Search Results - "Lamp, S T"

Sulfonylureas, ATP-Sensitive K+ Channels, and Cellular K+ Loss During Hypoxia, Ischemia, and Metabolic Inhibition in Mammalian Ventricle by Venkatesh, Nagammal, Lamp, Scott T, Weiss, James N

“…Sulfonylurea derivatives glibenclamide and tolbutamide are selective blockers of ATP-sensitive K (KATP) channels. However, their ability to prevent cellular K…”
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ATP-sensitive K+ channels and cellular K+ loss in hypoxic and ischaemic mammalian ventricle by Weiss, J N, Venkatesh, N, Lamp, S T

“…1. The contribution of ATP-sensitive K+ (K+ATP) channels to the rapid increase in cellular K+ efflux and shortening of action potential duration (APD) during…”
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Cardiac ATP-sensitive K+ channels: evidence for preferential regulation by glycolysis by WEISS, J. N, LAMP, S. T

“…The ability of glycolysis, oxidative phosphorylation, the creatine kinase system, and exogenous ATP to suppress ATP-sensitive K+ channels and prevent cell…”
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Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle: implications for ischemia and reperfusion injury by GOLDHABER, J. I, SEN JI, LAMP, S. T, WEISS, J. N

“…Oxygen-derived free radicals have been implicated in the pathogenesis of cardiac dysfunction during ischemia, postischemic myocardial "stunning," and…”
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Activation of cardiac ATP-sensitive K+ current during hypoxia: correlation with tissue ATP levels by Deutsch, N, Klitzner, T S, Lamp, S T, Weiss, J N

“…Although previous work has implicated activation of ATP-sensitive K+ currents (IK,ATP) in action potential duration (APD) shortening and increased cellular K+…”
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Glycolysis Preferentially Inhibits ATP-Sensitive K$^{+}$ Channels in Isolated Guinea Pig Cardiac Myocytes by Weiss, James N., Lamp, Scott T.

“…In heart, glycolysis may be a preferential source of adenosine triphosphate (ATP) for membrane functions. In this study the patch-clamp technique was used to…”
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Cellular K+ loss and anion efflux during myocardial ischemia and metabolic inhibition by Weiss, J N, Lamp, S T, Shine, K I

“…It has been suggested that increased K+ efflux during myocardial hypoxia and ischemia may result from efflux of intracellularly generated anions such as…”
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Enhanced utilization of exogenous glucose improves cardiac function in hypoxic rabbit ventricle without increasing total glycolytic flux by RUNNMAN, E. M, LAMP, S. T, WEISS, J. N

“…The effects of elevated glucose on cardiac function during hypoxia were investigated in isolated arterially perfused rabbit interventricular septa. Rest…”
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Activation of ATP-Sensitive K+ Channels by Cromakalim: Effects on Cellular K+ Loss and Cardiac Function in Ischemic and Reperfused Mammalian Ventricle by Venkatesh, Nagammal, Stuart, Jeffrey S, Lamp, Scott T, Alexander, Laura D, Weiss, James N

“…Pharmacological modulation of [K]o accumulation and action potential changes during acute myocardial ischemia is under evaluation as a promising new…”
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Local regulation of the threshold for calcium sparks in rat ventricular myocytes: role of sodium-calcium exchange by Goldhaber, Joshua I., Lamp, Scott T., Walter, Donald O., Garfinkel, Alan, Fukumoto, Gary H., Weiss, James N.

“…To determine whether Na + -Ca 2+ exchange modulates Ca 2+ sparks, we studied enzymatically isolated patch clamped rat ventricular myocytes loaded with the Ca…”
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Mechanism of hypoxic K loss in rabbit ventricle by Shivkumar, K, Deutsch, N A, Lamp, S T, Khuu, K, Goldhaber, J I, Weiss, J N

