Search Results - "Lambert, Nicole J."

RNA Sequence Context Effects Measured In Vitro Predict In Vivo Protein Binding and Regulation by Taliaferro, J. Matthew, Lambert, Nicole J., Sudmant, Peter H., Dominguez, Daniel, Merkin, Jason J., Alexis, Maria S., Bazile, Cassandra A., Burge, Christopher B.

“…Many RNA binding proteins (RBPs) bind specific RNA sequence motifs, but only a small fraction (∼15%–40%) of RBP motif occurrences are occupied in vivo. To…”
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Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins by Wang, Eric T, Ward, Amanda J, Cherone, Jennifer M, Giudice, Jimena, Wang, Thomas T, Treacy, Daniel J, Lambert, Nicole J, Freese, Peter, Saxena, Tanvi, Cooper, Thomas A, Burge, Christopher B

“…RNA binding proteins of the conserved CUGBP1, Elav-like factor (CELF) family contribute to heart and skeletal muscle development and are implicated in myotonic…”
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Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival by Conway, Anne E., Van Nostrand, Eric L., Pratt, Gabriel A., Aigner, Stefan, Wilbert, Melissa L., Sundararaman, Balaji, Freese, Peter, Lambert, Nicole J., Sathe, Shashank, Liang, Tiffany Y., Essex, Anthony, Landais, Severine, Burge, Christopher B., Jones, D. Leanne, Yeo, Gene W.

“…Human pluripotent stem cells (hPSCs) require precise control of post-transcriptional RNA networks to maintain proliferation and survival. Using enhanced UV…”
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Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses by Kapeli, Katannya, Pratt, Gabriel A., Vu, Anthony Q., Hutt, Kasey R., Martinez, Fernando J., Sundararaman, Balaji, Batra, Ranjan, Freese, Peter, Lambert, Nicole J., Huelga, Stephanie C., Chun, Seung J., Liang, Tiffany Y., Chang, Jeremy, Donohue, John P., Shiue, Lily, Zhang, Jiayu, Zhu, Haining, Cambi, Franca, Kasarskis, Edward, Hoon, Shawn, Ares Jr, Manuel, Burge, Christopher B., Ravits, John, Rigo, Frank, Yeo, Gene W.

“…The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare TAF15 function to that of two ALS-associated RBPs, FUS and…”
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Alternative splicing of RNA triplets is often regulated and accelerates proteome evolution by Bradley, Robert K, Merkin, Jason, Lambert, Nicole J, Burge, Christopher B

“…Thousands of human genes contain introns ending in NAGNAG (N any nucleotide), where both NAGs can function as 3' splice sites, yielding isoforms that differ by…”
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Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state by Katz, Yarden, Li, Feifei, Lambert, Nicole J, Sokol, Ethan S, Tam, Wai-Leong, Cheng, Albert W, Airoldi, Edoardo M, Lengner, Christopher J, Gupta, Piyush B, Yu, Zhengquan, Jaenisch, Rudolf, Burge, Christopher B

“…The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated cells,…”
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The conformation of microRNA seed regions in native microRNPs is prearranged for presentation to mRNA targets by Lambert, Nicole J., Gu, Sam G., Zahler, Alan M.

“…MicroRNAs control gene expression by post-transcriptional down-regulation of their target mRNAs. Complementarity between the seed region (nucleotides 2-8) of a…”
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Global analysis of alternative splicing uncovers developmental regulation of nonsense-mediated decay in C. elegans by Barberan-Soler, Sergio, Lambert, Nicole J, Zahler, Alan M

“…Alternative splicing coupled to nonsense-mediated decay (AS-NMD) is a mechanism for post-transcriptional regulation of gene expression. We analyzed the global…”
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The sarcin-ricin loop of 23S rRNA is essential for assembly of the functional core of the 50S ribosomal subunit by Lancaster, Laura, Lambert, Nicole J, Maklan, Eric J, Horan, Lucas H, Noller, Harry F

“…The sarcin-ricin loop (SRL) of 23S rRNA in the large ribosomal subunit is a factor-binding site that is essential for GTP-catalyzed steps in translation, but…”
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Sequence, Structure, and Context Preferences of Human RNA Binding Proteins by Dominguez, Daniel, Freese, Peter, Alexis, Maria S., Su, Amanda, Hochman, Myles, Palden, Tsultrim, Bazile, Cassandra, Lambert, Nicole J., Van Nostrand, Eric L., Pratt, Gabriel A., Yeo, Gene W., Graveley, Brenton R., Burge, Christopher B.

