Search Results - "Lambris, J. D."

Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention by Mastellos, D.C., Ricklin, D., Hajishengallis, E., Hajishengallis, G., Lambris, J.D.

“…Summary There is increasing appreciation that complement dysregulation lies at the heart of numerous immune‐mediated and inflammatory disorders. Complement…”
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Differential capacity for complement receptor‐mediated immune evasion by Porphyromonas gingivalis depending on the type of innate leukocyte by Hajishengallis, G., Krauss, J.L., Jotwani, R., Lambris, J.D.

“…Summary The complement system plays a central role in immunity and inflammation, although certain pathogens can exploit complement to undermine protective…”
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The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent by Lappegård, K. T., Bergseth, G., Riesenfeld, J., Pharo, A., Magotti, P., Lambris, J. D., Mollnes, T. E.

“…Exposing blood to an artificial surface results in a systemic inflammatory response, including cytokine release and complement activation. We studied the…”
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An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood by Danielsson, A, Elgue, G, Nilsson, B M, Nilsson, B, Lambris, J D, Tötterman, T H, Kochanek, S, Kreppel, F, Essand, M

“…Polyethylene glycol coating (PEGylation) of adenovirus serotype 5 (Ad5) has been shown to effectively reduce immunogenicity and increase circulation time of…”
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A Novel Role of Complement: Mice Deficient in the Fifth Component of Complement (C5) Exhibit Impaired Liver Regeneration by Mastellos, Dimitrios, Papadimitriou, John C, Franchini, Silvia, Tsonis, Panagiotis A, Lambris, John D

“…Components of innate immunity have recently been implicated in the regulation of developmental processes. Most strikingly, complement factors appear to be…”
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Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library by Sahu, A, Kay, BK, Lambris, JD

“…We have screened a phage-displayed random peptide library for binding to C3b, the proteolytically activated form of complement component C3, and have…”
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Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics by Sahu, Arvind, Lambris, John D

“…In addition to its essential role in immune defense, the complement system contributes to tissue damage in many clinical conditions. Thus, there is a pressing…”
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Structural aspects and design of low-molecular-mass complement inhibitors by Morikis, D, Lambris, J D

“…We present a mini-review on the structure-based design of three promising complement inhibitors. Firstly, we review compstatin, a 13-residue cyclic peptide…”
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Complement C5a‐Induced Changes in Neutrophil Morphology During Inflammation by Denk, S., Taylor, R. P., Wiegner, R., Cook, E. M., Lindorfer, M. A., Pfeiffer, K., Paschke, S., Eiseler, T., Weiss, M., Barth, E., Lambris, J. D., Kalbitz, M., Martin, T., Barth, H., Messerer, D. A. C., Gebhard, F., Huber‐Lang, M. S.

“…The complement and neutrophil defence systems, as major components of innate immunity, are activated during inflammation and infection. For neutrophil…”
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Binding Kinetics, Structure-Activity Relationship, and Biotransformation of the Complement Inhibitor Compstatin by Sahu, Arvind, Soulika, Athena M, Morikis, Dimitrios, Spruce, Lynn, Moore, William T, Lambris, John D

“…We have previously identified a 13-residue cyclic peptide, Compstatin, that binds to complement component C3 and inhibits complement activation. Herein, we…”
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Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry by Whitbeck, J C, Peng, C, Lou, H, Xu, R, Willis, S H, Ponce de Leon, M, Peng, T, Nicola, A V, Montgomery, R I, Warner, M S, Soulika, A M, Spruce, L A, Moore, W T, Lambris, J D, Spear, P G, Cohen, G H, Eisenberg, R J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Diet-induced hepatocellular carcinoma in genetically predisposed mice by Hill-Baskin, Annie E., Markiewski, Maciej M., Buchner, David A., Shao, Haifeng, DeSantis, David, Hsiao, Gene, Subramaniam, Shankar, Berger, Nathan A., Croniger, Colleen, Lambris, John D., Nadeau, Joseph H.

“…Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide, with ∼70% of cases resulting from hepatitis B and C viral infections,…”
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Compstatin inhibits complement and cellular activation in whole blood in two models of extracorporeal circulation by NILSSON, B, LARSSON, R, JAAN HONG, ELGUE, G, EKDAHL, K. N, SAHU, A, LAMBRIS, J. D

“…Recently, a C3-binding cyclic synthetic peptide (Compstatin) has been identified that binds to complement component C3 and inhibits complement activation. Here…”
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Complement activation triggered by chondroitin sulfate released by thrombin receptor‐activated platelets by HAMAD, O. A., EKDAHL, K. N., NILSSON, P. H., ANDERSSON, J., MAGOTTI, P., LAMBRIS, J. D., NILSSON, B.

“…Background: Chondroitin sulfate (CS) is a glycosaminoglycan released by activated platelets. Objective: Here we test the hypothesis that CS released by…”
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Kinetic Analysis of the Interactions of Complement Receptor 2 (CR2, CD21) with Its Ligands C3d, iC3b, and the EBV Glycoprotein gp350/220 by Sarrias, Maria Rosa, Franchini, Silvia, Canziani, Gabriela, Argyropoulos, Emelia, Moore, William T, Sahu, Arvind, Lambris, John D

“…The molecular mechanisms involved in the interaction of complement receptor 2 (CR2) with its natural ligands iC3b and C3d are still not well understood. In…”
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Complement inhibition in a xenogeneic model of interactions between human whole blood and porcine endothelium by Kourtzelis, I, Ferreira, A, Mitroulis, I, Ricklin, D, Bornstein, S R, Waskow, C, Lambris, J D, Chavakis, T

“…Xenotransplantation (xeno-Tx) is considered as an alternative solution to overcome the shortage of human donor organs. However, the success of xeno-Tx is…”
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Multiple Forms of Complement C3 in Trout that Differ in Binding to Complement Activators by Sunyer, J. Oriol, Zarkadis, Ioannis K., Sahu, Arvind, Lambris, John D.

“…In all other species analyzed to date, the functionally active form of complement component C3 exists as the product of a single gene. We have now identified…”
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Solution structure of Compstatin, a potent complement inhibitor by Morikis, Dimitrios, Assa‐Munt, Nuria, Sahu, Arvind, Lambris, John D.

“…The third component of complement, C3, plays a central role in activation of the classical, alternative, and lectin pathways of complement activation…”
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Structure and biology of complement protein C3, a connecting link between innate and acquired immunity by Sahu, Arvind, Lambris, John D.

“…Complement protein C3 is a central molecule in the complement system whose activation is essential for all the important functions performed by this system…”
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Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells by Smith, CI, Baskin, B, Humire-Greiff, P, Zhou, JN, Olsson, PG, Maniar, HS, Kjellen, P, Lambris, JD, Christensson, B, Hammarstrom, L

“…The gene mutated in the human disease, X-linked agammaglobulinemia (XLA), is related to the Src gene family of cytoplasmic protein-tyrosine kinases and is…”
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