Search Results - "Lamoreux, M. L"

Genetic Studies of the Mouse Mutations mahogany and mahoganoid by Miller, K. A, Gunn, T. M, Carrasquillo, M. M, Lamoreux, M. L, Galbraith, D. B, Barsh, G. S

“…The mouse mutations mahogany (mg) and mahoganoid (md) are negative modifiers of the Agouti coat color gene, which encodes a paracrine signaling molecule that…”
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Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo by Ollmann, M M, Lamoreux, M L, Wilson, B D, Barsh, G S

“…Agouti protein and Agouti-related protein (Agrp) are paracrine-signaling molecules that normally regulate pigmentation and body weight, respectively. These…”
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Molecular basis of mouse microphthalmia ( mi ) mutations helps explain their developmental and phenotypic consequences by Burley, Stephen K, Sanders Zimring, Debra C, Arnheiter, Heinz, Lamoreux, M. Lynn, Moore, Karen J, Copeland, Neal G, Steingrímsson, Eiríkur, Hodgkinson, Colin A, Ferré-D'Amaré, Adrian R, Skow, Loren C, Jenkins, Nancy A

“…Mutations in the mouse microphthalmia (mi) gene affect the development of a number of cell types including melanocytes, osteoclasts and mast cells. Recently,…”
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Agouti Signaling Protein Inhibits Melanogenesis and the Response of Human Melanocytes to α-Melanotropin by Suzuki, Itaru, Tada, Akihiro, Ollmann, Michael M., Barsh, Gregory S., Im, Sungbin, Lynn Lamoreux, M., Hearing, Vincent J., Nordlund, James J., Abdel-Malek, Zalfa A.

“…In mouse follicular melanocytes, the switch between eumelanin and pheomelanin synthesis is regulated by the extension locus, which encodes the melanocortin-1…”
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The vit gene maps to the mi (microphthalmia) locus of the laboratory mouse by Lamoreux, M L, Boissy, R E, Womack, J E, Nordlund, J J

“…The murine model for human vitiligo (the vit/vit mouse) develops progressive depigmentation of the pelage, skin, and eyes. The vit gene is inherited as an…”
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Misrouting of tyrosinase with a truncated cytoplasmic tail as a result of the murine platinum ( c p) mutation by Beermann, Friedrich, Orlow, Seth J., Boissy, Raymond E., Schmidt, Andrea, Boissy, Ying L., Lamoreux, M. Lynn

“…Mice homozygous for the platinum ( c p) allele at the albino locus manifest severe oculocutaneous albinism despite the presence in vitro of tyrosinase activity…”
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Microphthalmia Cloudy-Eye (mice): A New Murine Allele by Zimring, D. C., Lamoreux, M. L., Millichamp, N. J., Skow, L. C.

“…In 1989, a white, pink-eyed mouse was discovered in a production colony of DBA/2N mice supported by the National Cancer Institute (NCI). Genetic profiling by…”
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Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein by Costin, Gertrude-E, Valencia, Julio C, Wakamatsu, Kazumasa, Ito, Shosuke, Solano, Francisco, Milac, Adina L, Vieira, Wilfred D, Yamaguchi, Yuji, Rouzaud, François, Petrescu, Andrei-J, Lamoreux, M Lynn, Hearing, Vincent J

“…Dopachrome tautomerase (Dct) is a type I membrane protein and an important regulatory enzyme that plays a pivotal role in the biosynthesis of melanin and in…”
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Postnatal ocular expression of tyrosinase and related proteins: disruption by the pink-eyed unstable (p(un)) mutation by Chiu, E, Lamoreux, M L, Orlow, S J

“…Ocular pigmentation in the mouse occurs primarily postnatally as a result of the melanization of neural crest-derived melanocytes. Using immunologic and…”
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Mapping the bovine albino locus by Foreman, M E, Lamoreux, M L, Kwon, B, Womack, J E

“…The albino, beta-hemoglobin, and lactate dehydrogenase A (LDHA) loci comprise a highly conserved syntenic group in those mammals in which the three loci have…”
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A Mouse Model for Vitiligo by Lerner, Aaron B., Shiohara, Tetsuo, Boissy, Raymond E., Jacobson, Kirsten A., Lamoreux, M. Lynn, Moellmann, Gisela E.

