Search Results - "Lam, Wan L."

cGAS–STING and Cancer: Dichotomous Roles in Tumor Immunity and Development by Ng, Kevin W., Marshall, Erin A., Bell, John C., Lam, Wan L.

“…cGMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) sensing has emerged as a key regulator of innate immune responses to both exogenous and…”
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The functional role of long non-coding RNA in human carcinomas by Gibb, Ewan A, Brown, Carolyn J, Lam, Wan L

“…Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive…”
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Environmental arsenic exposure: From genetic susceptibility to pathogenesis by Minatel, Brenda C., Sage, Adam P., Anderson, Christine, Hubaux, Roland, Marshall, Erin A., Lam, Wan L., Martinez, Victor D.

“…More than 200 million people in 70 countries are exposed to arsenic through drinking water. Chronic exposure to this metalloid has been associated with the…”
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Health Effects Associated With Pre- and Perinatal Exposure to Arsenic by Martinez, Victor D, Lam, Wan L

“…Inorganic arsenic is a well-established human carcinogen, able to induce genetic and epigenetic alterations. More than 200 million people worldwide are exposed…”
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Piwi-interacting RNAs in cancer: emerging functions and clinical utility by Ng, Kevin W, Anderson, Christine, Marshall, Erin A, Minatel, Brenda C, Enfield, Katey S S, Saprunoff, Heather L, Lam, Wan L, Martinez, Victor D

“…PIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics. Originally described in the germline, there are over 20,000 piRNA genes in the human…”
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Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study by Lalonde, Emilie, MSc, Ishkanian, Adrian S, MD, Sykes, Jenna, MMath, Fraser, Michael, PhD, Ross-Adams, Helen, PhD, Erho, Nicholas, MSc, Dunning, Mark J, PhD, Halim, Silvia, MSc, Lamb, Alastair D, FRCS, Moon, Nathalie C, MMath, Zafarana, Gaetano, PhD, Warren, Anne Y, FRCPath, Meng, Xianyue, MSc, Thoms, John, MD, Grzadkowski, Michal R, BMath, Berlin, Alejandro, MD, Have, Cherry L, BSc, Ramnarine, Varune R, BCS, Yao, Cindy Q, MSc, Malloff, Chad A, MSc, Lam, Lucia L, BSc, Xie, Honglei, MMath, Harding, Nicholas J, PhD, Mak, Denise Y F, PhD, Chu, Kenneth C, PhD, Chong, Lauren C, BCS, Sendorek, Dorota H, BSc, P'ng, Christine, BSc, Collins, Colin C, Prof, Squire, Jeremy A, Prof, Jurisica, Igor, Prof, Cooper, Colin, PhD, Eeles, Rosalind, Prof, Pintilie, Melania, MSc, Dal Pra, Alan, MD, Davicioni, Elai, PhD, Lam, Wan L, Prof, Milosevic, Michael, MD, Neal, David E, Prof, van der Kwast, Theodorus, Prof, Boutros, Paul C, Prof, Bristow, Robert G, Prof

“…Summary Background Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided…”
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Lung Cancer Cell Lines as Tools for Biomedical Discovery and Research by Gazdar, Adi F., Girard, Luc, Lockwood, William W., Lam, Wan L., Minna, John D.

“…Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. A systematic approach to initiating…”
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Human cancer long non-coding RNA transcriptomes by Gibb, Ewan A, Vucic, Emily A, Enfield, Katey S S, Stewart, Greg L, Lonergan, Kim M, Kennett, Jennifer Y, Becker-Santos, Daiana D, MacAulay, Calum E, Lam, Stephen, Brown, Carolyn J, Lam, Wan L

“…Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian…”
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Comprehensive Analysis of Lung Adenocarcinoma and Brain Metastasis through Integrated Single-Cell Transcriptomics by Souza, Vanessa G P, Telkar, Nikita, Lam, Wan L, Reis, Patricia P

“…Lung adenocarcinoma (LUAD) is a highly prevalent and lethal form of lung cancer, comprising approximately half of all cases. It is often diagnosed at advanced…”
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Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology by Martinez, Victor D., Vucic, Emily A., Thu, Kelsie L., Hubaux, Roland, Enfield, Katey S.S., Pikor, Larissa A., Becker-Santos, Daiana D., Brown, Carolyn J., Lam, Stephen, Lam, Wan L.

