Search Results - "Lamichhane, Tika Ram"

Refine Results
  1. 1

    Structural changes in thyroid hormone receptor-beta by T3 binding and L330S mutational interactions by Ram Lamichhane, Tika, Prasad Lamichhane, Hari

    Published in AIMS biophysics (01-01-2020)
    “…The point mutations like L330S in the ligand binding domain (LBD) of thyroid hormone receptor-beta (THR-β) make the structural changes as reflected by…”
    Get full text
    Journal Article
  2. 2

    Heat conduction by thyroid hormone receptors by Ram Lamichhane, Tika, Prasad Lamichhane, Hari

    Published in AIMS biophysics (01-01-2018)
    “…Thyroid hormone receptors (THRs) together with hormone binding and dissociation are important in gene expressions. The heat conduction properties such as heat…”
    Get full text
    Journal Article
  3. 3

    Identification of potential human pancreatic α-amylase inhibitors from natural products by molecular docking, MM/GBSA calculations, MD simulations, and ADMET analysis by Basnet, Santosh, Ghimire, Madhav Prasad, Lamichhane, Tika Ram, Adhikari, Rajendra, Adhikari, Achyut

    Published in PloS one (16-03-2023)
    “…Human pancreatic α-amylase (HPA), which works as a catalyst for carbohydrate hydrolysis, is one of the viable targets to control type 2 diabetes. The…”
    Get full text
    Journal Article
  4. 4

    Identification of lead inhibitors for 3CLpro of SARS-CoV-2 target using machine learning based virtual screening, ADMET analysis, molecular docking and molecular dynamics simulations by Chhetri, Sandeep Poudel, Bhandari, Vishal Singh, Maharjan, Rajesh, Lamichhane, Tika Ram

    Published in RSC advances (12-09-2024)
    “…The SARS-CoV-2 3CLpro is a critical target for COVID-19 therapeutics due to its role in viral replication. We employed a screening pipeline to identify novel…”
    Get full text
    Journal Article
  5. 5
  6. 6

    Artemisinin derivatives as potential drug candidates against Mycobacterium tuberculosis: insights from molecular docking, MD simulations, PCA, MM/GBSA and ADMET analysis by Maharjan, Rajesh, Gyawali, Kalpana, Acharya, Arjun, Khanal, Madan, Ghimire, Madhav Prasad, Lamichhane, Tika Ram

    Published in Molecular simulation (23-07-2024)
    “…Tuberculosis, one of the most ancient and formidable infectious diseases, primarily arises from the pathogenic bacterium Mycobacterium tuberculosis (Mtb)…”
    Get full text
    Journal Article
  7. 7

    Gamma-ray, fast neutron and ion shielding characteristics of low-density and high-entropy Mg–Al–Ti–V–Cr–Fe–Zr–Nb alloy systems using Phy-X/PSD and SRIM programs by Subedi, Basanta, Paudel, Jeevan, Lamichhane, Tika Ram

    Published in Heliyon (01-07-2023)
    “…This study aimed to assess the radiation shielding properties of ten low-density high-entropy alloys (LWHEAs) using Phy-X/PSD software to analyze various…”
    Get full text
    Journal Article
  8. 8

    Evaluation of SARS-CoV-2 main protease and inhibitor interactions using dihedral angle distributions and radial distribution function by Lamichhane, Tika Ram, Ghimire, Madhav Prasad

    Published in Heliyon (01-10-2021)
    “…In order to evaluate the interactions between a potential drug candidate like inhibitor N3 and the residues in substrate binding site of SARS-CoV-2 main…”
    Get full text
    Journal Article
  9. 9

    Echo dephasing and heat capacity from constrained and unconstrained dynamics of triiodothyronine nuclear receptor protein by Lamichhane, Tika Ram, Paudel, Sharma, Yadav, Binod Kumar, Lamichhane, Hari Prasad

    Published in Journal of biological physics (01-03-2019)
    “…The objective of this study is to observe the echo feature curves, vibrational dephasing, and heat capacity of a protein–hormone system taking thyroid hormone…”
    Get full text
    Journal Article
  10. 10

