Search Results - "Lam, Wilfred W"

Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and analysis of the field-dependent saturation spectrum by van Zijl, Peter C.M., Lam, Wilfred W., Xu, Jiadi, Knutsson, Linda, Stanisz, Greg J.

“…Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation Transfer (CEST) experiments measure the transfer of magnetization from molecular protons…”
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Chemical Exchange Saturation Transfer MRI for Differentiating Radiation Necrosis From Tumor Progression in Brain Metastasis—Application in a Clinical Setting by Mehrabian, Hatef, Chan, Rachel W., Sahgal, Arjun, Chen, Hanbo, Theriault, Aimee, Lam, Wilfred W., Myrehaug, Sten, Tseng, Chia‐Lin, Husain, Zain, Detsky, Jay, Soliman, Hany, Stanisz, Greg J.

“…Background High radiation doses of stereotactic radiosurgery (SRS) for brain metastases (BM) can increase the likelihood of radiation necrosis (RN). Advanced…”
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Saturation transfer MRI is sensitive to neurochemical changes in the rat brain due to chronic unpredictable mild stress by Pankowska, Anna, Chudzik, Agata, Słowik, Tymoteusz, Łazorczyk, Artur, Kochalska, Katarzyna, Andres-Mach, Marta, Lam, Wilfred W., Pietura, Radosław, Rola, Radosław, Stanisz, Greg J., Orzyłowska, Anna

“…Chemical exchange saturation transfer (CEST) MRI was performed for the evaluation of cerebral metabolic changes in a rat model of depressive-like disease…”
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Chemical Exchange Saturation Transfer MRI: What Neuro-Oncology Clinicians Need To Know by Jabehdar Maralani, Pejman, Chan, Rachel W., Lam, Wilfred W., Oakden, Wendy, Oglesby, Ryan, Lau, Angus, Mehrabian, Hatef, Heyn, Chris, Chan, Aimee K.M., Soliman, Hany, Sahgal, Arjun, Stanisz, Greg J.

“…Chemical exchange saturation transfer (CEST) is a relatively novel magnetic resonance imaging (MRI) technique with an image contrast designed for in vivo…”
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Chemical exchange saturation transfer MRI to assess cell death in breast cancer xenografts at 7T by Klein, Jonathan, Lam, Wilfred W, Czarnota, Gregory J, Stanisz, Greg J

“…Detecting cell death and predicting tumor response early in a course of chemotherapy could help optimize treatment regimens and improve clinical outcomes…”
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Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-13C2]pyruvate in vivo by Chen, Albert P., Hurd, Ralph E., Schroeder, Marie A., Lau, Angus Z., Gu, Yi-ping, Lam, Wilfred W., Barry, Jennifer, Tropp, James, Cunningham, Charles H.

“…13C MR spectroscopy studies performed on hearts ex vivo and in vivo following perfusion of prepolarized [1‐13C]pyruvate have shown that changes in pyruvate…”
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In vitro characterization of the serotonin biosynthesis pathway by CEST MRI by Oglesby, Ryan T., Lam, Wilfred W., Stanisz, Greg J.

“…Purpose The diagnosis of monoamine‐related psychiatric disorders is based on the phenomenological evaluation of symptoms and behavior by trained clinicians…”
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Glioblastoma (GBM) effects on quantitative MRI of contralateral normal appearing white matter by Mehrabian, Hatef, Lam, Wilfred W., Myrehaug, Sten, Sahgal, Arjun, Stanisz, Greg J.

“…Purpose The objective was to investigate (with quantitative MRI) whether the normal appearing white matter (NAWM) of glioblastoma (GBM) patients on the…”
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Saturation transfer (CEST and MT) MRI for characterization of U-87 MG glioma in the rat by Lam, Wilfred W, Chudzik, Agata, Lehman, Natalia, Łazorczyk, Artur, Kozioł, Paulina, Niedziałek, Anna, Gananathan, Athavan, Orzyłowska, Anna, Rola, Radosław, Stanisz, Greg J

“…The focus of this work was to identify the optimal magnetic resonance imaging (MRI) contrast between orthotopic U-87 MG tumours and normal appearing brain with…”
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A strategy to prevent a temperature‐induced MRI artifact in warm liquid phantoms due to convection currents by Oglesby, Ryan T., Lam, Wilfred W., Stanisz, Greg J.

