Search Results - "Lambkin, Robert"

randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus by DeVincenzo, John, Lambkin-Williams, Robert, Wilkinson, Tom, Cehelsky, Jeffrey, Nochur, Sara, Walsh, Edward, Meyers, Rachel, Gollob, Jared, Vaishnaw, Akshay

“…RNA interference (RNAi) is a natural mechanism regulating protein expression that is mediated by small interfering RNAs (siRNA). Harnessing RNAi has potential…”
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Oral GS-5806 Activity in a Respiratory Syncytial Virus Challenge Study by DeVincenzo, John P, Whitley, Richard J, Mackman, Richard L, Scaglioni-Weinlich, Cecilia, Harrison, Lisa, Farrell, Eric, McBride, Stephen, Lambkin-Williams, Robert, Jordan, Robert, Xin, Yan, Ramanathan, Srini, O’Riordan, Thomas, Lewis, Sandra A, Li, Xiaoming, Toback, Seth L, Lin, Shao-Lee, Chien, Jason W

“…Respiratory syncytial virus is a common cause of illness and hospitalization, especially among infants and immunocompromised persons, but there are no accepted…”
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Influenza A (H3) illness and viral aerosol shedding from symptomatic naturally infected and experimentally infected cases by Bueno de Mesquita, Paul Jacob, Nguyen‐Van‐Tam, Jonathan, Killingley, Ben, Enstone, Joanne, Lambkin‐Williams, Robert, Gilbert, Anthony S., Mann, Alexander, Forni, John, Yan, Jing, Pantelic, Jovan, Grantham, Michael L., Milton, Donald K.

“…Background It has long been known that nasal inoculation with influenza A virus produces asymptomatic to febrile infections. Uncertainty persists about whether…”
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The Effect of Influenza Virus on the Human Oropharyngeal Microbiome by Ramos-Sevillano, Elisa, Wade, William G, Mann, Alex, Gilbert, Anthony, Lambkin-Williams, Robert, Killingley, Ben, Nguyen-Van-Tam, Jonathan S, Tang, Christoph M

“…Abstract Background Secondary bacterial infections are an important cause of morbidity and mortality associated with influenza infections. As bacterial disease…”
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Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification by Sobel Leonard, Ashley, McClain, Micah T, Smith, Gavin J D, Wentworth, David E, Halpin, Rebecca A, Lin, Xudong, Ransier, Amy, Stockwell, Timothy B, Das, Suman R, Gilbert, Anthony S, Lambkin-Williams, Robert, Ginsburg, Geoffrey S, Woods, Christopher W, Koelle, Katia

“…Knowledge of influenza virus evolution at the point of transmission and at the intrahost level remains limited, particularly for human hosts. Here, we analyze…”
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A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2 by Woods, Christopher W, McClain, Micah T, Chen, Minhua, Zaas, Aimee K, Nicholson, Bradly P, Varkey, Jay, Veldman, Timothy, Kingsmore, Stephen F, Huang, Yongsheng, Lambkin-Williams, Robert, Gilbert, Anthony G, Hero, 3rd, Alfred O, Ramsburg, Elizabeth, Glickman, Seth, Lucas, Joseph E, Carin, Lawrence, Ginsburg, Geoffrey S

“…There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of…”
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Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment by Nguyen-Van-Tam, Jonathan S, Killingley, Ben, Enstone, Joanne, Hewitt, Michael, Pantelic, Jovan, Grantham, Michael L, Bueno de Mesquita, P Jacob, Lambkin-Williams, Robert, Gilbert, Anthony, Mann, Alexander, Forni, John, Noakes, Catherine J, Levine, Min Z, Berman, LaShondra, Lindstrom, Stephen, Cauchemez, Simon, Bischoff, Werner, Tellier, Raymond, Milton, Donald K

“…Uncertainty about the importance of influenza transmission by airborne droplet nuclei generates controversy for infection control. Human challenge-transmission…”
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Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection by Rennie, Paul, Bowtell, Philip, Hull, David, Charbonneau, Duane, Lambkin-Williams, Robert, Oxford, John

“…Developing strategies for controlling the severity of pandemic influenza is a global public health priority. In the event of a pandemic there may be a place…”
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Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection by Burke, Thomas W., Henao, Ricardo, Soderblom, Erik, Tsalik, Ephraim L., Thompson, J. Will, McClain, Micah T., Nichols, Marshall, Nicholson, Bradly P., Veldman, Timothy, Lucas, Joseph E., Moseley, M. Arthur, Turner, Ronald B., Lambkin-Williams, Robert, Hero, Alfred O., Woods, Christopher W., Ginsburg, Geoffrey S.

