Search Results - "Lamm, Ayelet T"

QsRNA-seq: a method for high-throughput profiling and quantifying small RNAs by Fishman, Alla, Light, Dean, Lamm, Ayelet T

“…The ability to profile and quantify small non-coding RNAs (sRNAs), specifically microRNAs (miRNAs), using high-throughput sequencing is challenging because of…”
Get full text

ADBP-1 regulates ADR-2 nuclear localization to control editing substrate selection by Eliad, Berta, Schneider, Noa, Ben-Naim Zgayer, Orna, Amichan, Yarden, Glaser, Fabian, Erdmann, Emily A, Rajendren, Suba, Hundley, Heather A, Lamm, Ayelet T

“…Abstract Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is a prevalent and conserved RNA modification. While A-to-I RNA editing is…”
Get full text

ADARs regulate cuticle collagen expression and promote survival to pathogen infection by Dhakal, Alfa, Salim, Chinnu, Skelly, Mary, Amichan, Yarden, Lamm, Ayelet T, Hundley, Heather A

“…In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and…”
Get full text

A-to-I RNA editing promotes developmental stage-specific gene and lncRNA expression by Goldstein, Boaz, Agranat-Tamir, Lily, Light, Dean, Ben-Naim Zgayer, Orna, Fishman, Alla, Lamm, Ayelet T

“…A-to-I RNA editing is a conserved widespread phenomenon in which adenosine (A) is converted to inosine (I) by adenosine deaminases (ADARs) in double-stranded…”
Get full text

Escherichia coli mediated resistance of Entamoeba histolytica to oxidative stress is triggered by oxaloacetate by Shaulov, Yana, Shimokawa, Chikako, Trebicz-Geffen, Meirav, Nagaraja, Shruti, Methling, Karen, Lalk, Michael, Weiss-Cerem, Lea, Lamm, Ayelet T, Hisaeda, Hajime, Ankri, Serge

“…Amebiasis, a global intestinal parasitic disease, is due to Entamoeba histolytica. This parasite, which feeds on bacteria in the large intestine of its human…”
Get full text

Distinct Phases of siRNA Synthesis in an Endogenous RNAi Pathway in C. elegans Soma by Gent, Jonathan I., Lamm, Ayelet T., Pavelec, Derek M., Maniar, Jay M., Parameswaran, Poornima, Tao, Li, Kennedy, Scott, Fire, Andrew Z.

“…Endogenous RNA-directed RNA polymerases (RdRPs) are cellular components capable of synthesizing new complementary RNAs from existing RNA templates. We present…”
Get full text

Competition between ADAR and RNAi pathways for an extensive class of RNA targets by Fire, Andrew Z, Wu, Diane, Lamm, Ayelet T

“…ADARs deaminate adenosines to inosines in double-stranded RNA (dsRNA). Interestingly, effects seen when ADARs are knocked out can be suppressed by additional…”
Get full text

RESIC: A Tool for Comprehensive Adenosine to Inosine RNA Editing Site Identification and Classification by Light, Dean, Haas, Roni, Yazbak, Mahmoud, Elfand, Tal, Blau, Tal, Lamm, Ayelet T.

“…Adenosine to inosine (A-to-I) RNA editing, the most prevalent type of RNA editing in metazoans, is carried out by adenosine deaminases (ADARs) in…”
Get full text

Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans by Cohen-Berkman, Moran, Dudkevich, Reut, Ben-Hamo, Shani, Fishman, Alla, Salzberg, Yehuda, Waldman Ben-Asher, Hiba, Lamm, Ayelet T, Henis-Korenblit, Sivan

“…How lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the…”
Get full text

Disruption in A-to-I Editing Levels Affects C. elegans Development More Than a Complete Lack of Editing by Ganem, Nabeel S., Ben-Asher, Noa, Manning, Aidan C., Deffit, Sarah N., Washburn, Michael C., Wheeler, Emily C., Yeo, Gene W., Zgayer, Orna Ben-Naim, Mantsur, Einav, Hundley, Heather A., Lamm, Ayelet T.