“…Although a critical factor causing lethal ischemic ventricular arrhythmias, net cellular K loss during myocardial ischemia and hypoxia is poorly understood. We…”
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Patterns of wave break during ventricular fibrillation in isolated swine right ventricle by Lee, M H, Qu, Z, Fishbein, G A, Lamp, S T, Chang, E H, Ohara, T, Voroshilovsky, O, Kil, J R, Hamzei, A R, Wang, N C, Lin, S F, Weiss, J N, Garfinkel, A, Karagueuzian, H S, Chen, P S

“…Several different patterns of wave break have been described by mapping of the tissue surface during fibrillation. However, it is not clear whether these…”
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Intracellular Ca dynamics in ventricular fibrillation by Omichi, Chikaya, Lamp, Scott T, Lin, Shien-Fong, Yang, Junzhong, Baher, Ali, Zhou, Shengmei, Attin, Mina, Lee, Moon-Hyoung, Karagueuzian, Hrayr S, Kogan, Boris, Qu, Zhilin, Garfinkel, Alan, Chen, Peng-Sheng, Weiss, James N

“…In the heart, membrane voltage (Vm) and intracellular Ca (Cai) are bidirectionally coupled, so that ionic membrane currents regulate Cai cycling and Cai…”
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Intracellular calcium cycling, early afterdepolarizations, and reentry in simulated long QT syndrome by Huffaker, Ray, Lamp, Scott T, Weiss, James N, Kogan, Boris

“…The purpose of this study was to investigate interactions between early afterdepolarizations (EADs) and reentry in long QT (LQT) syndromes. EADs, a…”
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Metabolic Inhibition Alters Subcellular Calcium Release Patterns in Rat Ventricular Myocytes: Implications for Defective Excitation-Contraction Coupling During Cardiac Ischemia and Failure by Fukumoto, Gary H, Lamp, Scott T, Motter, Christi, Bridge, John H.B, Garfinkel, Alan, Goldhaber, Joshua I

“…Metabolic inhibition (MI) contributes to contractile failure during cardiac ischemia and systolic heart failure, in part due to decreased…”
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Frequency Analysis of Ventricular Fibrillation in Swine Ventricles by Valderrábano, Miguel, Yang, Junzhong, Omichi, Chikaya, Kil, John, Lamp, Scott T, Qu, Zhilin, Lin, Shien-Fong, Karagueuzian, Hrayr S, Garfinkel, Alan, Chen, Peng-Sheng, Weiss, James N

“…It has been suggested from frequency analysis that cardiac fibrillation is driven by stable intramural reentry, with wavebreak occurring due to failure of 1:1…”
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Spatiotemporal Correlation Between Phase Singularities and Wavebreaks During Ventricular Fibrillation by LIU, YEN-BIN, PETER, ANISH, LAMP, SCOTT T., WEISS, JAMES N., CHEN, PENG-SHENG, LIN, SHIEN-FONG

“…Introduction: Phase maps and the detection of phase singularities (PSs) have become a well‐developed method for characterizing the organization of ventricular…”
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Coexistence of Two Types of Ventricular Fibrillation During Acute Regional Ischemia in Rabbit Ventricle by LIU, YEN-BIN, PAK, HUI-NAM, LAMP, SCOTT T., OKUYAMA, YUJI, HAYASHI, HIDEKI, WU, TSU-JUEY, WEISS, JAMES N., CHEN, PENG-SHENG, LIN, SHIEN-FONG

“…Introduction: We previously reported that a normal ventricle can demonstrate two types of ventricular fibrillation (VF), depending on the underlying…”
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ATP-sensitive K super(+) channels and cellular K super(+) loss in hypoxic and ischaemic mammalian ventricle by Weiss, J N, Venkatesh, N, Lamp, ST

“…The contribution of ATP-sensitive K super(+) (K super(+) sub(A) sub(T) sub(P)) channels to the rapid increase in cellular K super(+) efflux and shortening of…”
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Sulfonylureas, ATP-sensitive K super(+) channels, and cellular K super(+) loss during hypoxia, ischemia, and metabolic inhibition in mammalian ventricle by Venkatesh, N, Lamp, ST, Weiss, J N

“…In the isolated arterially perfused rabbit interventricular septum, the increase in unidirectional K super(+) efflux and shortening of action potential…”
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