Search Results - "Lamb, Don C."

A self-assembled nanoscale robotic arm controlled by electric fields by Kopperger, Enzo, List, Jonathan, Madhira, Sushi, Rothfischer, Florian, Lamb, Don C, Simmel, Friedrich C

“…The use of dynamic, self-assembled DNA nanostructures in the context of nanorobotics requires fast and reliable actuation mechanisms. We therefore created a…”
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PAM: A Framework for Integrated Analysis of Imaging, Single-Molecule, and Ensemble Fluorescence Data by Schrimpf, Waldemar, Barth, Anders, Hendrix, Jelle, Lamb, Don C.

“…Fluorescence microscopy and spectroscopy data hold a wealth of information on the investigated molecules, structures, or organisms. Nowadays, the same…”
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Single-Virus Tracking: From Imaging Methodologies to Virological Applications by Liu, Shu-Lin, Wang, Zhi-Gang, Xie, Hai-Yan, Liu, An-An, Lamb, Don C, Pang, Dai-Wen

“…Uncovering the mechanisms of virus infection and assembly is crucial for preventing the spread of viruses and treating viral disease. The technique of…”
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Chemical diversity in a metal–organic framework revealed by fluorescence lifetime imaging by Schrimpf, Waldemar, Jiang, Juncong, Ji, Zhe, Hirschle, Patrick, Lamb, Don C., Yaghi, Omar M., Wuttke, Stefan

“…The presence and variation of chemical functionality and defects in crystalline materials, such as metal–organic frameworks (MOFs), have tremendous impact on…”
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Arbitrary-Region Raster Image Correlation Spectroscopy by Hendrix, Jelle, Dekens, Tomas, Schrimpf, Waldemar, Lamb, Don C.

“…Combining imaging with correlation spectroscopy, as in raster image correlation spectroscopy (RICS), makes it possible to extract molecular translational…”
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Folding pathway of a discontinuous two-domain protein by Agam, Ganesh, Barth, Anders, Lamb, Don C.

“…It is estimated that two-thirds of all proteins in higher organisms are composed of multiple domains, many of them containing discontinuous folds. However, to…”
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Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study by Hellenkamp, Björn, Schmid, Sonja, Doroshenko, Olga, Opanasyuk, Oleg, Kühnemuth, Ralf, Rezaei Adariani, Soheila, Ambrose, Benjamin, Aznauryan, Mikayel, Barth, Anders, Birkedal, Victoria, Bowen, Mark E., Chen, Hongtao, Cordes, Thorben, Eilert, Tobias, Fijen, Carel, Gebhardt, Christian, Götz, Markus, Gouridis, Giorgos, Gratton, Enrico, Ha, Taekjip, Hao, Pengyu, Hanke, Christian A., Hartmann, Andreas, Hendrix, Jelle, Hildebrandt, Lasse L., Hirschfeld, Verena, Hohlbein, Johannes, Hua, Boyang, Hübner, Christian G., Kallis, Eleni, Kapanidis, Achillefs N., Kim, Jae-Yeol, Krainer, Georg, Lamb, Don C., Lee, Nam Ki, Lemke, Edward A., Levesque, Brié, Levitus, Marcia, McCann, James J., Naredi-Rainer, Nikolaus, Nettels, Daniel, Ngo, Thuy, Qiu, Ruoyi, Robb, Nicole C., Röcker, Carlheinz, Sanabria, Hugo, Schlierf, Michael, Schröder, Tim, Schuler, Benjamin, Seidel, Henning, Streit, Lisa, Thurn, Johann, Tinnefeld, Philip, Tyagi, Swati, Vandenberk, Niels, Vera, Andrés Manuel, Weninger, Keith R., Wünsch, Bettina, Yanez-Orozco, Inna S., Michaelis, Jens, Seidel, Claus A. M., Craggs, Timothy D., Hugel, Thorsten

“…Single-molecule Förster resonance energy transfer (smFRET) is increasingly being used to determine distances, structures, and dynamics of biomolecules in vitro…”
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Coordinated Conformational Processing of the Tumor Suppressor Protein p53 by the Hsp70 and Hsp90 Chaperone Machineries by Dahiya, Vinay, Agam, Ganesh, Lawatscheck, Jannis, Rutz, Daniel Andreas, Lamb, Don C., Buchner, Johannes

“…p53, the guardian of the genome, requires chaperoning by Hsp70 and Hsp90. However, how the two chaperone machineries affect p53 conformation and regulate its…”
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Single-particle Tracking as a Quantitative Microscopy-based Approach to Unravel Cell Entry Mechanisms of Viruses and Pharmaceutical Nanoparticles by Ruthardt, Nadia, Lamb, Don C, Bräuchle, Christoph

“…Highly sensitive fluorescence microscopy techniques allow single nanoparticles to be tracked during their uptake into living cells with high temporal and…”
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Directional Photonic Wire Mediated by Homo-Förster Resonance Energy Transfer on a DNA Origami Platform by Nicoli, Francesca, Barth, Anders, Bae, Wooli, Neukirchinger, Fabian, Crevenna, Alvaro H, Lamb, Don C, Liedl, Tim

“…Elaborating efficient strategies and deepening the understanding of light transport at the nanoscale is of great importance for future designs of artificial…”
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Deep-LASI: deep-learning assisted, single-molecule imaging analysis of multi-color DNA origami structures by Wanninger, Simon, Asadiatouei, Pooyeh, Bohlen, Johann, Salem, Clemens-Bässem, Tinnefeld, Philip, Ploetz, Evelyn, Lamb, Don C.