“…A-to-I RNA editing, catalyzed by ADAR proteins, is widespread in eukaryotic transcriptomes. Studies showed that, in C. elegans, ADR-2 can actively deaminate…”
Get full text

Co-option of the piRNA Pathway for Germline-Specific Alternative Splicing of C. elegans TOR by Barberán-Soler, Sergio, Fontrodona, Laura, Ribó, Anna, Lamm, Ayelet T., Iannone, Camilla, Cerón, Julián, Lehner, Ben, Valcárcel, Juan

“…Many eukaryotic genes contain embedded antisense transcripts and repetitive sequences of unknown function. We report that male germline-specific expression of…”
Get full text

Function of cancer associated genes revealed by modern univariate and multivariate association tests by Gorfine, Malka, Goldstein, Boaz, Fishman, Alla, Heller, Ruth, Heller, Yair, Lamm, Ayelet T

“…Copy number variation (CNV) plays a role in pathogenesis of many human diseases, especially cancer. Several whole genome CNV association studies have been…”
Get full text

In cancer, A-to-I RNA editing can be the driver, the passenger, or the mechanic by Ganem, Nabeel S., Ben-Asher, Noa, Lamm, Ayelet T.

“…In recent years, A-to-I RNA modifications performed by the Adenosine Deaminase Acting on RNA (ADAR) protein family were found to be expressed at altered levels…”
Get full text

A-to-I RNA editing - thinking beyond the single nucleotide by Ganem, Nabeel S., Lamm, Ayelet T.

“…Adenosine-to-inosine RNA editing is a conserved process, which is performed by ADAR enzymes. By changing nucleotides in coding regions of genes and altering…”
Get full text

BAF-1 mobility is regulated by environmental stresses by Bar, Daniel Z, Davidovich, Maya, Lamm, Ayelet T, Zer, Hagit, Wilson, Katherine L, Gruenbaum, Yosef

“…Barrier to autointegration factor (BAF) is an essential component of the nuclear lamina that binds lamins, LEM-domain proteins, histones, and DNA. Under normal…”
Get full text

Multimodal RNA-seq using single-strand, double-strand, and CircLigase-based capture yields a refined and extended description of the C. elegans transcriptome by Lamm, Ayelet T, Stadler, Michael R, Zhang, Huibin, Gent, Jonathan I, Fire, Andrew Z

“…We have used a combination of three high-throughput RNA capture and sequencing methods to refine and augment the transcriptome map of a well-studied genetic…”
Get full text

QsRNA-seq: A protocol for generating libraries for high-throughput sequencing of small RNAs by Fishman, Alla, T Lamm, Ayelet

“…Small RNAs (sRNAs) are 20-30 nt long non-coding RNA molecules that regulate essentially all cellular processes. Besides being an intensively studied topic in…”
Get full text

Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis by Barkan, Rachel, Zahand, Adam J, Sharabi, Kfir, Lamm, Ayelet T, Feinstein, Naomi, Haithcock, Erin, Wilson, Katherine L, Liu, Jun, Gruenbaum, Yosef

“…Emerin and LEM2 are ubiquitous inner nuclear membrane proteins conserved from humans to Caenorhabditis elegans. Loss of human emerin causes Emery-Dreifuss…”
Get full text

A-to-I RNA Editing Affects lncRNAs Expression after Heat Shock by Haas, Roni, Ganem, Nabeel S, Keshet, Ayya, Orlov, Angela, Fishman, Alla, Lamm, Ayelet T

“…Adenosine to inosine (A-to-I) RNA editing is a highly conserved regulatory process carried out by adenosine-deaminases (ADARs) on double-stranded RNA (dsRNAs)…”
Get full text

Function of Cancer Associated Genes Revealed by Modern Univariate and Multivariate Association Tests: e0126544 by Gorfine, Malka, Goldstein, Boaz, Fishman, Alla, Heller, Ruth, Heller, Yair, Lamm, Ayelet T

“…Copy number variation (CNV) plays a role in pathogenesis of many human diseases, especially cancer. Several whole genome CNV association studies have been…”
Get full text