Search Results - "Lammi, J"

Selenium-Related Transcriptional Regulation of Gene Expression by Lammi, Mikko J, Qu, Chengjuan

“…The selenium content of the body is known to control the expression levels of numerous genes, both so-called selenoproteins and non-selenoproteins. Selenium is…”
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Comparison of the major cell populations among osteoarthritis, Kashin–Beck disease and healthy chondrocytes by single-cell RNA-seq analysis by Wang, Xi, Ning, Yujie, Zhang, Pan, Poulet, Blandine, Huang, Ruitian, Gong, Yi, Hu, Minhan, Li, Cheng, Zhou, Rong, Lammi, Mikko J., Guo, Xiong

“…Chondrocytes are the key target cells of the cartilage degeneration that occurs in Kashin–Beck disease (KBD) and osteoarthritis (OA). However, the…”
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Challenges in Fabrication of Tissue-Engineered Cartilage with Correct Cellular Colonization and Extracellular Matrix Assembly by Lammi, Mikko J, Piltti, Juha, Prittinen, Juha, Qu, Chengjuan

“…A correct articular cartilage ultrastructure regarding its structural components and cellularity is important for appropriate performance of tissue-engineered…”
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Editorial: Genetic and environmental roles in bone and joint diseases by Lammi, Mikko J, Wang, Xi, Ning, Yujie

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Regulation of Oxygen Tension as a Strategy to Control Chondrocytic Phenotype for Cartilage Tissue Engineering and Regeneration by Lammi, Mikko J, Qu, Chengjuan

“…Cartilage defects and osteoarthritis are health problems which are major burdens on health care systems globally, especially in aging populations. Cartilage is…”
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Effects of long‐term low oxygen tension in human chondrosarcoma cells by Piltti, Juha, Bygdell, Joakim, Qu, Chengjuan, Lammi, Mikko J.

“…The cell‐based therapies could be potential methods to treat damaged cartilage tissues. Instead of native hyaline cartilage, the current therapies generate…”
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Three-Dimensional Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells Promotes Matrix Metallopeptidase 13 (MMP13) Expression in Type I Collagen Hydrogels by Oliveros Anerillas, Luis, Kingham, Paul J, Lammi, Mikko J, Wiberg, Mikael, Kelk, Peyman

“…Autologous bone transplantation is the principal method for reconstruction of large bone defects. This technique has limitations, such as donor site…”
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Alterations in the gut microbiota and metabolite profiles of patients with Kashin-Beck disease, an endemic osteoarthritis in China by Wang, Xi, Ning, Yujie, Li, Cheng, Gong, Yi, Huang, Ruitian, Hu, Minhan, Poulet, Blandine, Xu, Ke, Zhao, Guanghui, Zhou, Rong, Lammi, Mikko J., Guo, Xiong

“…Kashin-Beck disease (KBD) is a severe osteochondral disorder that may be driven by the interaction between genetic and environmental factors. We aimed to…”
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Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes by Lei, Yang, Guanghui, Zhao, Xi, Wang, Yingting, Wang, Xialu, Lin, Fangfang, Yu, Goldring, Mary B., Xiong, Guo, Lammi, Mikko J.

“…The relationship between T-2 toxin and deoxynivalenol (DON) and the risk of Kashin-Beck disease is still controversial since it is poorly known about their…”
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Chondrogenic differentiation of human pluripotent stem cells in chondrocyte co-culture by Qu, Chengjuan, Puttonen, Katja A., Lindeberg, Heli, Ruponen, Marika, Hovatta, Outi, Koistinaho, Jari, Lammi, Mikko J.

