Search Results - "Lamothe, Shawn M."

The Serum- and Glucocorticoid-inducible Kinases SGK1 and SGK3 Regulate hERG Channel Expression via Ubiquitin Ligase Nedd4-2 and GTPase Rab11 by Lamothe, Shawn M., Zhang, Shetuan

“…The hERG (human ether-a-go-go-related gene) encodes the α subunit of the rapidly activating delayed rectifier potassium channel (IKr). Dysfunction of hERG…”
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Glycosylation stabilizes hERG channels on the plasma membrane by decreasing proteolytic susceptibility by Lamothe, Shawn M., Hulbert, Maggie, Guo, Jun, Li, Wentao, Yang, Tonghua, Zhang, Shetuan

“…The human ether‐a‐go‐go related gene (hERG)–encoded channel hERG undergoes N‐linked glycosylation at position 598, which is located in the unusually long…”
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Reducing agents facilitate membrane patch seal integrity and longevity by Das, Damayantee, Wong, Anson, Friedman, Timothy N, Kerr, Bradley J, Kurata, Harley T, Lamothe, Shawn M

“…The patch clamp method is a widely applied electrophysiological technique used to understand ion channel activity and cellular excitation. The formation of a…”
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Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels by Lamothe, Shawn M, Sharmin, Nazlee, Silver, Grace, Satou, Motoyasu, Hao, Yubin, Tateno, Toru, Baronas, Victoria A, Kurata, Harley T

“…Many voltage-dependent ion channels are regulated by accessory proteins. We recently reported powerful regulation of Kv1.2 potassium channels by the amino acid…”
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Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2 by Wang, Tingzhong, Hogan-Cann, Andrew, Kang, Yudi, Cui, Zhi, Guo, Jun, Yang, Tonghua, Lamothe, Shawn M, Li, Wentao, Ma, Aiqun, Fisher, John T, Zhang, Shetuan

“…The human ether-à-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel, which is important…”
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Febrile temperature facilitates hERG/IKr degradation through an altered K+ dependence by Zhao, Yan, MSc, Wang, Tingzhong, PhD, Guo, Jun, BM, Yang, Tonghua, BM, Li, Wentao, BSc, Koichopolos, Jennifer, BSc, Lamothe, Shawn M., MSc, Kang, Yudi, MSc, Ma, Aiqun, MD, Zhang, Shetuan, PhD

“…Background Dysfunction of the rapidly activating delayed rectifier K+ channel (IKr ) encoded by the human ether-à-go-go-related gene ( hERG ) is the primary…”
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The Human Ether-a-go-go-related Gene (hERG) Potassium Channel Represents an Unusual Target for Protease-mediated Damage by Lamothe, Shawn M., Guo, Jun, Li, Wentao, Yang, Tonghua, Zhang, Shetuan

“…The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr), which is…”
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Competition between Slc7a5 and LMAN2 for modulation of Kv1.2 gating by Das, Damayantee, Lamothe, Shawn M., Baronas, Victoria A., Kurata, Harley T.

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Modulation of heteromeric Kv1 channels by transmembrane lectins and redox by Wong, Anson, Lamothe, Shawn M., Baronas, Victoria A., Kurata, Harley T.

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Slc7a5 alters Kvβ-mediated regulation of Kv1.2 by Lamothe, Shawn M, Kurata, Harley T

“…The voltage-gated potassium channel Kv1.2 plays a pivotal role in neuronal excitability and is regulated by a variety of known and unknown extrinsic factors…”
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Modulation of Kv1.2 redox-sensitive gating by the transmembrane lectin LMAN2 by Lamothe, Shawn M., Das, Damayantee, Wong, Anson, Hao, Yubin, Baronas, Victoria A., Kurata, Harley T.

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Heteromeric Assembly of Truncated Neuronal Kv7 Channels: Implications for Neurologic Disease and Pharmacotherapy by Li, Jingru, Maghera, Jasmine, Lamothe, Shawn M., Marco, Elysa J., Kurata, Harley T.

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Endoplasmic reticulum stress in the dorsal root ganglia regulates large‐conductance potassium channels and contributes to pain in a model of multiple sclerosis by Yousuf, Muhammad Saad, Samtleben, Samira, Lamothe, Shawn M., Friedman, Timothy N., Catuneanu, Ana, Thorburn, Kevin, Desai, Mansi, Tenorio, Gustavo, Schenk, Geert J., Ballanyi, Klaus, Kurata, Harley T., Simmen, Thomas, Kerr, Bradley J.

“…Neuropathic pain is a common symptom of multiple sclerosis (MS) and current treatment options are ineffective. In this study, we investigated whether…”
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A structure-based computational workflow to predict liability and binding modes of small molecules to hERG by Kalyaanamoorthy, Subha, Lamothe, Shawn M., Hou, Xiaoqing, Moon, Tae Chul, Kurata, Harley T., Houghton, Michael, Barakat, Khaled H.

“…Off-target interactions of drugs with the human ether-à-go-go related gene 1 (hERG1) channel have been associated with severe cardiotoxic conditions leading to…”
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Anti-Ro52 antibody acts on the S5-pore linker of hERG to chronically reduce channel expression by Szendrey, John, Lamothe, Shawn M, Vanner, Stephanie, Guo, Jun, Yang, Tonghua, Li, Wentao, Davis, Jordan, Joneja, Mala, Baranchuk, Adrian, Zhang, Shetuan

“…Abstract Aims The human ether-a-go-go-related gene (hERG) encodes the rapidly activating delayed rectifier potassium channel (IKr). Malfunction of hERG/IKr is…”
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The N terminus and transmembrane segment S1 of Kv1.5 can coassemble with the rest of the channel independently of the S1–S2 linkage by Lamothe, Shawn M., Hogan-Cann, Aja E., Li, Wentao, Guo, Jun, Yang, Tonghua, Tschirhart, Jared N., Zhang, Shetuan

“…The voltage-gated potassium channel Kv1.5 belongs to the Shaker superfamily. Kv1.5 is composed of four subunits, each comprising 613 amino acids, which make up…”
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Pore- and voltage sensor-targeted KCNQ openers have distinct state-dependent actions by Wang, Caroline K, Lamothe, Shawn M, Wang, Alice W, Yang, Runying Y, Kurata, Harley T

“…Ion channels encoded by generate a prominent K conductance in the central nervous system, referred to as the M current, which is controlled by membrane voltage…”
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Hypoxia reduces mature hERG channels through calpain up‐regulation by Lamothe, Shawn M., Song, WonJu, Guo, Jun, Li, Wentao, Yang, Tonghua, Baranchuk, Adrian, Graham, Charles H., Zhang, Shetuan

“…Human ether‐a‐go‐go‐related gene (hERG) encodes the pore‐forming subunit of the rapidly activating delayed rectifier potassium current (IKr) potassium channel,…”
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Differential Regulation of Human Ether-à-Go-Go-Related Gene (hERG) Current and Expression by Activation of Protein Kinase C by Sutherland-Deveen, Morgan E, Wang, Tingzhong, Lamothe, Shawn M, Tschirhart, Jared N, Guo, Jun, Li, Wentao, Yang, Tonghua, Du, Yuan, Zhang, Shetuan

“…The ( ) encodes the channel that conducts the rapidly activating delayed rectifier potassium current (I ) in the heart. Reduction in I causes long QT syndrome,…”
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Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel by Chen, Jeffery, Guo, Jun, Yang, Tonghua, Li, Wentao, Lamothe, Shawn M., Kang, Yudi, Szendrey, John A., Zhang, Shetuan

“…The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr). A reduction…”
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