“…Infection of respiratory mucosa with viral pathogens triggers complex immunologic events in the affected host. We sought to characterize this response through…”
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A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses by McClain, Micah T., Nicholson, Bradly P., Park, Lawrence P., Liu, Tzu-Yu, Hero, Alfred O., Tsalik, Ephraim L., Zaas, Aimee K., Veldman, Timothy, Hudson, Lori L., Lambkin-Williams, Robert, Gilbert, Anthony, Burke, Thomas, Nichols, Marshall, Ginsburg, Geoffrey S., Woods, Christopher W.

“…Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in…”
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A Throat Lozenge Containing Amyl Meta Cresol and Dichlorobenzyl Alcohol Has a Direct Virucidal Effect on Respiratory Syncytial Virus, Influenza a and SARS-CoV by Oxford, John S, Lambkin, Robert, Gibb, Iain, Balasingam, Shobana, Chan, Charlotte, Catchpole, Andrew

“…A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory…”
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Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community by Yan, Jing, Grantham, Michael, Pantelic, Jovan, de Mesquita, P. Jacob Bueno, Albert, Barbara, Liu, Fengjie, Ehrman, Sheryl, Milton, Donald K.

“…Little is known about the amount and infectiousness of influenza virus shed into exhaled breath. This contributes to uncertainty about the importance of…”
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Preclinical in vitro activity of QR-435 against influenza A virus as a virucide and in paper masks for prevention of viral transmission by Oxford, John S, Lambkin, Robert, Guralnik, Mario, Rosenbloom, Richard A, Petteruti, Michael P, Digian, Kelly, Lefante, Carolyn

“…Prophylaxis against influenza is difficult, and current approaches against pandemics may be ineffective because of shortages of the two proven classes of…”
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New Millennium Antivirals against Pandemic and Epidemic Influenza: The Neuraminidase Inhibitors by Oxford, John S, Novelli, Patricia, Sefton, Armine, Lambkin, Robert

“…The mushroom shaped outer spike protein of influenza, neuraminidase, was first discovered nearly 60 years ago. Its importance in viral replication was soon…”
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Viral Load Drives Disease in Humans Experimentally Infected with Respiratory Syncytial Virus by DEVINCENZO, John P, WILKINSON, Tom, OXFORD, John, PAREEK, Rajat, MOORE, Ryves, WALSH, Ed, STUDHOLME, Robert, DORSETT, Preston, ALVAREZ, Rene, LAMBKIN-WILLIAMS, Robert, VAISHNAW, Akshay, CEHELSKY, Jeff, MEYERS, Rachel, NOCHUR, Saraswathy, HARRISON, Lisa, MEEKING, Patricia, MANN, Alex, MOANE, Elizabeth

“…Respiratory syncytial virus (RSV) is the leading cause of childhood lower respiratory infection, yet viable therapies are lacking. Two major challenges have…”
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A plant‐produced influenza subunit vaccine protects ferrets against virus challenge by Mett, Vadim, Musiychuk, Konstantin, Bi, Hong, Farrance, Christine E., Horsey, April, Ugulava, Natalia, Shoji, Yoko, De La Rosa, Patricia, Palmer, Gene A., Rabindran, Shailaja, Streatfield, Stephen J., Boyers, Alison, Russell, Michael, Mann, Alex, Lambkin, Robert, Oxford, John S., Schild, Geoffrey C., Yusibov, Vidadi

“…Background  Influenza A viruses are of major concern for public health, causing worldwide epidemics associated with high morbidity and mortality. Vaccines are…”
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Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans by Zaas, Aimee K, Chen, Minhua, Varkey, Jay, Veldman, Timothy, Hero, 3rd, Alfred O, Lucas, Joseph, Huang, Yongsheng, Turner, Ronald, Gilbert, Anthony, Lambkin-Williams, Robert, Øien, N Christine, Nicholson, Bradly, Kingsmore, Stephen, Carin, Lawrence, Woods, Christopher W, Ginsburg, Geoffrey S

“…Acute respiratory infections (ARIs) are a common reason for seeking medical attention, and the threat of pandemic influenza will likely add to these numbers…”
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Human genetics and responses to influenza vaccination: clinical implications by Lambkin, Robert, Novelli, Patricia, Oxford, John, Gelder, Colin

“…Influenza A and B viruses are negative-strand RNA viruses that cause regular outbreaks of respiratory disease and substantially impact on morbidity and…”
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Would you volunteer to be quarantined and infected with influenza virus? by Oxford, John S, Gelder, Colin, Lambkin, Robert

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Minimal transmission in an influenza A by Nguyen-Van-Tam, Jonathan S, Killingley, Ben, Enstone, Joanne, Hewitt, Michael, Pantelic, Jovan, Grantham, Michael L, Bueno de Mesquita, P. Jacob, Lambkin-Williams, Robert, Gilbert, Anthony, Mann, Alexander, Forni, John, Noakes, Catherine J, Levine, Min Z, Berman, LaShondra, Lindstrom, Stephen, Cauchemez, Simon, Bischoff, Werner, Tellier, Raymond, Milton, Donald K, Fouchier, Ron A. M, Palese, Peter

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