Search Results - "Lambiase, Giulia"

High-throughput multiplex analysis of mAb aggregates and charge variants by automated two-dimensional size exclusion-cation exchange chromatography coupled to mass spectrometry by Lambiase, Giulia, Inman, Sophie E., Muroni, Maurizio, Lindo, Vivian, Dickman, Mark J., James, David C.

“…•2D SEC-CEX-MS allows multiplex analysis of mAb aggregates and charge variants in a single method.•2D SEC-CEX-MS streamlines product development in…”
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Development of a High-Throughput Analytical Platform for the Characterisation of Biopharmaceuticals Generated from Multi-Gene Engineered Cho Cells by Lambiase, Giulia

“…The biopharmaceuticals market was valued $325 billion in 2020 with revenues forecasted to rise in the upcoming decade. High-throughput process development…”
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An automated, low volume, and high-throughput analytical platform for aggregate quantitation from cell culture media by Lambiase, Giulia, Klottrup-Rees, Kerensa, Lovelady, Clare, Ali, Salma, Shepherd, Samuel, Muroni, Maurizio, Lindo, Vivian, James, David C., Dickman, Mark J.

“…•Developed an automated, small-scale analytical platform.•Analysis of protein biopharmaceuticals expressed in 96-DWP cell cultures.•Combines the purification…”
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Production of trimeric SARS‐CoV‐2 spike protein by CHO cells for serological COVID‐19 testing by Johari, Yusuf B., Jaffé, Stephen R. P., Scarrott, Joseph M., Johnson, Abayomi O., Mozzanino, Théo, Pohle, Thilo H., Maisuria, Sheetal, Bhayat‐Cammack, Amina, Lambiase, Giulia, Brown, Adam J., Tee, Kang Lan, Jackson, Philip J., Wong, Tuck Seng, Dickman, Mark J., Sargur, Ravishankar B., James, David C.

“…We describe scalable and cost‐efficient production of full length, His‐tagged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike glycoprotein…”
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Autophagy and intracellular product degradation genes identified by systems biology analysis reduce aggregation of bispecific antibody in CHO cells by Barzadd, Mona Moradi, Lundqvist, Magnus, Harris, Claire, Malm, Magdalena, Volk, Anna-Luisa, Thalén, Niklas, Chotteau, Veronique, Grassi, Luigi, Smith, Andrew, Abadi, Marina Leal, Lambiase, Giulia, Gibson, Suzanne, Hatton, Diane, Rockberg, Johan

“…Aggregation of therapeutic bispecific antibodies negatively affects the yield, shelf-life, efficacy and safety of these products. Pairs of stable Chinese…”
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