Search Results - "Lam, Viola C"
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KLF12 Regulates Mouse NK Cell Proliferation
Published in The Journal of immunology (1950) (15-08-2019)“…NK cells are innate lymphocytes that play an integral role in tumor rejection and viral clearance. Unlike their other lymphocyte counterparts, NK cells have…”
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NK cells in host responses to viral infections
Published in Current opinion in immunology (01-02-2017)“…Highlights • NK cells generate long-lived antigen-specific memory cells. • NK cells regulate viral load and cytokine production of innate immune cells. • NK…”
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Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response
Published in Science translational medicine (14-09-2011)“…Delivery of bone marrow cells (BMCs) to the heart has substantially improved cardiac function in most rodent models of myocardial infarction (MI), but clinical…”
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Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses
Published in Proceedings of the National Academy of Sciences - PNAS (13-01-2009)“…The cooperative activity of protein tyrosine kinases and phosphatases plays a central role in regulation of T cell receptor (TCR) signal strength. Perturbing…”
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Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production
Published in The Journal of immunology (1950) (15-04-2015)“…The autoimmune disease systemic lupus erythematosus has a complex environmental and multifactorial genetic basis. Genome-wide association studies have recently…”
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278 Preclinical development of LYL119, a ROR1-targeted CAR T-cell product incorporating four novel T-cell reprogramming technologies to overcome barriers to effective cell therapy for solid tumors
Published in Journal for immunotherapy of cancer (01-11-2023)“…BackgroundEffective solid tumor cell therapy requires new strategies to improve T-cell activation, persistence, and durable function. 1 2 We developed four…”
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KLF12 regulates mouse Natural Killer cell proliferation
Published in The Journal of immunology (1950) (12-07-2019)“…Natural killer (NK) cells are innate lymphocytes that play an integral role in tumor rejection and viral clearance. Unlike their other lymphocyte counterparts,…”
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Abstract 49: LYL119, an investigational ROR1-targeted CAR T-cell product incorporating four novel reprogramming technologies designed for effective cell therapy for solid tumors
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Effective solid tumor cell therapy requires new strategies to improve T-cell activation, persistence, and durable function. We developed four complementary…”
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Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production1
Published in The Journal of immunology (1950) (13-03-2015)“…The autoimmune disease systemic lupus erythematosus (SLE) has a complex environmental and multi-factorial genetic basis. Genome wide association studies have…”
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