Search Results - "Lambris, J.D."

Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention by Mastellos, D.C., Ricklin, D., Hajishengallis, E., Hajishengallis, G., Lambris, J.D.

“…Summary There is increasing appreciation that complement dysregulation lies at the heart of numerous immune‐mediated and inflammatory disorders. Complement…”
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Complement activation triggered by chondroitin sulfate released by thrombin receptor‐activated platelets by HAMAD, O.A., EKDAHL, K.N., NILSSON, P.H., ANDERSSON, J., MAGOTTI, P., LAMBRIS, J.D., NILSSON, B.

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Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β by Ignatius, Anita, Schoengraf, Philipp, Kreja, Ludwika, Liedert, Astrid, Recknagel, Stefan, Kandert, Sebastian, Brenner, Rolf E., Schneider, Marion, Lambris, John D., Huber-Lang, Markus

“…There is a tight interaction of the bone and the immune system. However, little is known about the relevance of the complement system, an important part of…”
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Differential capacity for complement receptor‐mediated immune evasion by Porphyromonas gingivalis depending on the type of innate leukocyte by Hajishengallis, G., Krauss, J.L., Jotwani, R., Lambris, J.D.

“…Summary The complement system plays a central role in immunity and inflammation, although certain pathogens can exploit complement to undermine protective…”
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Combined inhibition of C3 and CD14 attenuates the inflammatory reaction significantly more as compared to single inhibition by Egge, K.H., Thorgersen, E.B., Lindstad, J.K., Pharo, A.M., Lambris, J.D., Barratt-Due, A., Mollnes, T.E.

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Key role of tissue factor in complement-mediated coagulation activation by Escherichia coli and LPS by Brekke, O.-L., Landsem, A., Fure, H., Christiansen, D., Waage-Nielsen, E., Lambris, J.D., Mollnes, T.E.

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Key role of CD14 in the E. coli- and LPS-induced mRNA down regulation of the C5a receptors CD88 and C5L2 by Fure, H., Brekke, O.L., Lambris, J.D., Mollnes, T.E.

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C5L2-mediated signals control contraction of human Th1 responses by Fara, A., Sumner, J., Kolev, M., Roberts, C., Lappegård, K.T., Garred, P., Arno, M., Lavender, P., Lambris, J.D., Mollnes, T.E., Köhl, J., Kemper, C.

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Cholesterol crystals activate the complement system and are phagocytosed in a complement-dependent manner by Nymo, S., Samstad, E.O., Niyonzima, N., Aune, M.H., Bergseth, G., Ryan, L., Brekke, O.-L., Latz, E., Lambris, J.D., Espevik, T., Mollnes, T.E.

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An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood by Danielsson, A, Elgue, G, Nilsson, B M, Nilsson, B, Lambris, J D, Tötterman, T H, Kochanek, S, Kreppel, F, Essand, M

“…Polyethylene glycol coating (PEGylation) of adenovirus serotype 5 (Ad5) has been shown to effectively reduce immunogenicity and increase circulation time of…”
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Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb‐C and its complement target C3d by Haspel, Nurit, Ricklin, Daniel, Geisbrecht, Brian V., Kavraki, Lydia E., Lambris, John D.

“…The C3–inhibitory domain of Staphylococcus aureus extracellular fibrinogen‐binding protein (Efb‐C) defines a novel three‐helix bundle motif that regulates…”
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Differential effect of inhibiting MD-2 and CD14 on LPS- versus whole E. coli bacteria-induced cytokine responses in human blood by Christiansen, D., Brekke, O.L., Stenvik, J., Lambris, J.D., Espevik, T., Mollnes, T.E.

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Pathogen-instigated subversive crosstalk between complement and Toll-like receptors by Hajishengallis, G., Wang, M., Krauss, J.L., Domon, H., Hosur, K.B., Liang, S., Magotti, P., Triantafilou, M., Triantafilou, K., Lambris, J.D.

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Ornithodoros moubata complement inhibitor (OmCI) is an equally effective C5 inhibitor in pig and human, and combined with CD14 inhibition, efficiently attenuate Escherichia coli-induced sepsis in pigs by Barratt-Due, A., Thorgersen, E.B., Lindstad, J.K., Pharo, A., Lambris, J.D., Nunn, M.A., Mollnes, T.E.

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C1 inhibitor efficiently inhibits Escherichia coli and LPS-induced tissue factor expression on monocytes and mRNA upregulation in human whole blood by Fure, H.F., Landsem, A., Christiansen, D., Brekke, O.L., Nielsen, E.W., Lambris, J.D., Mollnes, T.E.

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CD59 Efficiently Protects Human NT2-N Neurons Against Complement-mediated Damage by Pedersen, E.D, Aass, H.C.D, Rootwelt, T, Fung, M, Lambris, J.D, Mollnes, T.E

“…The complement regulatory protein CD59 controls cell survival by the inhibition of C5b-9 formation on the cell membrane. Loss of CD59 increases the…”
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Improvement of the anti-C3 activity of compstatin using rational and combinatorial approaches by Morikis, D, Soulika, A M, Mallik, B, Klepeis, J L, Floudas, C A, Lambris, J D

“…Compstatin is a 13-residue cyclic peptide that has the ability to inhibit the cleavage of C3 to C3a and C3b. The effects of targeting C3 cleavage are…”
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Complement is essential for phenotypic shift of leukocytes to a pro-inflammatory and pro-thrombotic state in a whole blood model of sepsis: Evidence from genetically complement-deficient patients by Lappegård, K.T., Christiansen, D., Fadnes, D., Abrahamsen, T., Salvesen, B., Lambris, J.D., Mollnes, T.E.

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From atoms to systems: a cross-disciplinary approach to complement-mediated functions by Mastellos, D, Morikis, D, Strey, C, Holland, M.C, Lambris, J.D

“…With an ever-increasing wealth of information made available to researchers from expanding genomic sequence and protein structure databases, traditional…”
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Drusen complement components C3a and C5a promote choroidal neovascularization by Nozaki, M., Raisler, B.J., Sakurai, E., Sarma, J.V., Barnum, S.R., Lambris, J.D., Chen, Y., Zhang, K., Ambati, B.K., Baffi, J.Z., Ambati, J.

“…The earliest clinical hallmark of age-related macular degeneration (AMD) is the presence of drusen, extracellular deposits that accumulate beneath the retinal…”
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