Search Results - "Lamers, C. B."

Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer by KUBBEN, F. J. G. M, SIER, C. F. M, MEIJER, M. J. W, VAN DEN BERG, M, VAN DER REIJDEN, J. J, GRIFFIOEN, G, VAN DE VELDE, C. J. H, LAMERS, C. B. H. W, VERSPAGET, H. W

“…Gastric cancers express enhanced levels of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Single-nucleotide polymorphisms (SNPs) in MMP…”
Get full text

Development of mAb-based polyglutamine-dependent and polyglutamine length-independent huntingtin quantification assays with cross-site validation by Fischer, David F, Dijkstra, Sipke, Lo, Kimberly, Suijker, Johnny, Correia, Ana C P, Naud, Patricia, Poirier, Martin, Tessari, Michela A, Boogaard, Ivette, Flynn, Geraldine, Visser, Mijke, Lamers, Marieke B A C, McAllister, George, Munoz-Sanjuan, Ignacio, Macdonald, Douglas

“…Huntington's disease (HD) is caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin gene that results in expression of a mutant…”
Get full text

Quantification assays for total and polyglutamine-expanded huntingtin proteins by Macdonald, Douglas, Tessari, Michela A, Boogaard, Ivette, Smith, Melanie, Pulli, Kristiina, Szynol, Agnieszka, Albertus, Faywell, Lamers, Marieke B A C, Dijkstra, Sipke, Kordt, Daniel, Reindl, Wolfgang, Herrmann, Frank, McAllister, George, Fischer, David F, Munoz-Sanjuan, Ignacio

“…The expansion of a CAG trinucleotide repeat in the huntingtin gene, which produces huntingtin protein with an expanded polyglutamine tract, is the cause of…”
Get full text

Endoscopic regression of Barrett’s oesophagus during omeprazole treatment; a randomised double blind study by Peters, F T M, Ganesh, S, Kuipers, E J, Sluiter, W J, Klinkenberg-Knol, E C, Lamers, C B H W, Kleibeuker, J H

“…BACKGROUND Barrett’s oesophagus, columnar metaplasia of the epithelium, is a premalignant condition with a 50–100-fold increased risk of cancer. The condition…”
Get full text

MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not by Langers, A M J, Sier, C F M, Hawinkels, L J A C, Kubben, F J G M, van Duijn, W, van der Reijden, J J, Lamers, C B H W, Hommes, D W, Verspaget, H W

“…The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer…”
Get full text

Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237 by Sloane, Dominic A, Trikic, Michael Z, Chu, Matthew L. H, Lamers, Maria B. A. C, Mason, Clive S, Mueller, Ilka, Savory, Wendy J, Williams, David H, Eyers, Patrick A

“…The Aurora kinases regulate multiple aspects of mitotic progression, and their overexpression in diverse tumor types makes them appealing oncology targets. An…”
Get full text

An overview of the current diagnosis and recent developments in neuroendocrine tumours of the gastroenteropancreatic tract: the diagnostic approach by KUIPER, P, VERSPAGET, H. W, OVERBEEK, L. I. H, BIEMOND, I, LAMERS, C. B

“…Neuroendocrine tumours of the gastroenteropancreatic tract (GEP-NETs) comprise a group of very heterogeneous neoplasms, which are considered 'rare diseases'…”
Get full text

Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer by KUBBEN, F. J. G. M, SIER, C. F. M, VAN DUIJN, W, GRIFFIOEN, G, HANEMAAIJER, R, VAN DE VELDE, C. J. H, VAN KRIEKEN, J. H. J. M, LAMERS, C. B. H. W, VERSPAGET, H. W

“…In a pioneer study, we showed 10 years ago that enhanced tissue levels of the matrix metalloproteinases (MMPs) MMP-2 and MMP-9 in gastric cancers, as…”
Get full text

Gender-Related Differences in the Clinical Course of Crohn's Disease by Wagtmans, M. J., Verspaget, H. W., Lamers, C. B. H. W., van Hogezand, R. A.

“…The aim of this study was to analyze the clinical and epidemiological differences between women and men affected by Crohn's disease. The clinical course of 275…”
Get full text

Individualized population pharmacokinetic model with limited sampling for cyclosporine monitoring after liver transplantation in clinical practice by LANGERS, P., CREMERS, S. C. L. M., DEN HARTIGH, J., RIJNBEEK, E. M. T., RINGERS, J., LAMERS, C. B. H. W., HOMMES, D. W., VAN HOEK, B.