“…Single-molecule experiments have changed the way we explore the physical world, yet data analysis remains time-consuming and prone to human bias. Here, we…”
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Factors Affecting the Quantification of Biomolecular Interactions by Fluorescence Cross-Correlation Spectroscopy by Foo, Yong Hwee, Naredi-Rainer, Nikolaus, Lamb, Don C., Ahmed, Sohail, Wohland, Thorsten

“…Fluorescence cross-correlation spectroscopy (FCCS) is used to determine interactions and dissociation constants (Kds) of biomolecules. The determination of a…”
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Protein-mediated RNA folding governs sequence-specific interactions between rotavirus genome segments by Borodavka, Alexander, Dykeman, Eric C, Schrimpf, Waldemar, Lamb, Don C

“…Segmented RNA viruses are ubiquitous pathogens, which include influenza viruses and rotaviruses. A major challenge in understanding their assembly is the…”
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Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions by Lamb, Don C, Buchner, Johannes, Marcinowski, Moritz, Höller, Matthias, Feige, Matthias J, Baerend, Danae

“…BiP is an Hsp70 chaperone in the endoplasmic reticulum (ER) and is crucial for protein folding and quality control. Using single-molecule and ensemble FRET,…”
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Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers by Hendrix, Jelle, Baumgärtel, Viola, Schrimpf, Waldemar, Ivanchenko, Sergey, Digman, Michelle A, Gratton, Enrico, Kräusslich, Hans-Georg, Müller, Barbara, Lamb, Don C

“…Assembly of the Gag polyprotein into new viral particles in infected cells is a crucial step in the retroviral replication cycle. Currently, little is known…”
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Density fluctuations as door-opener for diffusion on crowded surfaces by Henß, Ann-Kathrin, Sakong, Sung, Messer, Philipp K, Wiechers, Joachim, Schuster, Rolf, Lamb, Don C, Groß, Axel, Wintterlin, Joost

“…How particles can move on a catalyst surface that, under the conditions of an industrial process, is highly covered by adsorbates and where most adsorption…”
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Recognition of the 3′ splice site RNA by the U2AF heterodimer involves a dynamic population shift by von Voithenberg, Lena Voith, Sánchez-Rico, Carolina, Kang, Hyun-Seo, Madl, Tobias, Zanier, Katia, Barth, Anders, Warner, Lisa R., Sattler, Michael, Lamb, Don C.

“…An essential early step in the assembly of human spliceosomes onto pre-mRNA involves the recognition of regulatory RNA cis elements in the 3′ splice site by…”
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Evolution of the conformational dynamics of the molecular chaperone Hsp90 by Riedl, Stefan, Bilgen, Ecenaz, Agam, Ganesh, Hirvonen, Viivi, Jussupow, Alexander, Tippl, Franziska, Riedl, Maximilian, Maier, Andreas, Becker, Christian F. W., Kaila, Ville R. I., Lamb, Don C., Buchner, Johannes

“…Hsp90 is a molecular chaperone of central importance for protein homeostasis in the cytosol of eukaryotic cells, with key functional and structural traits…”
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Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals by Mulholland, Christopher B., Nishiyama, Atsuya, Ryan, Joel, Nakamura, Ryohei, Yiğit, Merve, Glück, Ivo M., Trummer, Carina, Qin, Weihua, Bartoschek, Michael D., Traube, Franziska R., Parsa, Edris, Ugur, Enes, Modic, Miha, Acharya, Aishwarya, Stolz, Paul, Ziegenhain, Christoph, Wierer, Michael, Enard, Wolfgang, Carell, Thomas, Lamb, Don C., Takeda, Hiroyuki, Nakanishi, Makoto, Bultmann, Sebastian, Leonhardt, Heinrich

“…Genome-wide DNA demethylation is a unique feature of mammalian development and naïve pluripotent stem cells. Here, we describe a recently evolved pathway in…”
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3D motion of vesicles along microtubules helps them to circumvent obstacles in cells by Verdeny-Vilanova, Ione, Wehnekamp, Fabian, Mohan, Nitin, Sandoval Álvarez, Ángel, Borbely, Joseph Steven, Otterstrom, Jason John, Lamb, Don C, Lakadamyali, Melike

“…Vesicle transport is regulated at multiple levels, including regulation by scaffolding proteins and the cytoskeleton. This tight regulation is essential, since…”
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