Search Results - "Lambright, Christy R"

A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner by Howdeshell, Kembra L., Wilson, Vickie S., Furr, Johnathan, Lambright, Christy R., Rider, Cynthia V., Blystone, Chad R., Hotchkiss, Andrew K., Gray, Leon Earl

“…Phthalate diesters are chemicals to which humans are ubiquitously exposed. Exposure to certain phthalates during sexual differentiation causes reproductive…”
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Pubertal Administration of DEHP Delays Puberty, Suppresses Testosterone Production, and Inhibits Reproductive Tract Development in Male Sprague-Dawley and Long-Evans Rats by Noriega, Nigel C., Howdeshell, Kembra L., Furr, Jonathan, Lambright, Christy R., Wilson, Vickie S., Gray, L. Earl

“…Although is clear that exposure to high dosage levels of some phthalates delays the onset of puberty in the male rat, it has been hypothesized that low levels…”
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Cumulative Effects of In Utero Administration of Mixtures of “Antiandrogens” on Male Rat Reproductive Development by Rider, Cynthia V., Wilson, Vickie S., Howdeshell, Kembra L., Hotchkiss, Andrew K., Furr, Johnathan R., Lambright, Christy R., Earl Gray, L.

“…Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 Food Quality Protection Act (FQPA) required the Environmental…”
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Dose Addition Models Based on Biologically Relevant Reductions in Fetal Testosterone Accurately Predict Postnatal Reproductive Tract Alterations by a Phthalate Mixture in Rats by Howdeshell, Kembra L, Rider, Cynthia V, Wilson, Vickie S, Furr, Johnathan R, Lambright, Christy R, Gray, Jr, L Earl

“…Challenges in cumulative risk assessment of anti-androgenic phthalate mixtures include a lack of data on all the individual phthalates and difficulty…”
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Gestational and Lactational Exposure to Ethinyl Estradiol, but not Bisphenol A, Decreases Androgen-Dependent Reproductive Organ Weights and Epididymal Sperm Abundance in the Male Long Evans Hooded Rat by Howdeshell, Kembra L., Furr, Johnathan, Lambright, Christy R., Wilson, Vickie S., Ryan, Bryce C., Gray, L. Earl

“…Many chemicals released into the environment are capable of disrupting normal sex steroid balance, including the oral contraceptive ethinyl estradiol (EE) and…”
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Cumulative Effects of Dibutyl Phthalate and Diethylhexyl Phthalate on Male Rat Reproductive Tract Development: Altered Fetal Steroid Hormones and Genes by Howdeshell, Kembra L., Furr, Johnathan, Lambright, Christy R., Rider, Cynthia V., Wilson, Vickie S., Gray, L. Earl

“…Exposure to plasticizers di(n-butyl) phthalate (DBP) and diethylhexyl phthalate (DEHP) during sexual differentiation causes male reproductive tract…”
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The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat by PARKS, Louise G, OSTBY, Joe S, LAMBRIGHT, Christy R, ABBOTT, Barbara D, KLINEFELTER, Gary R, BARLOW, Norman J, GRAY, L. Earl

“…Phthalate esters (PE) such as DEHP are high production volume plasticizers used in vinyl floors, food wraps, cosmetics, medical products, and toys. In spite of…”
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A Novel Cell Line, MDA-kb2, That Stably Expresses an Androgen- and Glucocorticoid-Responsive Reporter for the Detection of Hormone Receptor Agonists and Antagonists by Wilson, Vickie S., Bobseine, Kathy, Lambright, Christy R., Gray, L. E.

“…The U.S. Environmental Protection Agency has proposed that in vitro assays for estrogen receptor (ER)- and androgen receptor (AR)-mediated actions be included…”
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The herbicide linuron reduces testosterone production from the fetal rat testis during both in utero and in vitro exposures by Wilson, Vickie S., Lambright, Christy R., Furr, Johnathan R., Howdeshell, Kembra L., Earl Gray, L.

“…In utero exposure to linuron, an urea-based herbicide, results in a pattern of malformations of androgen-dependent tissues in adult male rat offspring…”
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Differences in sensitivity but not selectivity of xenoestrogen binding to alligator versus human estrogen receptor alpha by Rider, Cynthia V., Hartig, Phillip C., Cardon, Mary C., Lambright, Christy R., Bobseine, Kathy L., Guillette Jr, Louis J., Gray Jr, L. Earl, Wilson, Vickie S.

“…Reproductive abnormalities in alligators exposed to contaminants in Lake Apopka, Florida, USA represent a clear example of endocrine disruption in wildlife…”
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In Utero Exposure to Di(n)butyl Phthalate Reduces Testicular Testosterone and Testes Size in a Dose-Dependent Manner in Harlan Sprague Dawley Fetal Rats by Howdeshell, Kembra L., Furr, Johnathan, Lambright, Christy R., Wilson, Vickie, Gray, L. Earl

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Vinclozolin and p,p'-DDE alter androgen-dependent gene expression: in vivo confirmation of an androgen receptor -mediated mechanism by Kelce, W.R. (U.S. Environmental Protection Agency, Research Triangle Park, NC.), Lambright, C.R, Gray, L.E. Jr, Roberts, K.P

“…Vinclozolin and p,p'-DDE induce antiandrogenic developmental effects in vivo and are potent inhibitors of androgen receptor (AR) binding and AR-dependent gene…”
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DNA Arrays to Monitor Gene Expression in Rat Blood and Uterus following 17β-Estradiol Exposure: Biomonitoring Environmental Effects Using Surrogate Tissues by Rockett, John C., Kavlock, Robert J., Lambright, Christy R., Parks, Louise G., Schmid, Judith E., Wilson, Vickie S., Wood, Carmen, Dix, David J.

“…We propose that gene expression changes in accessible tissues such as blood often reflect those in inaccessible tissues, thus offering a convenient…”
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DNA arrays to monitor gene expression in rat blood and uterus following 17beta-estradiol exposure: biomonitoring environmental effects using surrogate tissues by Rockett, John C, Kavlock, Robert J, Lambright, Christy R, Parks, Louise G, Schmid, Judith E, Wilson, Vickie S, Wood, Carmen, Dix, David J

“…We propose that gene expression changes in accessible tissues such as blood often reflect those in inaccessible tissues, thus offering a convenient…”
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Vinclozolin andp,p′-DDE Alter Androgen-Dependent Gene Expression:In VivoConfirmation of an Androgen Receptor-Mediated Mechanism by Kelce, William R., Lambright, Christy R., Gray, L.Earl, Roberts, Kenneth P.

“…Vinclozolin andp,p′-DDE induce antiandrogenic developmental effectsin vivoand are potent inhibitors of androgen receptor (AR) binding and AR-dependent gene…”
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