Search Results - "Lambás Señas, Laura"
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Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania
Published in The international journal of neuropsychopharmacology (01-01-2015)“…Recent studies revealed that bipolar disorder may be associated with deficits of neuroplasticity. Additionally, accumulating evidence has implicated…”
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Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats
Published in Progress in neuro-psychopharmacology & biological psychiatry (03-06-2013)“…The neurobiological mechanisms underlying the pathophysiology and therapeutics of bipolar disorder are still unknown. In recent years, protein kinase C (PKC)…”
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A Role for the PKC Signaling System in the Pathophysiology and Treatment of Mood Disorders: Involvement of a Functional Imbalance?
Published in Molecular neurobiology (01-12-2011)“…Mood disorders, such as bipolar and major depressive disorders, are frequent, severe, and often disabling neuropsychiatric diseases affecting millions of…”
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Astrocytes and gliotransmitters: new players in the treatment of major depression?
Published in Current drug targets (01-10-2013)“…With a lifetime prevalence of more than 16% worldwide, major depressive disorder is one of the most common psychiatric disorders. Only one third of patients…”
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Highly sensitive assay for the measurement of serotonin in microdialysates using capillary high-performance liquid chromatography with electrochemical detection
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01-05-2007)“…A highly sensitive isocratic capillary high-performance liquid chromatographic (HPLC) method with electrochemical detection (ED) for the simultaneous…”
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In vivo effects of pardoprunox (SLV308), a partial D2/D3 receptor and 5-HT1A receptor agonist, on rat dopamine and serotonin neuronal activity
Published in Synapse (New York, N.Y.) (01-10-2011)“…The nonergot ligand pardoprunox (SLV308) is a dopamine (DA) D2/D3 and serotonin (5‐HT)1A receptor agonist and a new candidate for the treatment of Parkinson's…”
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Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy
Published in Neuropsychopharmacology (01-05-2011)“…Current antidepressants still display unsatisfactory efficacy and a delayed onset of therapeutic action. Here we show that the pharmacological blockade of…”
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Functional correlates for 5-HT1A receptors in maternally deprived rats displaying anxiety and depression-like behaviors
Published in Progress in neuro-psychopharmacology & biological psychiatry (17-03-2009)“…Maternal separation is known to induce long-term changes in neuroendocrine and emotional responsiveness to stress in a large variety of models. We examined an…”
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In vivo effects of pardoprunox (SLV308), a partial D 2 /D 3 receptor and 5‐HT 1A receptor agonist, on rat dopamine and serotonin neuronal activity
Published in Synapse (New York, N.Y.) (01-10-2011)“…The nonergot ligand pardoprunox (SLV308) is a dopamine (DA) D 2 /D 3 and serotonin (5‐HT) 1A receptor agonist and a new candidate for the treatment of…”
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Endogenous Neurotensin in the Ventral Tegmental Area Contributes to Amphetamine Behavioral Sensitization
Published in Neuropsychopharmacology (New York, N.Y.) (01-05-2005)“…Studies showing psychostimulant-like effects of exogenous neurotensin (NT) infused into the ventral tegmental area (VTA) prompted us to examine the role in the…”
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R-citalopram prevents the neuronal adaptive changes induced by escitalopram
Published in Neuroreport (08-10-2007)“…This study examined the long-term effects of the antidepressant escitalopram on rat serotonin (5-HT) neuronal activity and hippocampal neuroplasticity. In the…”
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Changes in Proenkephalin mRNA expression in forebrain areas after amphetamine-induced behavioural sensitization
Published in Pharmacology, biochemistry and behavior (01-06-2007)“…Acute and repeated psychostimulant administration induces a long-lasting enhanced behavioural response to a subsequent drug challenge, known as behavioural…”
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Blockade of β-adrenergic receptors prevents amphetamine-induced behavioural sensitization in rats: a putative role of the bed nucleus of the stria terminalis
Published in The international journal of neuropsychopharmacology (01-12-2005)“…Recent findings have given evidence a role for noradrenergic transmission in the mechanisms underlying behavioural sensitization to psychostimulants. This work…”
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Chronic Blockade of Neurotensin Receptors Strongly Reduces Sensitized, but Not Acute, Behavioral Response to D-amphetamine
Published in Neuropsychopharmacology (New York, N.Y.) (01-01-2002)“…This study investigated the effect of a chronic blockade of neurotensin (NT) receptors on the sensitized behavioral response to amphetamine using a nonpeptide…”
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Microdialysis monitoring of catecholamines and excitatory amino acids in the rat and mouse brain: recent developments based on capillary electrophoresis with laser-induced fluorescence detection--a mini-review
Published in Cellular and molecular neurobiology (01-10-2003)“…1. Although microdialysis is a widely used approach for in vivo monitoring extracellular neurotransmitter concentrations, it has been previously limited in…”
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In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity
Published in European journal of pharmacology (10-01-2003)“…The aim of the present study was to compare, in chloral-hydrate anaesthetized rats, the alpha(2)-adrenergic properties of the selective 5-HT(1A) receptor…”
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NO synthase inhibitors attenuate locus coeruleus catecholamine metabolism and behavior induced by morphine withdrawal
Published in Neuroreport (16-04-2002)“…The effects of nitric oxide synthase (NOS) inhibitors were examined simultaneously on the behavior and on the catecholaminergic metabolism in the locus…”
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Therapeutic potential of 5-HT7 receptors in mood disorders
Published in Current drug targets (01-11-2009)“…Serotonin (5-HT) exerts its diverse physiological and pharmacological effects through the activation of multiple receptor subtypes. One of the newest members…”
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5-HT7 receptor antagonists as a new class of antidepressants
Published in Drug news & perspectives (01-12-2007)“…It is now admitted that major depression is associated with monoaminergic dysfunctions as well as with functional brain plasticity impairments. Despite the…”
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