Search Results - "Lamb, Patricia W."

Loss of GABA co-transmission from cholinergic neurons impairs behaviors related to hippocampal, striatal, and medial prefrontal cortex functions by Goral, R Oliver, Harper, Kathryn M, Bernstein, Briana J, Fry, Sydney A, Lamb, Patricia W, Moy, Sheryl S, Cushman, Jesse D, Yakel, Jerrel L

“…Altered signaling or function of acetylcholine (ACh) has been reported in various neurological diseases, including Alzheimer's disease, Tourette syndrome,…”
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Research tool: validation of floxed α7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches by Hernandez, Caterina M., Cortez, Ibdanelo, Gu, Zhenglin, Colón‐Sáez, José O., Lamb, Patricia W., Wakamiya, Maki, Yakel, Jerrel L., Dineley, Kelly T.

“…Key points Currently, no animal model exists in which selective deletion of α7 nAChRs from a specific cell type or tissue is possible through genetic…”
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Characterization of a Nicotine-Sensitive Neuronal Population in Rat Entorhinal Cortex by Tu, Bin, Gu, Zhenglin, Shen, Jian-xin, Lamb, Patricia W, Yakel, Jerrel L

“…The entorhinal cortex (EC) is a part of the hippocampal complex that is essential to learning and memory, and nicotine affects memory by activating nicotinic…”
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Rat nicotinic ACh receptor α7 and β2 subunits co‐assemble to form functional heteromeric nicotinic receptor channels by Khiroug, Serguei S., Harkness, Patricia C., Lamb, Patricia W., Sudweeks, Sterling N., Khiroug, Leonard, Millar, Neil S., Yakel, Jerrel L.

“…Rat hippocampal interneurons express diverse subtypes of functional nicotinic acetylcholine receptors (nAChRs), including α7‐containing receptors that have…”
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Cholinergic coordination of presynaptic and postsynaptic activity induces timing-dependent hippocampal synaptic plasticity by Gu, Zhenglin, Lamb, Patricia W, Yakel, Jerrel L

“…Correlated presynaptic and postsynaptic activity is the key factor in inducing Hebbian plasticity and memory. However, little is known about the physiological…”
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Acetylcholine Neurons Become Cholinergic during Three Time Windows in the Developing Mouse Brain by Oliver Goral, Rene, Lamb, Patricia W, Yakel, Jerrel L

“…Acetylcholine (ACh) neurons in the central nervous system are required for the coordination of neural network activity during higher brain functions, such as…”
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Research tool: validation of floxed alpha 7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches by Hernandez, Caterina M, Cortez, Ibdanelo, Gu, Zhenglin, Colon-Saez, Jose O, Lamb, Patricia W, Wakamiya, Maki, Yakel, Jerrel L, Dineley, Kelly T

“…Currently, no animal model exists in which selective deletion of alpha 7 nAChRs from a specific cell type or tissue is possible through genetic manipulation.We…”
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Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β‐sheet by McCormack, Thomas J., Melis, Claudio, Colón, José, Gay, Elaine A., Mike, Arpad, Karoly, Robert, Lamb, Patricia W., Molteni, Carla, Yakel, Jerrel L.

“…The rat α7 nicotinic acetylcholine receptor (nAChR) has a proline residue near the middle of the β9 strand. The replacement of this proline residue at position…”
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Identification and Functional Characterization of a Novel Acetylcholine-Binding Protein from the Marine Annelid Capitella teleta by McCormack, Thomas, Petrovich, Robert M, Mercier, Kelly A, DeRose, Eugene F, Cuneo, Matthew J, Williams, Jason, Johnson, Katina L, Lamb, Patricia W, London, Robert E, Yakel, Jerrel L

“…We identified a homologue of the molluscan acetylcholine-binding protein (AChBP) in the marine polychaete Capitella teleta, from the annelid phylum. The amino…”
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Induction of Gene Amplification by Arsenic by Lee, Te-Chang, Tanaka, Noriho, Lamb, Patricia W., Gilmer, Tona M., Barrett, J. Carl

“…Arsenic is a well-established carcinogen in humans, but there is little evidence for its carcinogenicity in animals and it is inactive as an initiator or tumor…”
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15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer by Nixon, Jennifer B., Kim, Kyung-Su, Lamb, Patricia W., Bottone, Frank G., Eling, Thomas E.

“…The localization of 15-lipoxygenase-1 (15-LO-1) in human colorectal carcinoma and normal adjacent tissue was examined using immunohistochemistry. In normal…”
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Inhibition of neuronal nicotinic acetylcholine receptor channels expressed in Xenopus oocytes by beta-amyloid1-42 peptide by Lamb, Patricia W, Melton, Mark A, Yakel, Jerrel L

“…Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in a variety of physiological processes, including cognition and development. Dysfunctions in…”
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Multiple Mechanisms for the Carcinogenic Effects of Asbestos and Other Mineral Fibers by Barrett, J. Carl, Lamb, Patricia W., Wiseman, Roger W.

“…Asbestos and other mineral fibers are carcinogenic to humans and animals but differ from many carcinogens in that they do not induce gene mutations. An…”
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Research tool: validation of floxed [alpha]7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches by Hernandez, Caterina M, Cortez, Ibdanelo, Gu, Zhenglin, Colon-Saez, José O, Lamb, Patricia W, Wakamiya, Maki, Yakel, Jerrel L, Dineley, Kelly T

“…Key points Currently, no animal model exists in which selective deletion of [alpha]7 nAChRs from a specific cell type or tissue is possible through genetic…”
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Mechanisms of arsenic-induced cell transformation by Barrett, J C, Lamb, P W, Wang, T C, Lee, T C

“…Arsenic is a well-established carcinogen in humans, but there is little evidence for its carcinogenicity in animals and it is inactive as an initiator or tumor…”
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Role of chromosome loss in ras/myc-induced Syrian hamster tumors by OSHIMURA, M, KOI, M, OZAWA, N, SUGAWARA, O, LAMB, P. W, BARRETT, J. C

“…It has been shown previously that normal Syrian hamster embryo cells are neoplastically transformed by transfection with two cooperating oncogenes, v-myc plus…”
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Rapid desensitization of the rat [alpha]7 nAChR is facilitated by the presence of a proline residue in the outer [beta]-sheet by McCormack, Thomas J, Melis, Claudio, Colon, José, Gay, Elaine A, Mike, Arpad, Karoly, Robert, Lamb, Patricia W, Molteni, Carla, Yakel, Jerrel L

“…The rat [alpha]7 nicotinic acetylcholine receptor (nAChR) has a proline residue near the middle of the [beta]9 strand. The replacement of this proline residue…”
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Structural determinates for apolipoprotein E-derived peptide interaction with the alpha7 nicotinic acetylcholine receptor by Gay, Elaine A, Bienstock, Rachelle J, Lamb, Patricia W, Yakel, Jerrel L

“…Neuronal nicotinic acetylcholine receptor (nAChR) signaling has been implicated in a variety of normal central nervous system (CNS) functions as well as an…”
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Involvement of carrot cell surface proteins in attachment of Agrobacterium tumefaciens by Gurlitz, R.H.G, Lamb, P.W, Matthysse, A.G

“…The initial step in tumor formation by Agrobacterium tumefaciens is the site-specific attachment of the bacteria to plant cells. A similar attachment to plant…”
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Inhibition of neuronal nicotinic acetylcholine receptor channels expressed in Xenopus oocytes by [beta]-amyloid1-42 peptide by Lamb, Patricia W, Melton, Mark A, Yakel, Jerrel L

“…Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in a variety of physiological processes, including cognition and development. Dysfunctions in…”
Get full text