Search Results - "Lamlum, H."

APC Mutations in Sporadic Colorectal Tumors: A Mutational "Hotspot" and Interdependence of the "Two Hits" by Rowan, A. J., Lamlum, H., Ilyas, M., Wheeler, J., Straub, J., Papadopoulou, A., Bicknell, D., Bodmer, W. F., Tomlinson, I. P. M.

“…Although APC mutations occur at a high frequency in colorectal cancers, few studies have performed a comprehensive analysis by screening the whole gene for…”
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Prognostic and Predictive Molecular Markers in Colorectal Carcinoma by BENUARDAF, R, LAMLUM, H, PYRHÖNEN, S

“…Tumour markers are molecules occurring in blood or tissue that are associated with cancer and whose measurement or identification is useful in patient…”
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Whole-Gene APC Deletions Cause Classical Familial Adenomatous Polyposis, but not Attenuated Polyposis or "Multiple" Colorectal Adenomas by Sieber, O. M., Lamlum, H., Crabtree, M.D., Rowan, A. J., Barclay, E., Lipton, L., Hodgson, S., Thomas, H. J. W., Neale, K., Phillips, R. K. S., Farrington, S. M., Dunlop, M. G., Mueller, H. J., Bisgaard, M. L., Bulow, S., Fidalgo, P., Albuquerque, C., Scarano, M. I., Bodmer, W., Tomlinson, I. P. M., Heinimann, K.

“…Familial adenomatous polyposis (FAP) is a dominantly inherited colorectal tumor predisposition that results from germ-line mutations in the APC gene…”
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Analysis of Chromosomal Instability in Human Colorectal Adenomas with Two Mutational Hits at APC by Sieber, O. M., Heinimann, K., Gorman, P., Lamlum, H., Crabtree, M., Simpson, C. A., Davies, D., Neale, K., Hodgson, S. V., Roylance, R. R., Phillips, R. K. S., Bodmer, W. F., Tomlinson, I. P. M.

“…In vitro data show that the adenomatous polyposis coli (APC) protein associates with the mitotic spindle and that mouse embryonic stem cells with biallelic Apc…”
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Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q by LAMLUM, Hanan, AL TASSAN, Nada, WILLIAMS, Christopher, GILBERT, John, CHEADLE, Jeremy, BELL, Jennie, HOULSTON, Richard, BODMER, Walter, SAMPSON, Julian, TOMLINSON, Ian, JAEGER, Emma, FRAYLING, Ian, SIEBER, Oliver, FAISAL BIN REZA, ECKERT, Maria, ROWAN, Andrew, BARCLAY, Ella, ATKIN, Wendy

“…Mendelian tumour syndromes are caused by rare mutations, which usually lead to protein inactivation. Few studies have determined whether or not the same genes…”
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Comparison of CD44 expression in primary tumours and metastases of colorectal cancer by BENDARDAF, R, ALGARS, A, ELZAGHEID, A, KORKEILA, E, RISTAMÄKI, R, LAMLUM, H, COLLAN, Y, SYRJÄNEN, K, PYRHÖNEN, S

“…A better understanding on the development of a metastatic phenotype in colorectal cancer (CRC) is essential to help identify patients at high risk for…”
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E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer by Bendardaf, R, Elzagheid, A, Lamlum, H, Ristamäki, R, Collan, Y, Pyrhönen, S

“…Cell adhesion molecules (CAMs) are cell surface glycoproteins that are important in cell-cell and cell-matrix interactions and play an important role in cell…”
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Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases by Bendardaf, R, Lamlum, H, Ristamäki, R, Korkeila, E, Syrjänen, K, Pyrhönen, S

“…Colorectal cancer (CRC) cell lines displaying microsatellite instability (MSI) are resistant to 5-fluorouracil (5-FU) in vitro, which can be overcome by…”
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Mismatch repair status is a predictive factor of tumour response to 5-fluorouracil and irinotecan chemotherapy in patients with advanced colorectal cancer by Bendardaf, R, Lamlum, H, Ristamäki, R, Korkeila, E, Syrjänen, K, Pyrhönen, S

“…To determine the association between DNA mismatch repair (MMR) protein expression and response to chemotherapy in patients with advanced colorectal cancer…”
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Thymidylate synthase expression levels: a prognostic and predictive role in advanced colorectal cancer by Bendardaf, R, Lamlum, H, Elzagheid, A, Ristamäki, R, Pyrhönen, S

“…Thymidylate synthase (TS) is the rate-limiting enzyme in the synthesis of pyrimidine nucleotides, required for DNA synthesis, and is also a critical target for…”
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Low collagenase-1 (MMP-1) and MT1-MMP expression levels are favourable survival markers in advanced colorectal carcinoma by Bendardaf, R, Lamlum, H, Vihinen, P, Ristamäki, R, Laine, J, Pyrhönen, S