“…MRI phantom studies often fail to mimic the temperature of the human body, which can negatively impact accuracy. An artifact induced by increasing temperature…”
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Additional Cover by Oglesby, Ryan T., Lam, Wilfred W., Stanisz, Greg J.

“…The cover image is based on the Research Article A strategy to prevent a temperature‐induced MRI artifact in warm liquid phantoms due to convection currents by…”
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Early alterations in brain glucose metabolism and vascular function in a transgenic rat model of Alzheimer’s disease by Joo, Illsung L., Lam, Wilfred W., Oakden, Wendy, Hill, Mary E., Koletar, Margaret M., Morrone, Christopher D., Stanisz, Greg J., McLaurin, JoAnne, Stefanovic, Bojana

“…Alteration in brain metabolism predates clinical onset of Alzheimer’s Disease (AD). Realizing its potential as an early diagnostic marker, however, requires…”
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Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart by Lau, Angus Z., Chen, Albert P., Ghugre, Nilesh R., Ramanan, Venkat, Lam, Wilfred W., Connelly, Kim A., Wright, Graham A., Cunningham, Charles H.

“…Hyperpolarization of spins via dynamic nuclear polarization (DNP) has been explored as a method to non‐invasively study real‐time metabolic rocesses occurring…”
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A model for extra-axonal diffusion spectra with frequency-dependent restriction by Lam, Wilfred W., Jbabdi, Saâd, Miller, Karla L.

“…Purpose In the brain, there is growing interest in using the temporal diffusion spectrum to characterize axonal geometry in white matter because of the…”
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Skull phantom‐based methodology to validate MRI co‐registration accuracy for Gamma Knife radiosurgery by Oglesby, Ryan T., Lam, Wilfred W., Ruschin, Mark, Holden, Lori, Sarfehnia, Arman, Yeboah, Collins, Sahgal, Arjun, Soliman, Hany, Detsky, Jay, Tseng, Chia‐Lin, Myrehaug, Sten, Husain, Zain, Lau, Angus Z., Stanisz, Greg J., Chugh, Brige P.

“…Purpose Target localization, for stereotactic radiosurgery (SRS) treatment with Gamma Knife, has become increasingly reliant on the co‐registration between the…”
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An Automated Segmentation Pipeline for Intratumoural Regions in Animal Xenografts Using Machine Learning and Saturation Transfer MRI by Lam, Wilfred W., Oakden, Wendy, Karami, Elham, Koletar, Margaret M., Murray, Leedan, Liu, Stanley K., Sadeghi-Naini, Ali, Stanisz, Greg J.

“…Saturation transfer MRI can be useful in the characterization of different tumour types. It is sensitive to tumour metabolism, microstructure, and…”
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Saturation transfer properties of tumour xenografts derived from prostate cancer cell lines 22Rv1 and DU145 by Tan, Ziyu, Lam, Wilfred W., Oakden, Wendy, Murray, Leedan, Koletar, Margaret M., Liu, Stanley K., Stanisz, Greg J.

“…Histopathology is currently the most reliable tool in assessing the aggressiveness and prognosis of solid tumours. However, developing non-invasive modalities…”
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Hydrazo‐CEST: Hydrazone‐Dependent Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents by Dang, Trina, Suchy, Mojmír, Truong, Yen J., Oakden, Wendy, Lam, Wilfred W., Lazurko, Caitlin, Facey, Glenn, Stanisz, Greg J., Shuhendler, Adam J.

“…The rapid formation of hydrazones under physiological conditions was exploited for the detection of aldehydes through chemical exchange saturation transfer…”
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Differentiation of Normal and Radioresistant Prostate Cancer Xenografts Using Magnetization Transfer-Prepared MRI by Lam, Wilfred W., Oakden, Wendy, Murray, Leedan, Klein, Jonathan, Iorio, Caterina, Screaton, Robert A., Koletar, Margaret M., Chu, William, Liu, Stanley K., Stanisz, Greg J.

“…The ability of MRI to differentiate between normal and radioresistant cancer was investigated in prostate tumour xenografts in mice. Specifically, the process…”
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Choice of reference measurements affects quantification of long diffusion time behaviour using stimulated echoes by Kleinnijenhuis, Michiel, Mollink, Jeroen, Lam, Wilfred W., Kinchesh, Paul, Khrapitchev, Alexandre A., Smart, Sean C., Jbabdi, Saad, Miller, Karla L.

“…Purpose To demonstrate how reference data affect the quantification of the apparent diffusion coefficient (ADC) in long diffusion time measurements with…”
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