“…Human PIWI-interacting RNAs (piRNAs) are known to be expressed in germline cells, functionally silencing LINEs and SINEs. Their expression patterns in somatic…”
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Distinct bronchial microbiome precedes clinical diagnosis of lung cancer by Marshall, Erin A, Filho, Fernando S L, Sin, Don D, Lam, Stephen, Leung, Janice M, Lam, Wan L

“…Resident microbial populations have been detected across solid tumors of diverse origins. Sequencing of the airway microbiota represents an opportunity for…”
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Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer by Coe, Bradley P, Thu, Kelsie L, Aviel-Ronen, Sarit, Vucic, Emily A, Gazdar, Adi F, Lam, Stephen, Tsao, Ming-Sound, Lam, Wan L

“…Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm with extremely poor clinical outcomes and no approved targeted treatments. To elucidate the…”
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A Comprehensive Analysis of Common Copy-Number Variations in the Human Genome by Wong, Kendy K., deLeeuw, Ronald J., Dosanjh, Nirpjit S., Kimm, Lindsey R., Cheng, Ze, Horsman, Douglas E., MacAulay, Calum, Ng, Raymond T., Brown, Carolyn J., Eichler, Evan E., Lam, Wan L.

“…Segmental copy-number variations (CNVs) in the human genome are associated with developmental disorders and susceptibility to diseases. More importantly, CNVs…”
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Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma by Enfield, Katey S. S., Marshall, Erin A., Anderson, Christine, Ng, Kevin W., Rahmati, Sara, Xu, Zhaolin, Fuller, Megan, Milne, Katy, Lu, Daniel, Shi, Rocky, Rowbotham, David A., Becker-Santos, Daiana D., Johnson, Fraser D., English, John C., MacAulay, Calum E., Lam, Stephen, Lockwood, William W., Chari, Raj, Karsan, Aly, Jurisica, Igor, Lam, Wan L.

“…Gene function in cancer is often cell type-specific. The epithelial cell-specific transcription factor ELF3 is a documented tumor suppressor in many epithelial…”
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Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer by Crea, Francesco, Watahiki, Akira, Quagliata, Luca, Xue, Hui, Pikor, Larissa, Parolia, Abhijit, Wang, Yuwei, Lin, Dong, Lam, Wan L, Farrar, William L, Isogai, Takao, Morant, Rudolf, Castori-Eppenberger, Serenella, Chi, Kim N, Wang, Yuzhuo, Helgason, Cheryl D

“…Metastatic prostate cancer (PCa) is still an incurable disease. Long non-coding RNAs (lncRNAs) may be an overlooked source of cancer biomarkers and therapeutic…”
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Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells by Soh, Junichi, Okumura, Naoki, Lockwood, William W, Yamamoto, Hiromasa, Shigematsu, Hisayuki, Zhang, Wei, Chari, Raj, Shames, David S, Tang, Ximing, MacAulay, Calum, Varella-Garcia, Marileila, Vooder, Tõnu, Wistuba, Ignacio I, Lam, Stephen, Brekken, Rolf, Toyooka, Shinichi, Minna, John D, Lam, Wan L, Gazdar, Adi F

“…Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis. However, mutant allele…”
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PIK3CA Mutations and Copy Number Gains in Human Lung Cancers by YAMAMOTO, Hiromasa, SHIGEMATSU, Hisayuki, LEE, Huei, TOYOOKA, Shinichi, DATE, Hiroshi, LAM, Wan L, MINNA, John D, GAZDAR, Adi F, NOMURA, Masaharu, LOCKWOOD, William W, SATO, Mitsuo, OKUMURA, Naoki, SOH, Junichi, SUZUKI, Makoto, WISTUBA, Ignacio I, FONG, Kwun M

“…We investigated the frequency and function of mutations and increased copy number of the PIK3CA gene in lung cancers. PIK3CA mutations are one of the most…”
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Mechanisms Contributing to the Comorbidity of COPD and Lung Cancer by Forder, Aisling, Zhuang, Rebecca, Souza, Vanessa G P, Brockley, Liam J, Pewarchuk, Michelle E, Telkar, Nikita, Stewart, Greg L, Benard, Katya, Marshall, Erin A, Reis, Patricia P, Lam, Wan L

“…Lung cancer and chronic obstructive pulmonary disease (COPD) often co-occur, and individuals with COPD are at a higher risk of developing lung cancer. While…”
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Arsenic Exposure and the Induction of Human Cancers by Martinez, Victor D., Vucic, Emily A., Becker-Santos, Daiana D., Gil, Lionel, Lam, Wan L.

“…Arsenic is a metalloid, that is, considered to be a human carcinogen. Millions of individuals worldwide are chronically exposed through drinking water, with…”
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Patient-Derived First Generation Xenografts of Non-Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy by XIN DONG, JUN GUAN, LAM, Wan L, LASKIN, Janessa, LING, Victor, LAM, Stephen, YUZHUO WANG, ENGLISH, John C, FLINT, Julia, YEE, John, EVANS, Kenneth, MURRAY, Nevin, MACAULAY, Calum, NG, Raymond T, GOUT, Peter W

“…Current chemotherapeutic regimens have only modest benefit for non-small cell lung cancer (NSCLC) patients. Cumulative toxicities/drug resistance limit…”
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