Search Results - "Lamb, Jeffrey P"

Discovery of molecular switches within the ADX-47273 mGlu₅ PAM scaffold that modulate modes of pharmacology to afford potent mGlu₅ NAMs, PAMs and partial antagonists by Lamb, Jeffrey P, Engers, Darren W, Niswender, Colleen M, Rodriguez, Alice L, Venable, Daryl F, Conn, P. Jeffrey, Lindsley, Craig W

“…This Letter describes a chemical lead optimization campaign directed at a weak mGlu₅ NAM discovered while developing SAR for the mGlu₅ PAM, ADX-47273. An…”
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Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound by Mueller, Ralf, Dawson, Eric S, Meiler, Jens, Rodriguez, Alice L, Chauder, Brian A, Bates, Brittney S, Felts, Andrew S, Lamb, Jeffrey P, Menon, Usha N, Jadhav, Sataywan B, Kane, Alexander S, Jones, Carrie K, Gregory, Karen J, Niswender, Colleen M, Conn, P. Jeffrey, Olsen, Christopher M, Winder, Danny G, Emmitte, Kyle A, Lindsley, Craig W

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Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound by Mueller, Ralf, Dawson, Eric S., Meiler, Jens, Rodriguez, Alice L., Chauder, Brian A., Bates, Brittney S., Felts, Andrew S., Lamb, Jeffrey P., Menon, Usha N., Jadhav, Sataywan B., Kane, Alexander S., Jones, Carrie K., Gregory, Karen J., Niswender, Colleen M., Conn, P. Jeffrey, Olsen, Christopher M., Winder, Danny G., Emmitte, Kyle A., Lindsley, Craig W.

“…From ANNs to NAMs! Data from an experimental metabotropic glutamate receptor 5 (mGlu5) high‐throughput screen (HTS) were employed to train artificial neural…”
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3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats by Felts, Andrew S, Lindsley, Stacey R, Lamb, Jeffrey P, Rodriguez, Alice L, Menon, Usha N, Jadhav, Satyawan, Jones, Carrie K, Conn, P Jeffrey, Lindsley, Craig W, Emmitte, Kyle A

“…Development of SAR in a 3-cyano-5-fluoro-N-arylbenzamide series of non-competitive antagonists of mGlu(5) using a functional cell-based assay is described in…”
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3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu5: Identification of easily prepared tool compounds with CNS exposure in rats by Felts, Andrew S., Lindsley, Stacey R., Lamb, Jeffrey P., Rodriguez, Alice L., Menon, Usha N., Jadhav, Satyawan, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.

“…Development of SAR in a 3-cyano-5-fluoro-N-arylbenzamide series of non-competitive antagonists of mGlu5 using a functional cell-based assay is described in…”
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Discovery of molecular switches within the ADX-47273 mGlu sub(5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu) sub(5) NAMs, PAMs and partial antagonists by Lamb, Jeffrey P, Engers, Darren W, Niswender, Colleen M, Rodriguez, Alice L, Venable, Daryl F, Conn, Jeffrey P, Lindsley, Craig W

“…This Letter describes a chemical lead optimization campaign directed at a weak mGlu sub(5 NAM discovered while developing SAR for the mGlu) sub(5) PAM,…”
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Discovery of molecular switches within the ADX-47273 mGlu 5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu 5 NAMs, PAMs and partial antagonists by Lamb, Jeffrey P., Engers, Darren W., Niswender, Colleen M., Rodriguez, Alice L., Venable, Daryl F., Conn, Jeffrey P., Lindsley, Craig W.

“…This Letter describes a chemical lead optimization campaign directed at a weak mGlu 5 NAM discovered while developing SAR for the mGlu 5 PAM, ADX-47273. An…”
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3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu sub(5): Identification of easily prepared tool compounds with CNS exposure in rats by Felts, Andrew S, Lindsley, Stacey R, Lamb, Jeffrey P, Rodriguez, Alice L, Menon, Usha N, Jadhav, Satyawan, Jones, Carrie K, Conn, PJeffrey, Lindsley, Craig W, Emmitte, Kyle A

“…Development of SAR in a 3-cyano-5-fluoro-N-arylbenzamide series of non-competitive antagonists of mGlu sub(5) using a functional cell-based assay is described…”
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Discovery of (2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine mGlu5 NAMs: From Artificial Neural Network Virtual Screen to in vivo Tool Compound by Mueller, Ralf, Dawson, Eric S., Meiler, Jens, Rodriguez, Alice L., Chauder, Brian A., Bates, Brittney S., Felts, Andrew S., Lamb, Jeffrey P., Menon, Usha N., Jadhav, Sataywan B., Kane, Alexander S., Jones, Carrie K., Gregory, Karen J., Niswender, Colleen M., Conn, P. Jeffrey, Olsen, Christopher M., Winder, Danny G., Emmitte, Kyle A., Lindsley, Craig W.

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