Search Results - "Lana, Susan"
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Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds
Published in PLoS genetics (13-05-2021)“…Histiocytic sarcoma is an aggressive hematopoietic malignancy of mature tissue histiocytes with a poorly understood etiology in humans. A histologically and…”
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Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in TP53, KMT genes and PDGFB fusions
Published in Scientific reports (27-06-2023)“…Soft tissue sarcomas (STS) are a heterogenous group of mesenchymal tumors representing over 50 distinct types with overlapping histological features and…”
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Author Correction: Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in TP53, KMT genes and PDGFB fusions
Published in Scientific reports (07-10-2024)Get full text
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Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression
Published in BMC genomics (23-12-2009)“…Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has…”
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Molecular landscape of canine soft tissue sarcoma
Published in The FASEB journal (01-05-2022)“…Canine soft tissue sarcomas (STS) are a heterogenous group of malignant tumors arising from mesenchymal cells of soft tissues. This simplified collective of…”
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Pathology in Practice
Published in Journal of the American Veterinary Medical Association (15-12-2021)“…In collaboration with the American College of Veterinary Pathologists…”
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Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs
Published in Clinical cancer research (01-06-2021)“…The mTOR pathway has been identified as a key nutrient signaling hub that participates in metastatic progression of high-grade osteosarcoma. Inhibition of mTOR…”
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Colorado State University, Pet Hospice Program
Published in The Veterinary clinics of North America. Small animal practice (01-05-2019)“…Serving clients since 2004, Colorado State University's Veterinary Teaching Hospital is the first and only program to offer a student-run pet hospice program…”
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Proliferative and Invasive Colorectal Tumors in Pet Dogs Provide Unique Insights into Human Colorectal Cancer
Published in Cancers (14-09-2018)“…Spontaneous tumors in pet dogs represent a valuable but undercharacterized cancer model. To better use this resource, we performed an initial global comparison…”
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Canine salivary gland carcinoma treated with stereotactic body radiation therapy: a retrospective case series
Published in Frontiers in veterinary science (27-06-2023)“…The aim of this study was to describe the therapeutic outcomes of dogs with locally advanced salivary gland carcinomas (SGC) following stereotactic body…”
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Outcome of stereotactic body radiation for treatment of nasal and nasopharyngeal lymphoma in 32 cats
Published in Journal of veterinary internal medicine (01-03-2022)“…Background The safety and efficacy of stereotactic body radiation therapy (SBRT) in the treatment of localized nasal lymphoma in cats has not been described…”
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Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma
Published in PloS one (19-06-2015)“…Interleukin (IL)-12 is a pro-inflammatory cytokine that mediates T-helper type 1 responses and cytotoxic T-cell activation, contributing to its utility as…”
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Immune pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma
Published in Communications biology (11-10-2021)“…Osteosarcoma affects about 2.8% of dogs with cancer, with a one-year survival rate of approximately 45%. The purpose of this study was to characterize mutation…”
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Characterizing the molecular and immune landscape of canine bladder cancer
Published in Veterinary & comparative oncology (01-03-2022)“…Transitional cell carcinoma (TCC), also known as urothelial carcinoma, is the most common bladder cancer in humans and dogs. Approximately one‐quarter of human…”
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Prospective evaluation of flow cytometric characteristics, histopathologic diagnosis and clinical outcome in dogs with naïve B‐cell lymphoma treated with a 19‐week CHOP protocol
Published in Veterinary & comparative oncology (01-09-2020)“…Canine B‐cell lymphoma is a clinically heterogenous disease; however, it is generally treated as a single disease entity. The purpose of this clinical trial…”
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Intensity of perioperative analgesia but not pre‐treatment pain is predictive of survival in dogs undergoing amputation plus chemotherapy for extremity osteosarcoma
Published in Veterinary & comparative oncology (01-09-2022)“…The purpose of this bi‐institutional retrospective study was to determine whether, in dogs treated with limb amputation and adjunctive chemotherapy for…”
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Pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide in cats after oral, intravenous, and intraperitoneal administration of cyclophosphamide
Published in American journal of veterinary research (01-07-2017)“…OBJECTIVE To characterize pharmacokinetics of cyclophosphamide and 4-hydoxycyclophosphamide (4-OHCP) in the plasma of healthy cats after oral, IV, and IP…”
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An aggressive CD4−CD8− T‐cell neoplasm in young English bulldogs
Published in Veterinary & comparative oncology (01-06-2022)“…T‐cell leukemia/lymphoma accounts for roughly 30% of all types of lymphoproliferative neoplasia in dogs. Two forms of T‐cell lymphoma (T‐zone and peripheral…”
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A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model
Published in PloS one (11-02-2016)“…Development of iniparib as an anti-cancer agent was hindered in part by lingering questions regarding its mechanism of action, the activity of its metabolites,…”
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Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials
Published in PloS one (17-03-2014)“…Molecularly-guided trials (i.e. PMed) now seek to aid clinical decision-making by matching cancer targets with therapeutic options. Progress has been hampered…”
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