Search Results - "Lamfers, Martine L.M."

DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors by Mazor, Tali, Pankov, Aleksandr, Johnson, Brett E., Hong, Chibo, Hamilton, Emily G., Bell, Robert J.A., Smirnov, Ivan V., Reis, Gerald F., Phillips, Joanna J., Barnes, Michael J., Idbaih, Ahmed, Alentorn, Agusti, Kloezeman, Jenneke J., Lamfers, Martine L.M., Bollen, Andrew W., Taylor, Barry S., Molinaro, Annette M., Olshen, Adam B., Chang, Susan M., Song, Jun S., Costello, Joseph F.

“…The evolutionary history of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast to stable genetic events, epigenetic…”
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Local delivery of hrBMP4 as an anticancer therapy in patients with recurrent glioblastoma: a first-in-human phase 1 dose escalation trial by Bos, Eelke M, Binda, Elena, Verploegh, Iris S C, Wembacher, Eva, Hoefnagel, Daphna, Balvers, Rutger K, Korporaal, Anne L, Conidi, Andrea, Warnert, Esther A H, Trivieri, Nadia, Visioli, Alberto, Zaccarini, Paola, Caiola, Laura, van Wijck, Rogier, van der Spek, Peter, Huylebroeck, Danny, Leenstra, Sieger, Lamfers, Martine L M, Ram, Zvi, Westphal, Manfred, Noske, David, Legnani, Federico, DiMeco, Francesco, Vescovi, Angelo Luigi, Dirven, Clemens M F

“…This Phase 1 study evaluates the intra- and peritumoral administration by convection enhanced delivery (CED) of human recombinant Bone Morphogenetic Protein 4…”
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The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells by Berghauser Pont, Lotte M E, Kleijn, Anne, Kloezeman, Jenneke J, van den Bossche, Wouter, Kaufmann, Johanna K, de Vrij, Jeroen, Leenstra, Sieger, Dirven, Clemens M F, Lamfers, Martine L M

“…A phase I/II trial for glioblastoma with the oncolytic adenovirus Delta24-RGD was recently completed. Delta24-RGD conditionally replicates in cells with a…”
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DNA damage response and anti-apoptotic proteins predict radiosensitization efficacy of HDAC inhibitors SAHA and LBH589 in patient-derived glioblastoma cells by Berghauser Pont, Lotte M.E, Naipal, Kishan, Kloezeman, Jenneke J, Venkatesan, Subramanian, van den Bent, Martin, van Gent, Dik C, Dirven, Clemens M.F, Kanaar, Roland, Lamfers, Martine L.M, Leenstra, Sieger

“…Abstract HDAC inhibitors have radiosensitizing effects in established cancer cell lines. This study was conducted to compare the efficacy of SAHA, LBH589,…”
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Malignant Glioma In Vitro Models: On the Utilization of Stem-like Cells by Balvers, Rutger K, Dirven, Clemens M F, Leenstra, Sieger, Lamfers, Martine L M

“…Recent publications on the molecular characterization of malignant glioma have had profound impact on the appreciation of tumoral heterogeneity within and…”
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The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8+T Cell Anti-tumor Activity by Kleijn, Anne, van den Bossche, Wouter, Haefner, Erik S., Belcaid, Zineb, Burghoorn-Maas, Chantal, Kloezeman, Jenneke J., Pas, Suzan D., Leenstra, Sieger, Debets, Reno, de Vrij, Jeroen, Dirven, Clemens M.F., Lamfers, Martine L.M.

“…The conditionally replicating oncolytic adenovirus Delta24-RGD (Ad) is currently under investigation in clinical trials for glioblastoma, including in…”
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Cyclophosphamide Increases Transgene Expression Mediated by an Oncolytic Adenovirus in Glioma-Bearing Mice Monitored by Bioluminescence Imaging by Lamfers, Martine L M, Fulci, Giulia, Gianni, Davide, Tang, Yi, Kurozumi, Kazuhiko, Kaur, Balveen, Moeniralm, Sharif, Saeki, Yoshinaga, Carette, Jan E, Weissleder, Ralph, Vandertop, W Peter, van Beusechem, Victor W, Dirven, Clemens M F, Chiocca, E Antonio

“…Approaches to improve the oncolytic potency of replication-competent adenoviruses include the insertion of therapeutic transgenes into the viral genome. Little…”
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Differential Effects of Combined Ad5-Δ24RGD and Radiation Therapy in In vitro versus In vivo Models of Malignant Glioma by Lamfers, Martine L.M., Idema, Sander, Bosscher, Lisette, Heukelom, Stan, Moeniralm, Sharif, van der Meulen-Muileman, Ida H., Overmeer, Renée M., van der Valk, Paul, van Beusechem, Victor W., Gerritsen, Winald R., Vandertop, W. Peter, Dirven, Clemens M.F.

