Search Results - "Lamont, Douglas J"

Structural basis of PROTAC cooperative recognition for selective protein degradation by Gadd, Morgan S, Testa, Andrea, Lucas, Xavier, Chan, Kwok-Ho, Chen, Wenzhang, Lamont, Douglas J, Zengerle, Michael, Ciulli, Alessio

“…The description of the crystal structure of the Brd4 PROTAC compound MZ1 in complex with the human E3 ubiquitin ligase VHL and the Brd4 bromodomain shines new…”
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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation by Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Chen, Wenzhang, Lamont, Douglas J., Rocha, Sonia, Alessi, Dario R., Romeo, Roberto, Ciulli, Alessio

“…E3 ubiquitin ligases are key enzymes within the ubiquitin proteasome system which catalyze the ubiquitination of proteins, targeting them for proteasomal…”
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Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals by McMahon, Michael, Lamont, Douglas J., Beattie, Kenneth A., Hayes, John D., Murphy, Mike P.

“…Recognition and repair of cellular damage is crucial if organisms are to survive harmful environmental conditions. In mammals, the Keap1 protein orchestrates…”
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Cellular and Molecular Anatomy of the Human Neuromuscular Junction by Jones, Ross A., Harrison, Carl, Eaton, Samantha L., Llavero Hurtado, Maica, Graham, Laura C., Alkhammash, Leena, Oladiran, Oladayo A., Gale, Andy, Lamont, Douglas J., Simpson, Hamish, Simmen, Martin W., Soeller, Christian, Wishart, Thomas M., Gillingwater, Thomas H.

“…The neuromuscular junction (NMJ) plays a fundamental role in transferring information from lower motor neuron to skeletal muscle to generate movement. It is…”
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Mechanism of Activation of AMPK by Cordycepin by Hawley, Simon A, Ross, Fiona A, Russell, Fiona M, Atrih, Abdelmadjid, Lamont, Douglas J, Hardie, D Grahame

“…Cordycepin (3'-deoxyadenosine) is a major bioactive agent in Cordyceps militaris, a fungus used in traditional Chinese medicine. It has been proposed to have…”
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Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells by Lopez-Pelaez, Marta, Lamont, Douglas J., Peggie, Mark, Shpiro, Natalia, Gray, Nathanael S., Cohen, Philip

“…Significance NF-κB and IFN Regulatory Factor 5 (IRF5) are required for the transcription of many proinflammatory cytokines in myeloid cells. The protein kinase…”
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Phosphorylation of Arabidopsis UVR8 photoreceptor modulates protein interactions and responses to UV-B radiation by Liu, Wei, Giuriani, Giovanni, Havlikova, Anezka, Li, Dezhi, Lamont, Douglas J., Neugart, Susanne, Velanis, Christos N., Petersen, Jan, Hoecker, Ute, Christie, John M., Jenkins, Gareth I.

“…Exposure of plants to ultraviolet-B (UV-B) radiation initiates transcriptional responses that modify metabolism, physiology and development to enhance…”
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Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection by Gestuveo, Rommel J., Royle, Jamie, Donald, Claire L., Lamont, Douglas J., Hutchinson, Edward C., Merits, Andres, Kohl, Alain, Varjak, Margus

“…The escalating global prevalence of arboviral diseases emphasizes the need to improve our understanding of their biology. Research in this area has been…”
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Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib by Ross, Fiona A, Hawley, Simon A, Auciello, F Romana, Gowans, Graeme J, Atrih, Abdelmadjid, Lamont, Douglas J, Hardie, D Grahame

“…SU6656, a Src kinase inhibitor, was reported to increase fat oxidation and reduce body weight in mice, with proposed mechanisms involving AMP-activated protein…”
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Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation by Vara-Ciruelos, Diana, Dandapani, Madhumita, Russell, Fiona M., Grzes, Katarzyna M., Atrih, Abdelmadjid, Foretz, Marc, Viollet, Benoit, Lamont, Douglas J., Cantrell, Doreen A., Hardie, D. Grahame

“…AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and…”
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Reproducible Automated Phosphopeptide Enrichment Using Magnetic TiO2 and Ti-IMAC by Tape, Christopher J, Worboys, Jonathan D, Sinclair, John, Gourlay, Robert, Vogt, Janis, McMahon, Kelly M, Trost, Matthias, Lauffenburger, Douglas A, Lamont, Douglas J, Jørgensen, Claus

