Search Results - "Lamp, Scott T."

Burst pacemaker activity of the sinoatrial node in sodium–calcium exchanger knockout mice by Torrente, Angelo G., Zhang, Rui, Zaini, Audrey, Giani, Jorge F., Kang, Jeanney, Lamp, Scott T., Philipson, Kenneth D., Goldhaber, Joshua I.

“…In sinoatrial node (SAN) cells, electrogenic sodium–calcium exchange (NCX) is the dominant calcium (Ca) efflux mechanism. However, the role of NCX in the…”
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Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity by Groenke, Sabine, Larson, Eric D, Alber, Sarah, Zhang, Rui, Lamp, Scott T, Ren, Xiaoyan, Nakano, Haruko, Jordan, Maria C, Karagueuzian, Hrayr S, Roos, Kenneth P, Nakano, Atsushi, Proenza, Catherine, Philipson, Kenneth D, Goldhaber, Joshua I

“…The origin of sinoatrial node (SAN) pacemaker activity in the heart is controversial. The leading candidates are diastolic depolarization by "funny" current…”
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Intracellular Ca dynamics in ventricular fibrillation by Omichi, Chikaya, Lamp, Scott T, Lin, Shien-Fong, Yang, Junzhong, Baher, Ali, Zhou, Shengmei, Attin, Mina, Lee, Moon-Hyoung, Karagueuzian, Hrayr S, Kogan, Boris, Qu, Zhilin, Garfinkel, Alan, Chen, Peng-Sheng, Weiss, James N

“…In the heart, membrane voltage (Vm) and intracellular Ca (Cai) are bidirectionally coupled, so that ionic membrane currents regulate Cai cycling and Cai…”
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Intracellular calcium cycling, early afterdepolarizations, and reentry in simulated long QT syndrome by Huffaker, Ray, Lamp, Scott T, Weiss, James N, Kogan, Boris

“…The purpose of this study was to investigate interactions between early afterdepolarizations (EADs) and reentry in long QT (LQT) syndromes. EADs, a…”
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Atrioventricular ring reentry in embryonic mouse hearts by VALDERRABANO, Miguel, FUHUA CHEN, DAVE, Amish S, LAMP, Scott T, KLITZNER, Thomas S, WEISS, James N

“…During development, AV conduction switches from base-to-apex to apex-to-base conduction after emergence of the conduction system. We hypothesize that after…”
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Spatiotemporal Correlation Between Phase Singularities and Wavebreaks During Ventricular Fibrillation by LIU, YEN-BIN, PETER, ANISH, LAMP, SCOTT T., WEISS, JAMES N., CHEN, PENG-SHENG, LIN, SHIEN-FONG

“…Introduction: Phase maps and the detection of phase singularities (PSs) have become a well‐developed method for characterizing the organization of ventricular…”
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Coexistence of Two Types of Ventricular Fibrillation During Acute Regional Ischemia in Rabbit Ventricle by LIU, YEN-BIN, PAK, HUI-NAM, LAMP, SCOTT T., OKUYAMA, YUJI, HAYASHI, HIDEKI, WU, TSU-JUEY, WEISS, JAMES N., CHEN, PENG-SHENG, LIN, SHIEN-FONG

“…Introduction: We previously reported that a normal ventricle can demonstrate two types of ventricular fibrillation (VF), depending on the underlying…”
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Local regulation of the threshold for calcium sparks in rat ventricular myocytes: role of sodium-calcium exchange by Goldhaber, Joshua I., Lamp, Scott T., Walter, Donald O., Garfinkel, Alan, Fukumoto, Gary H., Weiss, James N.

“…To determine whether Na + -Ca 2+ exchange modulates Ca 2+ sparks, we studied enzymatically isolated patch clamped rat ventricular myocytes loaded with the Ca…”
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Glycolysis Preferentially Inhibits ATP-Sensitive K$^{+}$ Channels in Isolated Guinea Pig Cardiac Myocytes by Weiss, James N., Lamp, Scott T.