“…Purpose: The integrin-targeted conditionally replicating adenovirus Ad5-Δ24RGD has been shown to possess strong oncolytic activity in experimental tumors and…”
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Locally-delivered T-cell-derived cellular vehicles efficiently track and deliver adenovirus delta24-RGD to infiltrating glioma by Balvers, Rutger K, Belcaid, Zineb, van den Hengel, Sanne K, Kloezeman, Jenneke, de Vrij, Jeroen, Wakimoto, Hiroaki, Hoeben, Rob C, Debets, Reno, Leenstra, Sieger, Dirven, Clemens, Lamfers, Martine L M

“…Oncolytic adenoviral vectors are a promising alternative for the treatment of glioblastoma. Recent publications have demonstrated the advantages of shielding…”
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Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma by LAMFERS, Martine L. M, GIANNI, Davide, ANTONIO CHIOCCA, E, GERRITSEN, Winald R, TUNG, Ching-Hsuan, IDEMA, Sander, SCHAGEN, Frederik H. E, CARETTE, Jan E, QUAX, Paul H. A, VAN BEUSECHEM, Victor W, PETER VANDERTOP, W, DIRVEN, Clemens M. F

“…Oncolytic adenoviruses exhibiting tumor-selective replication are promising anticancer agents. Insertion and expression of a transgene encoding tissue…”
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Neurosurgical delivery of chemotherapeutics, targeted toxins, genetic and viral therapies in neuro-oncology by CHIOCCA, E. Antonio, BROADDUS, William C, GILLIES, George T, VISTED, Therese, LAMFERS, Martine L. M

“…Local delivery of biologic agents, such as gene and viruses, has been tested preclinically with encouraging success, and in some instances clinical trials have…”
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Adenoviral Activin A Expression Prevents Intimal Hyperplasia in Human and Murine Blood Vessels by Maintaining the Contractile Smooth Muscle Cell Phenotype by Engelse, Marten A, Lardenoye, JanWillem H.P, Neele, Jolanda M, Grimbergen, Jos M, de Vries, Margreet R, Lamfers, Martine L.M, Pannekoek, Hans, Quax, Paul H.A, de Vries, Carlie J.M

“…Activin A alters the characteristics of human arterial smooth muscle cells (SMCs) toward a contractile, quiescent phenotype. We hypothesize that activin A may…”
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3D‐Engineered Scaffolds to Study Microtubes and Localization of Epidermal Growth Factor Receptor in Patient‐Derived Glioma Cells by Barin, Nastaran, Balcioglu, Hayri E., de Heer, Iris, de Wit, Maurice, Lamfers, Martine L. M., van Royen, Martin E., French, Pim J., Accardo, Angelo

“…A major obstacle in glioma research is the lack of in vitro models that can retain cellular features of glioma cells in vivo. To overcome this limitation, a…”
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Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies by van Putten, Erik H P, Kleijn, Anne, van Beusechem, Victor W, Noske, David, Lamers, Cor H J, de Goede, Anna L, Idema, Sander, Hoefnagel, Daphna, Kloezeman, Jenneke J, Fueyo, Juan, Lang, Frederick F, Teunissen, Charlotte E, Vernhout, René M, Bakker, Cathy, Gerritsen, Winald, Curiel, David T, Vulto, Arnold, Lamfers, Martine L M, Dirven, Clemens M F

“…Testing safety of Delta24-RGD (DNX-2401), an oncolytic adenovirus, locally delivered by convection enhanced delivery (CED) in tumor and surrounding brain of…”
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Advancements, Challenges, and Future Directions in Tackling Glioblastoma Resistance to Small Kinase Inhibitors by Fabro, Federica, Lamfers, Martine L M, Leenstra, Sieger

“…Despite clinical intervention, glioblastoma (GBM) remains the deadliest brain tumor in adults. Its incurability is partly related to the establishment of drug…”
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Developing oncolytic viruses for clinical use: A consortium approach by Kemp, Vera, Lamfers, Martine L.M., van der Pluijm, Gabri, van den Hoogen, Bernadette G., Hoeben, Rob C.

“…[Display omitted] •The use of oncolytic viruses is a powerful approach to stimulate anti-tumor immune responses.•Development of oncolytic new viruses requires…”
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The Multifaceted Role of Macrophages in Oncolytic Virotherapy by Hofman, Laura, Lawler, Sean E, Lamfers, Martine L M

“…One of the cancer hallmarks is immune evasion mediated by the tumour microenvironment (TME). Oncolytic virotherapy is a form of immunotherapy based on the…”
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Oncolytic virotherapy in glioblastoma patients induces a tumor macrophage phenotypic shift leading to an altered glioblastoma microenvironment by van den Bossche, Wouter B L, Kleijn, Anne, Teunissen, Charlotte E, Voerman, Jane S A, Teodosio, Cristina, Noske, David P, van Dongen, Jacques J M, Dirven, Clemens M F, Lamfers, Martine L M

“…Immunosuppressive protumoral M2 macrophages are important in pathogenesis, progression, and therapy resistance in glioblastoma (GBM) and provide a target for…”
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Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response by Stavrakaki, Eftychia, Dirven, Clemens M F, Lamfers, Martine L M

“…Oncolytic virus (OV) treatment may offer a new treatment option for the aggressive brain tumor glioblastoma. Clinical trials testing oncolytic viruses in this…”
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Drug Repurposing, a Fast-Track Approach to Develop Effective Treatments for Glioblastoma by Ntafoulis, Ioannis, Koolen, Stijn L. W., Leenstra, Sieger, Lamfers, Martine L. M.

“…Glioblastoma (GBM) remains one of the most difficult tumors to treat. The mean overall survival rate of 15 months and the 5-year survival rate of 5% have not…”
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