“…Reproducible, comprehensive phosphopeptide enrichment is essential for studying phosphorylation-regulated processes. Here, we describe the application of…”
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Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases by Dayalan Naidu, Sharadha, Sutherland, Calum, Zhang, Ying, Risco, Ana, de la Vega, Laureano, Caunt, Christopher J., Hastie, C. James, Lamont, Douglas J., Torrente, Laura, Chowdhry, Sudhir, Benjamin, Ivor J., Keyse, Stephen M., Cuenda, Ana, Dinkova-Kostova, Albena T.

“…Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of…”
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Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis by Cheratta, Anees Rahman, Thayyullathil, Faisal, Hawley, Simon A., Ross, Fiona A., Atrih, Abdelmajdid, Lamont, Douglas J., Pallichankandy, Siraj, Subburayan, Karthikeyan, Alakkal, Ameer, Rezgui, Rachid, Gray, Alex, Hardie, D. Grahame, Galadari, Sehamuddin

“…AMP-activated protein kinase (AMPK) coordinates energy homeostasis during metabolic and energy stress. We report that the catalytic subunit isoform AMPK-α1…”
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Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice by Kline, Rachel A., Dissanayake, Kosala N., Hurtado, Maica Llavero, Martínez, Nicolás W., Ahl, Alexander, Mole, Alannah J., Lamont, Douglas J., Court, Felipe A., Ribchester, Richard R., Wishart, Thomas M., Murray, Lyndsay M.

“…Neurodegenerative and neuromuscular disorders can manifest throughout the lifespan of an individual, from infant to elderly individuals. Axonal and synaptic…”
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Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture by Graham, Laura C, Eaton, Samantha L, Brunton, Paula J, Atrih, Abdelmadjid, Smith, Colin, Lamont, Douglas J, Gillingwater, Thomas H, Pennetta, Giuseppa, Skehel, Paul, Wishart, Thomas M

“…Neurons are highly polarized cells consisting of three distinct functional domains: the cell body (and associated dendrites), the axon and the synapse…”
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The Salmonella Kinase SteC Targets the MAP Kinase MEK to Regulate the Host Actin Cytoskeleton by Odendall, Charlotte, Rolhion, Nathalie, Förster, Andreas, Poh, John, Lamont, Douglas J., Liu, Mei, Freemont, Paul S., Catling, Andrew D., Holden, David W.

“…After host cell entry, Salmonella replicate in membrane-bound compartments, which accumulate a dense meshwork of F-actin through the kinase activity of the…”
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Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex by Laszlo, Zsofia I, Hindley, Nicole, Sanchez Avila, Anna, Kline, Rachel A, Eaton, Samantha L, Lamont, Douglas J, Smith, Colin, Spires-Jones, Tara L, Wishart, Thomas M, Henstridge, Christopher M

“…Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still…”
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Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo by Wishart, Thomas M, Rooney, Timothy M, Lamont, Douglas J, Wright, Ann K, Morton, A Jennifer, Jackson, Mandy, Freeman, Marc R, Gillingwater, Thomas H

“…Degeneration of synaptic and axonal compartments of neurons is an early event contributing to the pathogenesis of many neurodegenerative diseases, but the…”
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SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy by Wishart, Thomas M., Huang, Jack P.-W., Murray, Lyndsay M., Lamont, Douglas J., Mutsaers, Chantal A., Ross, Jenny, Geldsetzer, Pascal, Ansorge, Olaf, Talbot, Kevin, Parson, Simon H., Gillingwater, Thomas H.

“…Reduced expression of the survival motor neuron (SMN) gene causes the childhood motor neuron disease spinal muscular atrophy (SMA). Low levels of ubiquitously…”
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Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix by Mattos, Eliciane C, Canuto, Gisele, Manchola, Nubia C, Magalhães, Rubens D M, Crozier, Thomas W M, Lamont, Douglas J, Tavares, Marina F M, Colli, Walter, Ferguson, Michael A J, Alves, Maria Júlia M

“…Trypanosoma cruzi, the etiological agent of Chagas' disease, affects 8 million people predominantly living in socioeconomic underdeveloped areas. T. cruzi…”
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