“…As the result of a long search for a depigmenting mouse that could serve as a model for the study of vitiligo, we have located a strain that arose from the…”
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Pathogenesis of the Platinum (cP) Mutation, a Model for Oculocutaneous Albinism by Orlow, Seth J, Lamoreux, M Lynn, Pifko-Hirst, Sharon, Zhou, Bao-Kang

“…The platinum mutation at the C (albino) locus in the mouse is a potential model for oculocutaneous albinism in humans other than type IA (tyrosinase-negative)…”
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GENETIC CONTROLS OVER ACTIVITIES OF TYROSINASE AND DOPACHROME CONVERSION FACTOR IN MURINE MELANOCYTES by Lamoreux, M. Lynn, Woolley, Catherine, Pendergast, Phil

“…We evaluated the three catalytic activities of tyrosinase and one activity of dopachrome conversion factor (DCF) in extracts made from skins of 6-day-old…”
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Genomic, Transcriptional and Mutational Analysis of the Mouse microphthalmia Locus by Hallsson, Jon H, Favor, Jack, Hodgkinson, Colin, Glaser, Tom, Lamoreux, M. Lynn, Magnusdottir, Rannveig, Gunnarsson, Gunnar J, Sweet, Hope O, Copeland, Neal G, Jenkins, Nancy A, Steingrimsson, Eirikur

“…Mouse microphthalmia transcription factor (Mitf) mutations affect the development of four cell types: melanocytes, mast cells, osteoclasts, and pigmented…”
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The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes by Abdel-Malek, Z A, Scott, M C, Furumura, M, Lamoreux, M L, Ollmann, M, Barsh, G S, Hearing, V J

“…The agouti gene codes for agouti signaling protein (ASP), which is temporally expressed in wild-type mouse follicular melanocytes where it induces pheomelanin…”
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Interallelic Complementation at the Mouse Mitf Locus by Steingrimsson, Eirikur, Arnheiter, Heinz, Hallsson, Jon Hallsteinn, Lamoreux, M. Lynn, Copeland, Neal G, Jenkins, Nancy A

“…Mutations at the mouse microphthalmia locus (Mitf) affect the development of different cell types, including melanocytes, retinal pigment epithelial cells of…”
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Isolation, Chromosomal Mapping, and Expression of the Mouse Tyrosinase Gene by Kwon, Byoung S., Haq, Asifa K., Wakulchik, Mark, Kestler, Daniel, Barton, David E., Francke, Uta, Lynn Lamoreux, M., Barry Whitney, J., Halaban, Ruth

“…Using a human tyrosinase cDNA probe, we have isolated mouse tyrosinase genomic clones and used them to map the mouse tyrosinase locus and to analyze tile…”
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Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti by Dinulescu, D.M. (Oregon Health Sciences University, Portland, OR.), Fan, W, Boston, B.A, McCall, K, Lamoreux, M.L, Moore, K.J, Montagno, J, Cone, R.D

“…The mahogany (mg) locus originally was identified as a recessive suppressor of agouti, a locus encoding a skin peptide that modifies coat color by antagonizing…”
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Ocular pathology in mice with a transgenic insertion at the microphthalmia locus by Boissy, R E, Boissy, Y L, Krakowsky, J M, Lamoreux, M L, Lingrel, J B, Nordlund, J J

“…A DNA insertional mutation at the microphthalmia locus (mi) in a transgenic mouse has been developed and given the allele symbol of mitg (Krakowsky et al.,…”
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Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mi(ce)/mi(ce) mutant mice of which MITF lacks the zipper domain by Morii, E, Ogihara, H, Kim, D K, Ito, A, Oboki, K, Lee, Y M, Jippo, T, Nomura, S, Maeyama, K, Lamoreux, M L, Kitamura, Y

“…The mi transcription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factor that is important for the development of mast…”
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