“…Extracellular matrix degradation is required for invasive growth and metastasis formation in colorectal carcinoma; therefore, we examined matrix…”
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CD44 variant 6 expression predicts response to treatment in advanced colorectal cancer by Bendardaf, R, Lamlum, H, Ristamäki, R, Pyrhönen, S

“…CD44 has diverse functions in cell-cell and cell-matrix interactions and may be a determinant of metastatic and invasive behaviour in carcinomas. CD44 variant…”
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Apoptotic index and bcl-2 expression as prognostic factors in colorectal carcinoma by Bendardaf, R, Ristamäki, R, Kujari, H, Laine, J, Lamlum, H, Collan, Y, Pyrhönen, S

“…To examine programmed cell death in 57 colorectal carcinomas (49 primary tumours and 8 metastases) and determine the prognostic significance of apoptosis in…”
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Response to chemotherapy (irinotecan plus 5-fluorouracil) in colorectal carcinoma can be predicted by tumour DNA content by Bendardaf, R, Lamlum, H, Ristamäki, R, Algars, A, Collan, Y, Pyrhönen, S

“…The aim of this study was to identify markers that might predict response to chemotherapy. Postoperative chemotherapy improves the outcome in stage III colon…”
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The androgen receptor exon 1 trinucleotide repeat does not act as a modifier of the age of presentation in breast cancer by Given, H.F., Radbourne, R., Oag, H., Merritt, S., Barclay, E., Hanby, A.M., Lamlum, H., McGrath, J., Curran, C., Tomlinson, I.P.M.

“…The CAG repeat in exon 1 of the androgen receptor ( AR) genes has been postulated as both a susceptibility allele and phenotypic modifier in BRCA1-associated…”
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The association of combined alpha and beta fibrinogen genotype on plasma fibrinogen levels in smokers and non-smokers by Thomas, A E, Green, F R, Lamlum, H, Humphries, S E

“…OBJECTIVE--To determine in healthy men: (1) whether an extended genotype of the fibrinogen gene cluster using the G/A-455 and the BclI polymorphism of the beta…”
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Characterization of a dinucleotide repeat in the 92 kDa type IV collagenase gene (CLG4B), localization of CLG4B to chromosome 20 and the role of CLG4B in aortic aneurysmal disease by St Jean, P L, Zhang, X C, Hart, B K, Lamlum, H, Webster, M W, Steed, D L, Henney, A M, Ferrell, R E

“…Proteolytic imbalance may play a role in the pathogenesis of abdominal aortic aneurysms (AAA). CLG4B, which encodes the 92-kDa form of type IV collagenase, is…”
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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer by Tomlinson, Ian P M, Alam, N Afrina, Rowan, Andrew J, Barclay, Ella, Jaeger, Emma E M, Kelsell, David, Leigh, Irene, Gorman, Patricia, Lamlum, Hanan, Rahman, Shamima, Roylance, Rebecca R, Olpin, Simon, Bevan, Stephen, Barker, Karen, Hearle, Nicholas, Houlston, Richard S, Kiuru, Maija, Lehtonen, Rainer, Karhu, Auli, Vilkki, Susa, Laiho, Päivi, Eklund, Carita, Vierimaa, Outi, Aittomäki, Kristiina, Hietala, Marja, Sistonen, Pertti, Paetau, Anders, Salovaara, Reijo, Herva, Riitta, Launonen, Virpi, Aaltonen, Lauri A

“…Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is known about their etiology and pathogenesis. We previously mapped a…”
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The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis by Tomlinson, Ian, Lamlum, Hanan, Ilyas, Mohammad, Rowan, Andrew, Clark, Susan, Johnson, Victoria, Bell, Jennie, Frayling, Ian, Efstathiou, Jason, Pack, Kevin, Payne, Stewart, Roylance, Rebecca, Gorman, Patricia, Sheer, Denise, Neale, Kay, Phillips, Robin, Talbot, Ian, Bodmer, Walter

“…APC is often cited as a prime example of a tumor suppressor gene. Truncating germline and somatic mutations (or, infrequently, allelic loss) occur in tumors in…”
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Mutation Cluster Region, Association Between Germline and Somatic Mutations and Genotype-Phenotype Correlation in Upper Gastrointestinal Familial Adenomatous Polyposis by Groves, Christopher, Lamlum, Hanan, Crabtree, Michael, Williamson, Jill, Taylor, Claire, Bass, Sylvia, Cuthbert-Heavens, Darren, Hodgson, Shirley, Phillips, Robin, Tomlinson, Ian

“…Studies of adenomatous polyposis coli ( APC ) mutations in familial adenomatous polyposis (FAP) have focused on large bowel disease. It has been found that: 1)…”
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