    Experimental FTIR characterization of kidney stones, DFT analysis of CaC2O4 and its interactions with lysozyme by Acharya, Arjun, Khanal, Madan, Maharjan, Rajesh, Gyawali, Kalpana, Khanal, Kamal, Kshetri, Mohan Bahadur, Luitel, Bhoj Raj, Adhikari, Rameshwar, Mulmi, Deependra Das, Lamichhane, Tika Ram, Lamichhane, Hari Prasad

    Published in Bibechana (03-10-2024)
    “…Kidney stone is an alarming global disease due to its rising incidence and prevalence. FTIR spectroscopic analysis reveals that calcium oxalate is one of the…”
    Get full text
    Journal Article
  11. 11
  12. 12

    Constant velocity pulling and unfolding of thyroid hormone receptor by steered molecular dynamics by Lamichhane, Tika Ram, Lamichhane, Hari Prasad

    Published in Bibechana (01-01-2020)
    “…Unfolding pathways of T3 liganded thyroid hormone receptor (THRT3) can be studied by using the protocols of steered molecular dynamics (SMD). Theory of…”
    Get full text
    Journal Article
  13. 13

    Analysis of second wave of COVID-19 cases in Nepal with a logistic model by Joshi, Radha Krishna, Bhatt, Sarita, Lamichhane, Tika Ram, Ghimire, Madhav Prasad

    Published in Asian Journal of Medical Sciences (01-10-2021)
    “…Background: COVID-19, caused by SARS-CoV-2, is a newly identified highly infectious disease. It has affected almost every country including Nepal causing a…”
    Get full text
    Journal Article
  14. 14

    Molecular dynamics approach to the I431V mutational impact on thyroid hormone receptor-beta by Lamichhane, Tika Ram, Paudel, Sharma, Yadav, Binod Kumar, Lamichhane, Hari Prasad

    Published in Bibechana (22-11-2018)
    “…The point mutations like I431V on thyroid hormone receptor-beta (THR-β) gene cause resistance to thyroid hormones (RTH) with the clinical diagnosis of elevated…”
    Get full text
    Journal Article
  15. 15

    Radiation shielding properties of low-density Ti-based bulk metallic glass composites: a computational study by Subedi, Basanta, Lamichhane, Tika Ram

    Published in Physica scripta (01-03-2023)
    “…Bulk metallic glasses (BMGs), a new class of structural and functional materials with unique physical and chemical features like high corrosion resistance,…”
    Get full text
    Journal Article
  16. 16

    Identification of potential human pancreatic [alpha]-amylase inhibitors from natural products by molecular docking, MM/GBSA calculations, MD simulations, and ADMET analysis by Basnet, Santosh, Ghimire, Madhav Prasad, Lamichhane, Tika Ram, Adhikari, Rajendra, Adhikari, Achyut

    Published in PloS one (16-03-2023)
    “…Human pancreatic [alpha]-amylase (HPA), which works as a catalyst for carbohydrate hydrolysis, is one of the viable targets to control type 2 diabetes. The…”
    Get full text
    Journal Article
  17. 17

    Identification of catechin as main protease inhibitor of SARS-CoV-2 Omicron variant using molecular docking, molecular dynamics, PCA, DCCM, MM/GBSA and ADMET profiling by Gyawali, Kalpana, Maharjan, Rajesh, Acharya, Arjun, Khanal, Madan, Ghimire, Madhav Prasad, Lamichhane, Tika Ram

    Published in Natural product research (02-11-2024)
    “…The Omicron variant of SARS-CoV-2 spreads more rapidly than other variants and can affect even vaccinated individuals. The Omicron variant main protease…”
    Get full text
    Journal Article
  18. 18
  19. 19

    Constant velocity pulling and unfolding of thyroid hormone receptor by steered molecular dynamics by Tika Ram Lamichhane, Hari Prasad Lamichhane

    Published in Bibechana (01-01-2020)
    “…Unfolding pathways of T3 liganded thyroid hormone receptor (THRT3) can be studied by using the protocols of steered molecular dynamics (SMD). Theory of…”
    Get full text
    Journal Article
  20. 20