“…Summary Background  We recently developed and validated limited sampling models (LSMs) for cyclosporine monitoring after orthotopic liver transplantation based…”
Get full text

Substance p receptor expression in patients with inflammatory bowel disease determination by three different techniques, i.e., storage phosphor autoradiography, RT-PCR and immunohistochemistry by TER BEEK, W. P, BIEMOND, I, MULLER, E. S. M, VAN DEN BERG, M, LAMERS, C. B. H. W

“…Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation accompanied by changes in motility. It is known that regulatory peptides…”
Get full text

Motor and sensory function of the proximal stomach in reflux disease and after laparoscopic Nissen fundoplication by Vu, M K, Straathof, J W A, Schaar, P J v d, Arndt, J W, Ringers, J, Lamers, C B H W, Masclee, A A M

“…After Nissen fundoplication, dyspeptic symptoms such as fullness and early satiety develop in >30% of patients. These symptoms may result from alterations in…”
Get full text

Provocation of transient lower esophageal sphincter relaxations by gastric distension with air by Straathof, J W A, Ringers, J, Lamers, C B H W, Masclee, A A M

“…Transient lower esophageal sphincter relaxations (TLESRs) are the major mechanism permitting not only gastroesophageal reflux but also venting of air from the…”
Get full text

Satiety effects of a physiological dose of cholecystokinin in humans by Lieverse, R J, Jansen, J B, Masclee, A A, Lamers, C B

“…Cholecystokinin 33 (CCK) was infused intravenously to eight healthy obese women and 10 healthy lean women of the same age, in doses that elicited plasma…”
Get full text

Cholecystokinin receptors in human pancreas and gallbladder muscle: A comparative study by Tang, C, Biemond, I, Lamers, CB

“…BACKGROUND & AIMS: Cholecystokinin (CCK) receptors mediate pancreatic secretion and gallbladder contraction. Hitherto, little information on characteristics of…”
Get full text

[1,2,4]Triazolo[1,5‑a]pyrimidine Phosphodiesterase 2A Inhibitors: Structure and Free-Energy Perturbation-Guided Exploration by Tresadern, Gary, Velter, Ingrid, Trabanco, Andrés A, Van den Keybus, Frans, Macdonald, Gregor J, Somers, Marijke V. F, Vanhoof, Greet, Leonard, Philip M, Lamers, Marieke B. A. C, Van Roosbroeck, Yves E. M, Buijnsters, Peter J. J. A

“…We describe the hit-to-lead exploration of a [1,2,4]­triazolo­[1,5-a]­pyrimidine phosphodiesterase 2A (PDE2A) inhibitor arising from high-throughput screening…”
Get full text

Long-term results of octreotide-therapy in severe dumping syndrome by Vecht, J., Lamers, C. B. H. W., Masclee, A. A. M.

“…OBJECTIVE Little is known about the long‐term results of octreotide therapy in dumping syndrome. We report the results of an open study including 20 patients…”
Get full text

Easy‐to‐use, accurate and flexible individualized Bayesian limited sampling method without fixed time points for ciclosporin monitoring after liver transplantation by Langers, P., Cremers, S. C. L. M., Hartigh, J., Rijnbeek, E. M. T., Ringers, J., Lamers, C. B. H. W., Hoek, B.

“…Summary Background : New methods to estimate the systemic exposure to ciclosporin such as the level 2 h after dosing and limited sampling formulas may lead to…”
Get full text

Prospective study of the effect of laparoscopic hemifundoplication on motor and sensory function of the proximal stomach by Vu, M. K., Ringers, J., Arndt, J. W., Lamers, C. B. H. W., Masclee, A. A. M.

“…Background: Some 30 per cent of patients develop dyspeptic symptoms following antireflux surgery. These symptoms may result from alterations in the motor and…”
Get full text

Superoxide dismutases in the human colorectal cancer sequence by JANSSEN, A. M. L, BOSMAN, C. B, KRUIDENIER, L, GRIFFIOEN, G, LAMERS, C. B. H. W, VAN KRIEKEN, J. H. J. M, VAN DE VELDE, C. J. H, VERSPAGET, H. W

“…The oxidant-antioxidant balance within tissues is thought to contribute to the development and progression of cancer. Previous investigations have indicated…”
Get full text