Search Results - "Lanagan, Catherine"
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miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma
Published in Oncotarget (10-07-2015)“…To identify 'melanoma-specific' microRNAs (miRNAs) we used an unbiased microRNA profiling approach to comprehensively study cutaneous melanoma in relation to…”
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Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing
Published in Nature genetics (01-02-2012)“…Nicholas Hayward and colleagues sequenced eight metastatic melanoma exomes and identified frequent somatic mutations in two MAP kinase family genes, MAP3K5 and…”
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The ATM Ser49Cys Variant Effects ATM Function as a Regulator of Oncogene-Induced Senescence
Published in International journal of molecular sciences (01-02-2024)“…An apical component of the cell cycle checkpoint and DNA damage repair response is the ataxia-telangiectasia mutated (ATM) Ser/Thr protein kinase. A variant of…”
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Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo
Published in Clinical cancer research (15-06-2018)“…Checkpoint kinase 1 inhibitors (CHEK1i) have single-agent activity and Here, we have investigated the molecular basis of this activity. We have assessed a…”
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Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine
Published in Molecular oncology (01-07-2019)“…Drugs such as gemcitabine that increase replication stress are effective chemotherapeutics in a range of cancer settings. These drugs effectively block…”
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High efficiency ex vivo cloning of antigen-specific human effector T cells
Published in PloS one (04-11-2014)“…While cloned T cells are valuable tools for the exploration of immune responses against viruses and tumours, current cloning methods do not allow inferences to…”
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7
Dendritic cell immunotherapy for stage IV melanoma
Published in Melanoma research (01-10-2007)“…Active boosting of the antitumour immune response of patients with solid malignancies has been tested in a large number of trials. Isolated complete clinical…”
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Immunological characteristics correlating with clinical response to immunotherapy in patients with advanced metastatic melanoma
Published in Immunology and cell biology (01-06-2006)“…Current treatment options for advanced metastatic melanoma are limited to experimental regimen that provide poor survival outcomes. Immunotherapy is a…”
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Melanoma mutations modify melanocyte dynamics in co-culture with keratinocytes or fibroblasts
Published in Journal of cell science (15-12-2019)“…Melanocytic cell interactions are integral to skin homeostasis, and affect the outcome of multiple diseases, including cutaneous pigmentation disorders and…”
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Abstract A33: Defect in S phase cell cycle checkpoint renders tumours vulnerable to CHK1 inhibitor single-agent treatment in vitro and in vivo
Published in Molecular cancer research (01-04-2017)“…Abstract CHK1 inhibitors are being investigated as chemosensitizing agents with agents that increase replication stress. Here we have investigated the…”
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Durable complete clinical responses in a phase I/II trial using an autologous melanoma cell/dendritic cell vaccine
Published in Cancer Immunology, Immunotherapy (01-06-2003)“…Advanced metastatic melanoma is incurable by standard treatments, but occasionally responds to immunotherapy. Recent trials using dendritic cells (DC) as a…”
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Frequent somatic MAP3K5 and MAP3K9 mutations in metastatic melanoma identified by exome sequencing
Published in Nature genetics (25-12-2011)“…We sequenced 8 melanoma exomes to identify novel somatic mutations in metastatic melanoma. Focusing on the MAP3K family, we found that 24% of melanoma cell…”
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High Efficiency Ex Vivo Cloning of Antigen-Specific Human Effector T Cells: e110741
Published in PloS one (01-11-2014)“…While cloned T cells are valuable tools for the exploration of immune responses against viruses and tumours, current cloning methods do not allow inferences to…”
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