“…Chondrogenic differentiation of human embryonic (hESCs) or induced pluripotent stem cells (hiPSCs) has been achieved in embryoid bodies (EBs) by adding…”
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Involvement of Yes-Associated Protein 1 Activation in the Matrix Degradation of Human-Induced-Pluripotent-Stem-Cell-Derived Chondrocytes Induced by T-2 Toxin and Deoxynivalenol Alone and in Combination by Liu, Li, Liu, Huan, Meng, Peilin, Zhang, Yanan, Zhang, Feng'e, Jia, Yumeng, Cheng, Bolun, Lammi, Mikko J, Zhang, Feng, Guo, Xiong

“…T-2 toxin and deoxynivalenol (DON) are two prevalent mycotoxins that cause cartilage damage in Kashin-Beck disease (KBD). Cartilage extracellular matrix (ECM)…”
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Human milk secretory immunoglobulin a and lactoferrin N-glycans are altered in women with gestational diabetes mellitus by Smilowitz, Jennifer T, Totten, Sarah M, Huang, Jincui, Grapov, Dmitry, Durham, Holiday A, Lammi-Keefe, Carol J, Lebrilla, Carlito, German, J Bruce

“…Very little is known about the effects of gestational diabetes mellitus (GDM) on lactation and milk components. Recent reports suggested that hyperglycemia…”
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Comparative analysis of the gut microbiota composition between knee osteoarthritis and Kashin-Beck disease in Northwest China by Ning, Yujie, Hu, Minhan, Gong, Yi, Huang, Ruitian, Xu, Ke, Chen, Sijie, Zhang, Feiyu, Liu, Yanli, Chen, Feihong, Chang, Yanhai, Zhao, Guanghui, Li, Cheng, Zhou, Rong, Lammi, Mikko J, Guo, Xiong, Wang, Xi

“…Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure…”
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Blood Transfusions in Major Pancreatic Surgery: A 10-Year Cohort Study Including 1404 Patients Undergoing Pancreatic Resections in Finland by Lammi, J.-P., Eskelinen, M., Tuimala, J., Saarnio, J., Rantanen, T.

“…Background: Despite guidelines on blood transfusion (TF) thresholds, there seems to be great variation in transfusion policies between hospitals and surgeons…”
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ATAC-seq reveals the roles of chromatin accessibility in the chondrocytes of Kashin-Beck disease compared with primary osteoarthritis by Wang, Sen, Wang, Yuanji, Li, Xingyu, Yuan, Linlin, Guo, Xiong, Lammi, Mikko J

“…This study aimed to investigate the roles of accessible chromatin in understanding the different pathogeneses between Kashin-Beck disease (KBD) and primary…”
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Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study by Zhang, Yanan, Liu, Huan, Lin, Xialu, Zhang, Feng’e, Meng, Peilin, Tan, Sijia, Lammi, Mikko J., Guo, Xiong

“…Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is…”
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Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography by Karhula, Sakari S, Finnilä, Mikko A, Lammi, Mikko J, Ylärinne, Janne H, Kauppinen, Sami, Rieppo, Lassi, Pritzker, Kenneth P H, Nieminen, Heikki J, Saarakkala, Simo

“…Contrast-enhanced micro-computed tomography (CEμCT) with phosphotungstic acid (PTA) has shown potential for detecting collagen distribution of articular…”
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Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells by Piltti, Juha, Bygdell, Joakim, Fernández-Echevarría, Cecilia, Marcellino, Daniel, Lammi, Mikko J.

“…Articular chondrocytes are slowly dividing cells that tend to lose their cell type-specific phenotype and ability to produce structurally and functionally…”
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Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma by Wood, JodiAnne T., Williams, John S., Pandarinathan, Lakshmipathi, Janero, David R., Lammi-Keefe, Carol J., Makriyannis, Alexandros

“…The endocannabinoid metabolome consists of a growing, (patho)physiologically important family of fatty-acid derived signaling lipids. Diet is a major source of…”
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Perioperative changes in hemoglobin levels during major hepatopancreatic surgery in transfused and non-transfused patients by Lammi, J.P., Eskelinen, Matti, Tuimala, Jarno, Selander, Tuomas, Saarnio, Juha, Rantanen, Tuomo

“…Background: Several studies have shown that restrictive transfusion policies are safe. However, in clinical practice, transfusion policies seem to be…”
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