Nitrotyrosine in human neonatal spinal cord after perinatal asphyxia

Spinal cord injury has been reported after perinatal asphyxia in full-term neonates. To examine the role of excessive nitric oxide production in perinatal spinal cord injury. Tissue samples of 18 full-term neonates who died of hypoxic-ischemic encephalopathy were analyzed for the presence of nitroty...

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Bibliographic Details
Published in:	Neonatology (Basel, Switzerland) Vol. 93; no. 1; p. 1
Main Authors:	Groenendaal, Floris, Vles, Johannes, Lammers, Harry, De Vente, Jan, Smit, Diane, Nikkels, Peter G J
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-2008
Subjects:	Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Apoptosis Asphyxia Neonatorum - metabolism Asphyxia Neonatorum - pathology Autopsy Caspase 3 - metabolism Female Humans Hypoxia-Ischemia, Brain Infant, Newborn Inflammation Male Nitric Oxide - metabolism Spinal Cord - metabolism Spinal Cord - pathology Tyrosine - analogs & derivatives Tyrosine - metabolism
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Summary:	Spinal cord injury has been reported after perinatal asphyxia in full-term neonates. To examine the role of excessive nitric oxide production in perinatal spinal cord injury. Tissue samples of 18 full-term neonates who died of hypoxic-ischemic encephalopathy were analyzed for the presence of nitrotyrosine (NT). NT was demonstrated in 5 of these 18 neonates. In addition, activated caspase 3, a marker of apoptosis, and CD68, as a marker of inflammation, could be demonstrated in some infants. excessive nitric oxide production and subsequent NT formation is seen in spinal cord tissue after severe perinatal asphyxia. This finding may be relevant for the development of neuroprotective strategies.
ISSN:	1661-7819
DOI:	10.1159/000106432