Search Results - "Lamond, A I"

Structure and Function in the Nucleus by Lamond, Angus I., Earnshaw, William C.

“…Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene…”
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The conserved amino‐terminal domain of hSRP1 alpha is essential for nuclear protein import by Weis, K., Ryder, U., Lamond, A. I.

“…Nuclear proteins are targeted through the nuclear pore complex (NPC) in an energy‐dependent reaction. The import reaction is mediated by nuclear localization…”
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Herpes Simplex Virus IE63 (ICP27) Protein Interacts with Spliceosome-Associated Protein 145 and Inhibits Splicing prior to the First Catalytic Step by Bryant, H E, Wadd, S E, Lamond, A I, Silverstein, S J, Clements, J B

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells by Trinkle-Mulcahy, L, Sleeman, J E, Lamond, A I

“…Protein phosphatase 1 (PP1) is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma1, which are encoded by separate…”
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hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters by Miller, Gail, Panov, Kostya I., Friedrich, J.Karsten, Trinkle-Mulcahy, Laura, Lamond, Angus I., Zomerdijk, Joost C.B.M.

“…A crucial step in transcription is the recruitment of RNA polymerase to promoters. In the transcription of human rRNA genes by RNA Polymerase I (Pol I),…”
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Transcription-Dependent Colocalization of the U1, U2, U4/U6, and U5 snRNPs in Coiled Bodies by Carmo-Fonseca, Maria, Pepperkok, Rainer, Carvalho, Maria Teresa, Lamond, Angus I.

“…We have recently shown that discrete foci are present in the nuclei of mammalian cells in which each of the U1, U2, U4/U6, and U5 snRNPs involved in pre-mRNA…”
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PRCC, the commonest TFE3 fusion partner in papillary renal carcinoma is associated with pre-mRNA splicing factors by SKALSKY, Y. M, AJUH, P. M, PARKER, C, LAMOND, A. I, GOODWIN, G, COOPER, C. S

“…In papillary renal cell carcinomas the TFE3 transcription factor becomes fused to the PSF and NonO pre-mRNA splicing factors and most commonly to a protein of…”
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A Herpes Simplex Virus Type 1 Immediate-Early Gene Product, IE63, Regulates Small Nuclear Ribonucleoprotein Distribution by PHELAN, A, CARMO-FONSECA, M, MCLAUCHLAN, J, LAMOND, A. I, CLEMENTS, J. B

“…Herpes simplex virus 1 (HSV-1), a nuclear replicating DNA virus, has 73 identified genes of which only 4 contain introns. For this reason the virus probably…”
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Identification of hSRP1α as a Functional Receptor for Nuclear Localization Sequences by Weis, Karsten, Mattaj, Iain W., Lamond, Angus I.

“…Import of proteins into the nucleus is a two-step process, involving nuclear localization sequence (NLS)-dependent docking of the substrate at the nuclear…”
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The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway by Bailly, A, Perrin, A, Bou Malhab, L J, Pion, E, Larance, M, Nagala, M, Smith, P, O'Donohue, M-F, Gleizes, P-E, Zomerdijk, J, Lamond, A I, Xirodimas, D P

“…The ubiquitin-like molecule NEDD8 is essential for viability, growth and development, and is a potential target for therapeutic intervention. We found that the…”
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Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities by Weis, K., Dingwall, C., Lamond, A. I.

“…The small nuclear GTP binding protein Ran is required for transport of nuclear proteins through the nuclear pore complex (NPC). Although it is known that GTP…”
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Cloning and Intracellular Localization of the U2 Small Nuclear Ribonucleoprotein Auxiliary Factor Small Subunit by Zhang, Meng, Zamore, Phillip D., Carmo-Fonseca, Maria, Lamond, Angus I., Green, Michael R.

“…U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), an essential mammalian splicing factor, is composed of two subunits: a 65-kDa protein (U2AF65),…”
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Mammalian nuclei contain foci which are highly enriched in components of the pre‐mRNA splicing machinery by Carmo‐Fonseca, M, Tollervey, D, Pepperkok, R, Barabino, S. M, Merdes, A, Brunner, C, Zamore, P. D, Green, M. R, Hurt, E, Lamond, A. I

“…The organization of the major snRNP particles in mammalian cell nuclei has been analysed by in situ labelling using snRNA‐specific antisense probes made of…”
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The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif by WEIS, K, GRIFFITHS, G, LAMOND, A. I

“…We have identified a new human Ca(2+)-binding protein that is specifically localized in the endoplasmic reticulum (ER). The protein is termed ERC-55, i.e. ER…”
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Assembly of snRNP-Containing Coiled Bodies Is Regulated in Interphase and Mitosis: Evidence That the Coiled Body Is a Kinetic Nuclear Structure by Carmo-Fonseca, Maria, Ferreira, João, Lamond, Angus I.

“…Coiled bodies (CBs) are nuclear organelles in which splicing snRNPs concentrate. While CBs are sometimes observed in association with the nucleolar periphery,…”
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2'-O-Alkyl Oligoribonucleotides as Antisense Probes by Iribarren, Adolfo M., Sproat, Brian S., Neuner, Philippe, Sulston, Ingrid, Ryder, Ursula, Lamond, Angus I.

“…2'-O-Methyl oligoribonucleotides have recently been introduced as antisense probes for studying RNA processing and for affinity purification of RNA-protein…”
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Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing by Mermoud, Jacqueline E., Cohen, Philip, Lamond, Angus I.

“…We have used a combination of highly specific protein phosphatase Inhibitors and purified mammalian protein phosphatases to show that at least two separate…”
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Differential Interaction of Splicing snRNPs with Coiled Bodies and Interchromatin Granules during Mitosis and Assembly of Daughter Cell Nuclei by Ferreira, João A., Carmo-Fonseca, Maria, Lamond, Angus I.

“…In the interphase nucleus of mammalian cells the U1, U2, U4/U6, and U5 small nuclear ribonucleoproteins (snRNPs), which are subunits of spliceosomes, associate…”
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Spliceosome Assembly Involves the Binding and Release of U4 Small Nuclear Ribonucleoprotein by Lamond, Angus I., Konarska, Maria M., Grabowski, Paula J., Sharp, Phillip A.

“…Splicing complexes that form a rabbit β -globin precursor mRNA (pre-mRNA) have been analyzed for their small nuclear RNA (snRNA) content by both affinity…”
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Antisense oligonucleotides made of 2'- O-alkylRNA: their properties and applications in RNA biochemistry by Lamond, Angus I., Sproat, Brian S.

“…Oligo(2'- O-alkylribonucleotides) have been developed recently as novel oligonucleotide analogues with properties that enhance their use as antisense probes…”
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