Search Results - "Lambeth, J D"

The Neutrophil NADPH Oxidase by Babior, B.M., Lambeth, J.D., Nauseef, W.

“…The NADPH oxidase of phagocytes catalyzes the conversion of oxygen to O−2. This multicomponent enzyme complex contains five essential protein components, two…”
Get full text

Cell transformation by the superoxide-generating oxidase Mox1 by Lambeth, J. David, Suh, Young-Ah, Arnold, Rebecca S, Lassegue, Bernard, Shi, Jing, Xu, Xiangxi, Sorescu, Dan, Chung, Andrew B, Griendling, Kathy K

“…Reactive oxygen species (ROS) generated in some non-phagocytic cells are implicated in mitogenic signalling and cancer. Many cancer cells show increased…”
Get full text

NOX enzymes and the biology of reactive oxygen by Lambeth, J. David

“…Professional phagocytes generate high levels of reactive oxygen species (ROS) using a superoxide-generating NADPH oxidase as part of their armoury of…”
Get full text

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein by BOWMAN, E. P, UHLINGER, D. J, LAMBETH, J. D

“…Phospholipase D in human neutrophil lysates is activated by GTP gamma S (guanosine 5'-O-(3-thiotriphosphate)), implying the participation of a GTP-binding…”
Get full text

Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1 by Alam, A, Leoni, G, Wentworth, C C, Kwal, J M, Wu, H, Ardita, C S, Swanson, P A, Lambeth, J D, Jones, R M, Nusrat, A, Neish, A S

“…The mammalian gut microbiota is essential for normal intestinal development, renewal, and repair. Injury to the intestinal mucosa can occur with infection,…”
Get full text

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2 by XU, X.-X, TAOLIN YI, BO TANG, LAMBETH, J. D

“…Disabled-2 (Dab2), a mammalian structural homolog of Drosophila Disabled (Dab), is a mitogen-responsive phosphoprotein. It has been speculated to be a negative…”
Get full text

Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2 by Lopez, I, Arnold, R S, Lambeth, J D

“…Phospholipase D (PLD) has been implicated in a variety of cellular processes including vesicular transport, the respiratory burst, and mitogenesis. PLD1, first…”
Get full text

Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol by OLSON, S. C, BOWMAN, E. P, LAMBETH, J. D

“…Receptor-linked activation of phospholipase D has been demonstrated recently in a variety of intact cell types including granulocytes, but little is known…”
Get full text

Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst by Wilson, E, Olcott, M C, Bell, R M, Merrill, A H, Lambeth, J D

“…The neutrophil oxidative burst is characterized by increased cellular O2 consumption due to the activation of a membrane-associated superoxide-generating…”
Get full text

NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) Domain by Cheng, Guangjie, Lambeth, J. David

“…NOXO1 (Nox organizing protein 1) and NOXA1 (Nox activating protein 1) are homologs of p47phox and p67phox. p47phox functions in phagocytes as an essential…”
Get full text

Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases by Lambeth, J David

“…Reactive oxygen species are classically described as occurring as an accidental byproduct of respiration, and are generally thought to be deleterious to…”
Get full text

Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5 by Cheng, G, Cao, Z, Xu, X, van Meir, E G, Lambeth, J D

“…gp91phox is the catalytic subunit of the respiratory burst oxidase, an NADPH-dependent, superoxide generating enzyme present in phagocytes. In phagocytes, the…”
Get full text

Participation of the small molecular weight GTP-binding protein Rac1 in cell-free activation and assembly of the respiratory burst oxidase. Inhibition by a carboxyl-terminal Rac peptide by KRECK, M. L, UHLINGER, D. J, SHIV RAJ TYAGI, INGE, K. L, LAMBETH, J. D

“…NADPH-dependent superoxide generation was activated by anionic amphiphiles plus GTP gamma S in a cell-free system consisting of plasma membranes plus…”
Get full text

Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways by Lassègue, B, Sorescu, D, Szöcs, K, Yin, Q, Akers, M, Zhang, Y, Grant, S L, Lambeth, J D, Griendling, K K

“…Emerging evidence indicates that reactive oxygen species are important regulators of vascular function. Although NAD(P)H oxidases have been implicated as major…”
Get full text

Characterization of the Flavoprotein Domain of gp91phox Which Has NADPH Diaphorase Activity by Han, Chang-Hoon, Nisimoto, Yukio, Lee, Sung-Haeng, Kim, Eugene T., Lambeth, J. David

“…A series of truncated forms of gp91phox were expressed in Escherichia coli in which the N-terminal hydrophobic transmembrane region was replaced with a portion…”
Get full text

Contrasting Roles of NADPH Oxidase Isoforms in Pressure-Overload Versus Angiotensin II–Induced Cardiac Hypertrophy by Byrne, Jonathan A, Grieve, David J, Bendall, Jennifer K, Li, Jian-Mei, Gove, Christopher, Lambeth, J David, Cave, Alison C, Shah, Ajay M

“…Increased production of reactive oxygen species (ROS) is implicated in the development of left ventricular hypertrophy (LVH). Phagocyte-type NADPH oxidases are…”
Get full text

A novel ecto-phosphatidic acid phosphohydrolase activity mediates activation of neutrophil superoxide generation by exogenous phosphatidic acid by Perry, D K, Stevens, V L, Widlanski, T S, Lambeth, J D

“…Phosphatidic acid (PA) added to intact cells activates a variety of processes including mitogenesis in fibroblasts and superoxide generation in neutrophils. We…”
Get full text

The respiratory burst oxidase of human neutrophils. Guanine nucleotides and arachidonate regulate the assembly of a multicomponent complex in a semirecombinant cell-free system by Uhlinger, D J, Tyagi, S R, Inge, K L, Lambeth, J D

“…We recently characterized a "semirecombinant" cell-free NADPH-oxidase system, comprised of plasma membrane plus the recombinant cytosolic proteins p47-phox and…”
Get full text

Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst by Tyagi, S R, Tamura, M, Burnham, D N, Lambeth, J D

“…Pretreatment (“priming”) of neutrophils with a non-activating concentration (2 nM) of phorbol myristate acetate (PMA) augments superoxide (O2-) production in…”
Get full text

Hydrogen Peroxide Mediates the Cell Growth and Transformation Caused by the Mitogenic Oxidase Nox1 by Arnold, Rebecca S., Shi, Jing, Murad, Emma, Whalen, Anne M., Sun, Carrie Q., Polavarapu, Rathnagiri, Parthasarathy, Sampath, Petros, John A., Lambeth, J. David

“…Nox1, a homologue of gp91phox, the catalytic moiety of the superoxide (O2-)-generating NADPH oxidase of phagocytes, causes increased O2- generation, increased…”
Get full text