Search Results - "Lambertus, Gordon R."

Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing by Frederick, Michael O, Boyse, Raymond A, Braden, Timothy M, Calvin, Joel R, Campbell, Bradley M, Changi, Shujauddin M, Coffin, Stephanie R, Condon, Carmel, Gowran, Olivia, McClary Groh, Jennifer, Groskreutz, Stephen R, Harms, Zachary D, Humenik, Ashley A, Kallman, Neil J, Klitzing, Nicholas D, Kopach, Michael E, Kretsinger, Juliana K, Lambertus, Gordon R, Lampert, Jeffrey T, Maguire, Laura M, Moynihan, Humphrey A, Mullane, Nessa S, Murphy, John D, O’Mahony, Marie E, Richey, Rachel N, Seibert, Kevin D, Spencer, Richard D, Strege, Mark A, Tandogan, Nil, Torres Torres, Frank L, Tsukanov, Sergey V, Xia, Han

“…The large-scale manufacture of complex synthetic peptides is challenging due to many factors such as manufacturing risk (including failed product…”
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Hydrogen Evolution from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Diboron Reagents: Process Safety and Hazard Considerations by Merritt, Jeremy M, Borkar, Indrakant, Buser, Jonas Y, Brewer, Alison Campbell, Campos, Odilon, Fleming, Jeffrey, Hansen, Caoimhe, Humenik, Ashley, Jeffery, Stephen, Kokitkar, Prashant B, Kolis, Stanley P, Forst, Mindy B, Lambertus, Gordon R, Martinelli, Joseph R, McCartan, Ciaran, Moursy, Hossam, Murphy, Donal, Murray, Michael M, O’Donnell, Kevin, O’Sullivan, Rita, Richardson, Gary A, Xia, Han

“…The hazard assessment of a telescoped Miyaura borylation and Suzuki coupling reaction employing bis­(pinacolato)­diboron (BisPin), used in the developmental…”
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Design and Comparison of Tubular and Pipes-in-Series Continuous Reactors for Direct Asymmetric Reductive Amination by Johnson, Martin D, May, Scott A, Haeberle, Brian, Lambertus, Gordon R, Pulley, Shon R, Stout, James R

“…A high pressure, high temperature direct asymmetric reductive amination (DARA) reaction was run in three different continuous reactor types; coiled tubes,…”
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Development and Manufacturing GMP Scale-Up of a Continuous Ir-Catalyzed Homogeneous Reductive Amination Reaction by May, Scott A, Johnson, Martin D, Buser, Jonas Y, Campbell, Alison N, Frank, Scott A, Haeberle, Brian D, Hoffman, Philip C, Lambertus, Gordon R, McFarland, Adam D, Moher, Eric D, White, Timothy D, Hurley, D. Declan, Corrigan, Aoife P, Gowran, Olivia, Kerrigan, Niall G, Kissane, Marie G, Lynch, Regina R, Sheehan, Paul, Spencer, Richard D, Pulley, Shon R, Stout, James R

“…The design, development, and scale up of a continuous iridium-catalyzed homogeneous high pressure reductive amination reaction to produce 6, the penultimate…”
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Continuous Liquid Vapor Reactions Part 1: Design and Characterization of a Reactor for Asymmetric Hydroformylation by Johnson, Martin D, May, Scott A, Calvin, Joel R, Lambertus, Gordon R, Kokitkar, Prashant B, Landis, Clark R, Jones, Bradley R, Abrams, M. Leigh, Stout, James R

“…A research scale continuous reactor system was designed and developed for high pressure asymmetric hydroformylation (AHF) reactions with an 8 h reaction time…”
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Development of Universal, Automated Sample Acquisition, Preparation, and Delivery Devices and Methods for Pharmaceutical Applications by Lambertus, Gordon R, Webster, Luke P, Braden, Timothy M, Campbell, Bradley M, McClary Groh, Jennifer, Maloney, Todd D, Milenbaugh, Paul, Spencer, Richard D, Sun, Wei-ming, Johnson, Martin D

“…Continued emphasis in the pharmaceutical industry toward development of hybrid and continuous processes has led to a resurgence in process analytical…”
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Silicon Microfabricated Column with Microfabricated Differential Mobility Spectrometer for GC Analysis of Volatile Organic Compounds by Lambertus, Gordon R, Fix, Cory S, Reidy, Shaelah M, Miller, Ranaan A, Wheeler, David, Nazarov, Erkinjon, Sacks, Richard

“…A 3.0-m-long, 150-μm-wide, 240-μm-deep channel etched in a 3.2-cm-square silicon chip, covered with a Pyrex wafer, and coated with a dimethyl polysiloxane…”
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Rapid determination of complex mixtures by dual-column gas chromatography with a novel stationary phase combination and spectrometric detection by Lambertus, Gordon R., Crank, Jeffrey A., McGuigan, Megan E., Kendler, Shai, Armstrong, Daniel W., Sacks, Richard D.

“…Fast GC separations of a broad range of analytes are demonstrated using a capillary column coated with a novel immobilized ionic liquid (IIL) stationary phase…”
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Ultrafast Gas Chromatographic Separation of Organophosphor and Organosulfur Compounds Utilizing a Microcountercurrent Flame Photometric Detector by Kendler, Shai, Reidy, Shaelah M, Lambertus, Gordon R, Sacks, Richard D

“…A microcountercurrent flame photometric detector (μcc-FPD) was adapted and optimized for ultrafast gas chromatographic (GC) separation and detection of…”
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Continuous GMP Manufacturing for Grignard Reagent/Zincate Synthesis and Negishi Coupling Reaction by Calvin, Joel R., Boyse, Raymond, Braden, Timothy M., Brewer, Alison C., Changi, Shujauddin, Harrold, Donal, Johnson, Martin, Kerr, Mark S., Lambertus, Gordon R., Luciani, Carla V., May, Scott A., Moloney, Harold, Murphy, John D., Roberts, Jeffrey C., Schafer, John P., Spencer, Richard D., Webster, Luke P.

“…A synthetic route to API was designed containing a Negishi cross-coupling reaction, where the zincate reagent was generated by transmetalation of a Grignard…”
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Fragmentation pathways and mechanisms of aromatic compounds in atmospheric pressure studied by GC–DMS and DMS–MS by Kendler, Shai, Lambertus, Gordon R., Dunietz, Barry D., Coy, Stephen L., Nazarov, Erkinjon G., Miller, Raanan A., Sacks, Richard D.

“…Differential mobility spectrometry (DMS) is a highly sensitive sensing technology capable of selecting and detecting ions based on the difference between ion…”
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A Micropump-Driven High-Speed MEMS Gas Chromatography System by Kim, Hanseup, Steinecker, William H., Reidy, Shaelah, Lambertus, Gordon R., Astle, Aaron A., Najafi, Khalil, Zellers, Edward T., Bernal, Luis P., Washabaugh, Peter D., Wise, Kensall D.

“…We report (1) the integration of the first functioning MEMS gas chromatography system ( μGC) featuring a micropump, a micro-column, and a micro-chemiresistor…”
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An Integrated Micro-Analytical System for Complex Vapor Mixtures by Zellers, E.T., Reidy, S., Veeneman, R.A., Gordenker, R., Steinecker, W.H., Lambertus, G.R., Hanseup Kim, Potkay, J.A., Rowe, M.P., Qiongyan Zhong, Avery, C., Chan, H.K.L., Sacks, R.D., Najafi, K., Wise, K.D.

“…A micro gas chromatograph (μGC) capable of quantitatively analyzing the components of complex vapor mixtures at trace concentrations is described. The μGC…”
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