dose ibuprofen in cystic fibrosis by Arranz, I, Martín-Suárez, A, Lanao, J M, Mora, F, Vázquez, C, Escribano, A, Juste, M, Mercader, J, Ripoll, E

“…Aims: To evaluate ibuprofen population pharmacokinetics in a large series of data collected in children with cystic fibrosis (CF) treated with high doses of…”
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High-performance liquid chromatographic validated assay of doxorubicin in rat plasma and tissues by Álvarez-Cedrón, Loreto, Sayalero, M a Luisa, Lanao, José M.

“…A specific and selective high-performance liquid chromatography (HPLC) technique that requires few manipulations, and is readily adaptable to analysis for a…”
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Population pharmacokinetics of Digoxin in pediatric patients by MARTIN-SUAREZ, A, FALCAO, A. C, OUTEDA, M, HERNANDEZ, F. J, GONZALEZ, M. C, QUERO, M, ARRANZ, I, LANAO, J. M

“…Digoxin pharmacokinetics were studied in a pediatric population with an age range of 6 days to 1 year using the population pharmacokinetic approach. Digoxin…”
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Population pharmacokinetics of caffeine in premature neonates by FALCAO, A. C, DE GATTA, M. M. F, IRIBARNEGARAY, M. F. D, SANTOS BUELGA, D, GARCIA, M. J, DOMINGUEZ-GIL, A, LANAO, J. M

“…To determine population pharmacokinetic parameters of caffeine in premature neonates. This population analysis was done using 145 serum concentration…”
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Therapeutic Monitoring of Warfarin: the Appropriate Response Marker by COSTA, I. M., SOARES, P. J., AFONSO, M., RATADO, P., LANAO, J. M., FALCÃO, A. C.

“…Warfarin is a 4‐hydroxycoumarin anticoagulant drug used for the prevention and management of thromboembolic and vascular diseases. It acts through the…”
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Drug, enzyme and peptide delivery using erythrocytes as carriers by Millán, Carmen Gutiérrez, Marinero, Marı́a Luisa Sayalero, Castañeda, Aránzazu Zarzuelo, Lanao, José M

“…Erythrocytes are potential biocompatible vectors for different bioactive substances, including drugs. These can be used successfully as biological carriers of…”
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Neuropharmacokinetic characterization of lamotrigine after its acute administration to rats by CASTEL-BRANCO, M. M, FALCAO, A. C, FIGUEIREDO, I. V, CARAMONA, M. M, LANAO, J. M

“…The purpose of this study is to characterize the neuropharmacokinetics of lamotrigine following a single intraperitoneal dose. Adult male Wistar rats were…”
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Population pharmacokinetics of albendazole in patients with neurocysticercosis by Castro, N, Márquez-Caraveo, C, Brundage, R C, González-Esquivel, D, Suárez, A M, Góngora, F, Jara, A, Urizar, J, Lanao, J M, Jung, H

“…To determine a population pharmacokinetic model of the antihelmintic drug, albendazole, and identify the factors influencing the pharmacokinetic parameters in…”
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Determination of netilmicin in plasma by HPLC by Santos, M., Garcia, E., López, F.G., Lanao, J.M., Dominguez-Gil, A.

“…The aim of this work was to develop a high-performance liquid chromatography (HPLC) technique to determine netilmicin in plasma with pre-column derivatization…”
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A comparative study of ofloxacin and ciprofloxacin erythrocyte distribution by Colino, C. I., García Turiño, A., Sanchez Navarro, A., Lanao, J. M.

“…The present work deals with the in vitro and in vivo distribution of ofloxacin and ciprofloxacin in erythrocytes. In vitro studies were carried out in standard…”
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Distribution of ciprofloxacin in the isolated rat lung in the presence and absence of tissue oedema by Reinoso, Raquel F, Sánchez-Navarro, Amparo, Lanao, José M

“…A series of experiments with the isolated perfused rat lung was carried out to study the distribution of ciprofloxacin in this tissue under different…”
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Bayesian forecasting in paediatric populations by DEL MAR FERNANDEZ DE GATTA, M, GARCIA, M. J, LANAO, J. M, DOMINGUEZ-GIL, A

“…Bayesian forecasting offers several important advantages for dosage individualisation in children, although, unlike for adults, its use in this population is…”
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Influence of diagnostic and treatment factors in the population pharmacokinetics of gentamicin by ROMANO, S, GONZALEZ, P, TEJADA, P, ANTON, J, AGUADO, J. M, LANAO, J. M

“…Using the NONMEM program, the population kinetics of gentamicin were retrospectively studied in a series of 51 patients with different pathologies undergoing…”
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Pharmacokinetics of amikacin in intensive care unit patients by Fernández de Gatta, M M, Mendez, M E, Romano, S, Calvo, M V, Dominguez-Gil, A, Lanao, J M

“…To characterize the population pharmacokinetics of amikacin in intensive care unit (ICU) patients and to analyse whether these patients show different kinetic…”
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Population pharmacokinetics of gentamicin in premature infants by Izquierdo, M, Lanao, J M, Cervero, L, Jimenez, N V, Domínguez-Gil, A

“…The population kinetics of gentamicin were studied in 97 newborn patients with a gestational age ranging between 28 and 43 weeks and a postnatal age ranging…”
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A review of the isolated kidney as an experimental model for pharmacokinetic studies by ZARZUELO, A, SANCHEZ-NAVARRO, A, LOPEZ, F. G, LANAO, J. M

“…Traditional distribution studies have been based on methods affording steady-state partition coefficient or sparsely defined tissue profiles. Isolation organ…”
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Influence of pharmacokinetic model on vancomycin peak concentration targets by FERNANDEZ DE GATTA, M. M, FRUNS, I, CALVO, M. V, LANAO, J. M, DOMINGUEZ-GIL, A

“…The aim of this study was to adapt the vancomycin therapeutic range to the kinetic models usually employed in clinical settings (one- and two-compartment…”
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