“…RNA binding proteins (RBPs) orchestrate the production, processing, and function of mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an…”
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A large-scale binding and functional map of human RNA-binding proteins by Van Nostrand, Eric L., Freese, Peter, Pratt, Gabriel A., Wang, Xiaofeng, Wei, Xintao, Xiao, Rui, Blue, Steven M., Chen, Jia-Yu, Cody, Neal A. L., Dominguez, Daniel, Olson, Sara, Sundararaman, Balaji, Zhan, Lijun, Bazile, Cassandra, Bouvrette, Louis Philip Benoit, Bergalet, Julie, Duff, Michael O., Garcia, Keri E., Gelboin-Burkhart, Chelsea, Hochman, Myles, Lambert, Nicole J., Li, Hairi, McGurk, Michael P., Nguyen, Thai B., Palden, Tsultrim, Rabano, Ines, Sathe, Shashank, Stanton, Rebecca, Su, Amanda, Wang, Ruth, Yee, Brian A., Zhou, Bing, Louie, Ashley L., Aigner, Stefan, Fu, Xiang-Dong, Lécuyer, Eric, Burge, Christopher B., Graveley, Brenton R., Yeo, Gene W.

“…Many proteins regulate the expression of genes by binding to specific regions encoded in the genome 1 . Here we introduce a new data set of RNA elements in the…”
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RNA Bind-n-Seq: Measuring the Binding Affinity Landscape of RNA-Binding Proteins by Lambert, Nicole J, Robertson, Alex D, Burge, Christopher B

“…RNA-binding proteins (RBPs) coordinate post-transcriptional control of gene expression, often through sequence-specific recognition of primary transcripts or…”
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Early Assessment of Molecular Progression and Response by Whole-genome Circulating Tumor DNA in Advanced Solid Tumors by Davis, Andrew A, Iams, Wade T, Chan, David, Oh, Michael S, Lentz, Robert W, Peterman, Neil, Robertson, Alex, Shah, Abhik, Srivas, Rohith, Wilson, Timothy J, Lambert, Nicole J, George, Peter S, Wong, Becky, Wood, Haleigh W, Close, Jason C, Tezcan, Ayse, Nesmith, Ken, Tezcan, Haluk, Chae, Young Kwang

“…Treatment response assessment for patients with advanced solid tumors is complex and existing methods require greater precision. Current guidelines rely on…”
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Author Correction: A large-scale binding and functional map of human RNA-binding proteins by Van Nostrand, Eric L., Freese, Peter, Pratt, Gabriel A., Wang, Xiaofeng, Wei, Xintao, Xiao, Rui, Blue, Steven M., Chen, Jia-Yu, Cody, Neal A. L., Dominguez, Daniel, Olson, Sara, Sundararaman, Balaji, Zhan, Lijun, Bazile, Cassandra, Bouvrette, Louis Philip Benoit, Bergalet, Julie, Duff, Michael O., Garcia, Keri E., Gelboin-Burkhart, Chelsea, Hochman, Myles, Lambert, Nicole J., Li, Hairi, McGurk, Michael P., Nguyen, Thai B., Palden, Tsultrim, Rabano, Ines, Sathe, Shashank, Stanton, Rebecca, Su, Amanda, Wang, Ruth, Yee, Brian A., Zhou, Bing, Louie, Ashley L., Aigner, Stefan, Fu, Xiang-Dong, Lécuyer, Eric, Burge, Christopher B., Graveley, Brenton R., Yeo, Gene W.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-03067-w…”
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Mechanism of messenger RNA target recognition by microRNAs by Lambert, Nicole J

“…MicroRNAs control gene expression by post-transcriptional down-regulation of their target mRNAs. Complementarity between the seed region (nucleotides 2-8) of a…”
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