“…In heart, glycolysis may be a preferential source of adenosine triphosphate (ATP) for membrane functions. In this study the patch-clamp technique was used to…”
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Patterns of wave break during ventricular fibrillation in isolated swine right ventricle by Lee, M H, Qu, Z, Fishbein, G A, Lamp, S T, Chang, E H, Ohara, T, Voroshilovsky, O, Kil, J R, Hamzei, A R, Wang, N C, Lin, S F, Weiss, J N, Garfinkel, A, Karagueuzian, H S, Chen, P S

“…Several different patterns of wave break have been described by mapping of the tissue surface during fibrillation. However, it is not clear whether these…”
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Short-term cardiac memory and mother rotor fibrillation by Baher, Ali, Qu, Zhilin, Hayatdavoudi, Ashkan, Lamp, Scott T, Yang, Ming-Jim, Xie, Fagen, Turner, Stephen, Garfinkel, Alan, Weiss, James N

“…Short-term cardiac memory refers to the effects of pacing history on action potential duration (APD). Although the ionic mechanisms for short-term memory…”
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Anisotropic conduction block and reentry in neonatal rat ventricular myocyte monolayers by de Diego, Carlos, Chen, Fuhua, Xie, Yuanfang, Pai, Rakesh K, Slavin, Leonid, Parker, John, Lamp, Scott T, Qu, Zhilin, Weiss, James N, Valderrábano, Miguel

“…Anisotropy can lead to unidirectional conduction block that initiates reentry. We analyzed the mechanisms in patterned anisotropic neonatal rat ventricular…”
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Effect of Metabolic Inhibition on Couplon Behavior in Rabbit Ventricular Myocytes by Chantawansri, Chana, Huynh, Nhi, Yamanaka, Jun, Garfinkel, Alan, Lamp, Scott T., Inoue, Masashi, Bridge, John H.B., Goldhaber, Joshua I.

“…We investigated the effect of combined inhibition of oxidative and glycolytic metabolism on L-type Ca 2+ channels (LCCs) and Ca 2+ spikes in isolated…”
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Metabolic Inhibition Alters Subcellular Calcium Release Patterns in Rat Ventricular Myocytes: Implications for Defective Excitation-Contraction Coupling During Cardiac Ischemia and Failure by Fukumoto, Gary H, Lamp, Scott T, Motter, Christi, Bridge, John H.B, Garfinkel, Alan, Goldhaber, Joshua I

“…Metabolic inhibition (MI) contributes to contractile failure during cardiac ischemia and systolic heart failure, in part due to decreased…”
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Frequency Analysis of Ventricular Fibrillation in Swine Ventricles by Valderrábano, Miguel, Yang, Junzhong, Omichi, Chikaya, Kil, John, Lamp, Scott T, Qu, Zhilin, Lin, Shien-Fong, Karagueuzian, Hrayr S, Garfinkel, Alan, Chen, Peng-Sheng, Weiss, James N

“…It has been suggested from frequency analysis that cardiac fibrillation is driven by stable intramural reentry, with wavebreak occurring due to failure of 1:1…”
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Activation of ATP-Sensitive K+ Channels by Cromakalim: Effects on Cellular K+ Loss and Cardiac Function in Ischemic and Reperfused Mammalian Ventricle by Venkatesh, Nagammal, Stuart, Jeffrey S, Lamp, Scott T, Alexander, Laura D, Weiss, James N

“…Pharmacological modulation of [K]o accumulation and action potential changes during acute myocardial ischemia is under evaluation as a promising new…”
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Sulfonylureas, ATP-Sensitive K+ Channels, and Cellular K+ Loss During Hypoxia, Ischemia, and Metabolic Inhibition in Mammalian Ventricle by Venkatesh, Nagammal, Lamp, Scott T, Weiss, James N

“…Sulfonylurea derivatives glibenclamide and tolbutamide are selective blockers of ATP-sensitive K (KATP) channels. However, their ability to prevent cellular K…”
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Mechanism of hypoxic K loss in rabbit ventricle by Shivkumar, K, Deutsch, N A, Lamp, S T, Khuu, K, Goldhaber, J I, Weiss, J N

“…Although a critical factor causing lethal ischemic ventricular arrhythmias, net cellular K loss during myocardial ischemia and hypoxia is poorly understood. We…”
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