Search Results - "Lamothe, Tahirih L"

A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant by Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Panwar, Rajiv, Sarma, Ganapathy N, Kien, Lena, Dushime, Junia, Adams, Hillary L., Hyzy, Sharon L., Brooks, Melissa, Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, Lamothe, Tahirih L, Jain, Nidhi, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Current regimens for patient preparation, or conditioning, prior to bone marrow transplantation (BMT) limit the use of this curative procedure due to…”
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A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemic Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML) by Lanieri, Leanne, Lamothe, Tahirih L, Miske, Oliver, McDonough, Sean M, Sarma, Ganapathy N, Bhattarai, Prashant, Latimer, Kellie, Dushime, Junia, Jain, Nidhi, Palchaudhuri, Rahul, Knihtila, Ryan, Pearse, Bradley R, Proctor, Jennifer L, Boitano, Anthony E, Cooke, Michael P, Davis, John C.

“…Hematopoietic stem cell transplant (HSCT) can be a highly effective, and often curative, treatment for patients with AML. At present, myeloablative…”
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Single Agent CD117-Targeted Antibody Drug Conjugate in Combination with Lympho-Depleting Antibodies Enables Allogenic Hematopoietic Stem Cell Transplantation in Mice without Chemotherapy or Radiation by Lanieri, Leanne, Lamothe, Tahirih L., Bhattarai, Prashant raj, Palchaudhuri, Rahul, Olson, Lisa M

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300 - Single Agent CD117-Targeted Antibody Drug Conjugate in Combination with Lympho-Depleting Antibodies Enables Allogenic Hematopoietic Stem Cell Transplantation in Mice without Chemotherapy or Radiation by Lanieri, Leanne, Lamothe, Tahirih L., Bhattarai, Prashant raj, Palchaudhuri, Rahul, Olson, Lisa M

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Single Agent CD45-Targeted Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model by Hyzy, Sharon L., Proctor, Jennifer L, Gillard, Geoff O, Hammond, Katelyn J., Sarma, Ganapathy N., Saha, Asim, Clark, Nicholas, Bhat, Anjali, Lamothe, Tahirih L, Palchaudhuri, Rahul, Pearse, Bradley R, McDonagh, Charlotte F, Kiem, Hans-Peter, Wagner, John E, Blazar, Bruce R., Boitano, Anthony E, Cooke, Michael P, Davis, John C.

“…Introduction Allogeneic hematopoietic stem cell transplant (Allo-HSCT) is a potentially curative treatment for malignant and non-malignant blood disorders…”
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Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models by Palchaudhuri, Rahul, Hyzy, Sharon L., Proctor, Jennifer L, Adams, Hillary L, Pearse, Bradley R, Sarma, Ganapathy, Aslanian, Sharon, Gillard, Geoff, Lamothe, Tahirih L, Burenkova, Olga, Brooks, Melissa L., Gabros, Andrew D, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Introduction Targeted antibody drug conjugates (ADCs) to mouse CD45 or mouse CD117 have recently been shown to effectively prepare immunocompetent mice for…”
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A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT, Ameliorate Disease in Autoimmune Models, Potently Kill Human Immune Cells from Normal Donors and MS Patients, and Achieve Immune Depletion in Non-Human Primates (NHP) by Gillard, Geoff O, Proctor, Jennifer L, Brooks, Melissa L., Lamothe, Tahirih L, Hyzy, Sharon L., Mikse, Oliver, McDonough, Sean, Palchaudhuri, Rahul, Bhat, Anjali, Sarma, Ganapathy N., Bhattarai, Prashant, Sawant, Pranoti, Pearse, Bradley R, Mcdonough, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

“…Resetting the immune system through autologous hematopoietic stem cell transplant (autoHSCT) is a highly effective treatment in selected patients with…”
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Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning by Palchaudhuri, Rahul, Pearse, Bradley R, Proctor, Jennifer L, Hyzy, Sharon L., Aslanian, Sharon, McDonough, Sean M, Sarma, Ganapathy, Brooks, Melissa L., Bhat, Anjali, Ladwig, Danielle, McShea, Molly A, Kallen, Nathan M, Li, Qing, Panwar, Rajiv, Dushime, Junia, Sawant, Pranoti, Adams, Hillary L, Falahee, Patrick C., Lamothe, Tahirih L, Gabros, Andrew D, Kien, Lena, Gillard, Geoff, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Introduction Bone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders and has demonstrated impressive…”
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213 - A Single Dose of Anti-CD45 Antibody-Drug Conjugate Conditioning Enables Transplant in Nonhuman Primates by Palchaudhuri, Rahul, Demirci, Selami, Lanieri, Leanne, Hyzy, Sharon L., Bhat, Anjali, Lamothe, Tahirih L., Hammond, Katelyn, Tate, Tiffany, Guo, Zhuyan, Cheah, Eric, Qiao, Xin, Zeng, Jing, Maitland, Stacy A., Bennet, Bindu, Bertelsen, Kirk, Donahue, Robert E., Wolfe, Scot A., Bauer, Daniel E., Tisdale, John F., Olson, Lisa M.

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A Single Dose of Anti-CD45 Antibody-Drug Conjugate Conditioning Enables Transplant in Nonhuman Primates by Palchaudhuri, Rahul, Demirci, Selami, Lanieri, Leanne, Hyzy, Sharon L., Bhat, Anjali, Lamothe, Tahirih L., Hammond, Katelyn, Tate, Tiffany, Guo, Zhuyan, Cheah, Eric, Qiao, Xin, Zeng, Jing, Maitland, Stacy A., Bennet, Bindu, Bertelsen, Kirk, Donahue, Robert E., Wolfe, Scot A., Bauer, Daniel E., Tisdale, John F., Olson, Lisa M.

