Search Results - "Lam, Wing W"

Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction by Bauman, Jonathon N, Kelly, Joan M, Tripathy, Sakambari, Zhao, Sabrina X, Lam, Wing W, Kalgutkar, Amit S, Obach, R. Scott

“…In vitro covalent binding studies in which xenobiotics are shown to undergo metabolism-dependent covalent binding to macromolecules have been commonly used to…”
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Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α‑Fluorination by Huang, Hui, Meegalla, Sanath K, Lanter, James C, Winters, Michael P, Zhao, Shuyuan, Littrell, James, Qi, Jenson, Rady, Brian, Lee, Paul S, Liu, Jianying, Martin, Tonya, Lam, Wing W, Xu, Fran, Lim, Heng Keang, Wilde, Thomas, Silva, Jose, Otieno, Monicah, Pocai, Alessandro, Player, Mark R

“…GPR40 is a G-protein-coupled receptor which mediates fatty acid-induced glucose-stimulated insulin secretion from pancreatic beta cells and incretion release…”
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Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists by Milbank, Jared B.J., Knauer, Christopher S., Augelli-Szafran, Corinne E., Sakkab-Tan, Annette T., Lin, Kristin K., Yamagata, Koji, Hoffman, Jennifer K., Zhuang, Nian, Thomas, John, Galatsis, Paul, Wendt, John A., Mickelson, John W., Schwarz, Roy D., Kinsora, Jack J., Lotarski, Susan M., Stakich, Korana, Gillespie, Kristen K., Lam, Wing W., Mutlib, Abdul E.

“…Rational replacement of the alkyne linker of mGluR5 antagonist MPEP gave 7-arylquinolines. SAR optimization gave an orally active compound with high affinity…”
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Chemistry of the phenoxathiins and isosterically related heterocycles. XXXII . The synthesis of 2-azathianthrene and selected analogs by Lam, Wing W., Martin, Gary E., Lynch, Vincent M., Simonsen, Stanley H., Lindsay, Charles M., Smith, Keith

“…The synthesis of 2‐azathianthrene ([1,4]benzodithiino[2,3‐c]pyridine), the only remaining monoazathianthrene yet to be reported, is described. Attempts at the…”
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The role of the red blood cell in the transport of carbon disulfide by Lam, C W, DiStefano, V, Morken, D A

“…When rats were exposed to 2 mg l-1 (approximately 640 ppm) of carbon disulfide (CS2) for 4 h, the concentration of free CS2 in the red blood cells (RBCs)…”
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