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A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemia Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML) by Lanieri, Leanne, Lamothe, Tahirih L., Mikse, Oliver, McDonough, Sean M., Sarma, Ganapathy N., Bhattarai, Prashant raj, Latimer, Kellie, Dushime, Junia, Jain, Nidhi, Knihtila, Ryan, Palchaudhuri, Rahul, Pearse, Bradley R., Boitano, Anthony E., Cooke, Michael P., Davis, John C, Olson, Lisa M, Proctor, Jennifer L.

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Targeted CD45 Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model As a Single Agent by Hyzy, Sharon L., Proctor, Jennifer L., Gillard, Geoffrey O., Hammond, Katelyn J., Sarma, Ganapathy N., Saha, Asim, Clark, Nicholas, Lamothe, Tahirih L., Palchaudhuri, Rahul, Pearse, Bradley R., McDonagh, Charlotte F., Kiem, Hans-Peter, Wagner, John E., Blazar, Bruce R., Boitano, Anthony E., Cooke, Michael P., Davis, John C

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A Non-Genotoxic Anti-CD117 Antibody Drug Conjugate (ADC) Designed for Patient Conditioning Prior to Stem Cell Transplant and HSC-Based Gene Therapy Has a Broad Therapeutic Window across Species by Pearse, Bradley R., Proctor, Jennifer L., McDonough, Sean M., Panwar, Rajiv, Sarma, Ganapathy N., Neale, Jason, Kien, Lena, Dushime, Junia, Latimer, Kellie, Lamothe, Tahirih L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Jain, Nidhi, Knihtila, Ryan, McDonagh, Charlotte F., Boitano, Anthony E., Davis, John C., Cooke, Michael P.

“…Current approaches to conditioning prior to transplant and gene therapy employ non-specific genotoxic agents that are associated with severe acute and…”
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A Single Dose of a Novel Anti-Human Short Half-Life Engineered CD45-Targeted Antibody-Drug Conjugate (ADC) Is Cytoreductive on Patient-Derived Tumors and Extends Survival Beyond Standards of Care in Multiple Pre-Clinical Models of Hematologic Malignancy by Proctor, Jennifer L., Gillard, Geoffrey O., Mikse, Oliver, Lanieri, Leanne, Lamothe, Tahirih L., Brooks, Melissa L., Kien, Lena, McDonough, Sean M., Bhat, Anjali, Palchaudhuri, Rahul, Bhattarai, Prashant raj, Sarma, Ganapathy N., Jain, Nidhi, McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

“…For patients with refractory or high-risk hematologic malignancies, like acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and acute lymphoblastic…”
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A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT and Ameliorate Disease in Preclinical Autoimmune Disease Models by Gillard, Geoffrey O., Proctor, Jennifer L., Brooks, Melissa L., Lamothe, Tahirih L., Hyzy, Sharon L., McDonough, Sean M., Clark, Nicholas, Palchaudhuri, Rahul, Bhat, Anjali, Sarma, Ganapathy N., Bhattarai, Prashant Raj, Sawant, Pranoti, Pearse, Bradley R., McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

“…Resetting the immune system through autologous hematopoietic stem cell transplant (autoHSCT) is a highly effective treatment in patients with autoimmune…”
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Successful Allogeneic Hematopoietic Stem Cell Transplantation in Mice Mediated By Well-Tolerated Conditioning Regimens Based on CD45-Targeted Antibody Drug Conjugate: Implications for Haplo Transplantation by Hyzy, Sharon L., Palchaudhuri, Rahul, Proctor, Jennifer L., Pearse, Bradley R., Sarma, Ganapathy N., Gillard, Geoff O., Saha, Asim, Lamothe, Tahirih L., Brooks, Melissa L., Hammond, Katelyn, Bhat, Anjali, Clark, Nicholas, McDonagh, Charlotte F., Kiem, Hans-Peter, Wagner, John E., Blazar, Bruce R., Boitano, Anthony E., Cooke, Michael P.

“…Allogeneic hematopoietic stem cell transplant (Allo-HSCT) is a potentially curative treatment for malignant and non-malignant blood disorders. However, current…”
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CD45-Targeted Antibody Drug Conjugate Plus Post Transplant Cytoxan Is Sufficient to Enable Allogeneic Bone Marrow Transplant in a Minor Mismatch Mouse Model by Hyzy, Sharon L., Palchaudhuri, Rahul, Proctor, Jennifer L., Pearse, Brad R., Sarma, Ganapathy N., Adams, Hillary L., Aslanian, Sharon, Gillard, Geoff O., Lamothe, Tahirih L., Burenkova, Olga, Brooks, Melissa, Gabros, Andrew D., McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

“…Bone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders. Current regimens for patient preparation, or…”
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Non-Genotoxic Conditioning Using Amanitin Antibody-Drug Conjugates Targeting CD45 Effectively Deplete Human and Non-Human Primate Hematopoietic Stem Cells and Immune Cells by Palchaudhuri, Rahul, Pearse, Brad R., Proctor, Jennifer L., Hyzy, Sharon L., Aslanian, Sharon, Bhat, Anjali, Gillard, Geoff O, McDonough, Sean M., Sarma, Ganapathy N, Ladwig, Danielle, Li, Qing, Jain, Nidhi, Panwar, Rajiv, Sawant, Pranoti, Dushime, Junia, Falahee, Patrick C., Kien, Lena, Lamothe, Tahirih L, Gabros, Andrew D, Adams, Hillary L., McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

“…Bone Marrow Transplant (BMT) is a potentially curative treatment for malignant and non-malignant blood disorders. Current regimens for patient preparation, or…”
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