Search Results - "Lam, Tony"

The metabolic impact of small intestinal nutrient sensing by Duca, Frank A., Waise, T. M. Zaved, Peppler, Willem T., Lam, Tony K. T.

“…The gastrointestinal tract maintains energy and glucose homeostasis, in part through nutrient-sensing and subsequent signaling to the brain and other tissues…”
Get full text

Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats by Duca, Frank A, Côté, Clémence D, Rasmussen, Brittany A, Zadeh-Tahmasebi, Melika, Rutter, Guy A, Filippi, Beatrice M, Lam, Tony K T

“…Two papers show that Ampk and Sirt1 respond to metformin and resveratrol, respectively, in the duodenum to initiate a gut-brain-liver axis that reduces hepatic…”
Get full text

Peripheral and central regulation of insulin by the intestine and microbiome by Schertzer, Jonathan D, Lam, Tony K T

“…Blood glucose and insulin homeostasis is disrupted during the progression of type 2 diabetes. Insulin levels and action are regulated by both peripheral and…”
Get more information

The Gut Microbiome: Connecting Diet, Glucose Homeostasis, and Disease by Howard, Elizabeth J, Lam, Tony K.T, Duca, Frank A

“…Type 2 diabetes rates continue to rise unabated, underscoring the need to better understand the etiology and potential therapeutic options available for this…”
Get full text

Immunologic impact of the intestine in metabolic disease by Winer, Daniel A, Winer, Shawn, Dranse, Helen J, Lam, Tony K T

“…Obesity and diabetes are associated with increased chronic low-grade inflammation and elevated plasma glucose levels. Although inflammation in the fat and…”
Get full text

Glucagon action in the brain by Abraham, Mona A., Lam, Tony K. T.

“…In recent years, novel discoveries have reshaped our understanding of the biology of brain glucagon in the regulation of peripheral homeostasis. Here we…”
Get full text

The metabolic role of vagal afferent innervation by Waise, T. M. Zaved, Dranse, Helen J., Lam, Tony K. T.

“…The regulation of energy and glucose balance contributes to whole-body metabolic homeostasis, and such metabolic regulation is disrupted in obesity and…”
Get full text

Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway by Bauer, Paige V., Duca, Frank A., Waise, T.M. Zaved, Rasmussen, Brittany A., Abraham, Mona A., Dranse, Helen J., Puri, Akshita, O’Brien, Catherine A., Lam, Tony K.T.

“…The gut microbiota alters energy homeostasis. In parallel, metformin regulates upper small intestinal sodium glucose cotransporter-1 (SGLT1), but whether…”
Get full text

Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents by Luck, Helen, Tsai, Sue, Chung, Jason, Clemente-Casares, Xavier, Ghazarian, Magar, Revelo, Xavier S., Lei, Helena, Luk, Cynthia T., Shi, Sally Yu, Surendra, Anuradha, Copeland, Julia K., Ahn, Jennifer, Prescott, David, Rasmussen, Brittany A., Chng, Melissa Hui Yen, Engleman, Edgar G., Girardin, Stephen E., Lam, Tony K.T., Croitoru, Kenneth, Dunn, Shannon, Philpott, Dana J., Guttman, David S., Woo, Minna, Winer, Shawn, Winer, Daniel A.

“…Obesity has reached epidemic proportions, but little is known about its influence on the intestinal immune system. Here we show that the gut immune system…”
Get full text

Neuronal regulation of homeostasis by nutrient sensing by Lam, Tony K T

“…In type 2 diabetes and obesity, the homeostatic control of glucose and energy balance is impaired, leading to hyperglycemia and hyperphagia. Recent studies…”
Get full text

Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes by BREEN, Danna M, RASMUSSEN, Brittany A, COTE, Clémence D, MARGARET JACKSON, V, LAM, Tony K. T

“…The small intestine is traditionally viewed as an organ that mediates nutrient digestion and absorption. This view has recently been revised owing to the…”
Get full text

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network by Côté, Clémence D, Rasmussen, Brittany A, Duca, Frank A, Zadeh-Tahmasebi, Melika, Baur, Joseph A, Daljeet, Mira, Breen, Danna M, Filippi, Beatrice M, Lam, Tony K T

“…Two papers show that Ampk and Sirt1 respond to metformin and resveratrol, respectively, in the duodenum to initiate a gut-brain-liver axis that reduces hepatic…”
Get full text

Obesity and the kidney: mechanistic links and therapeutic advances by Yau, Kevin, Kuah, Rachel, Cherney, David Z. I., Lam, Tony K. T.

“…Obesity is strongly associated with the development of diabetes mellitus and chronic kidney disease (CKD), but there is evidence for a bidirectional…”
Get full text

Meta-analysis of microbiome association networks reveal patterns of dysbiosis in diseased microbiomes by Lam, Tony J., Ye, Yuzhen

“…The human gut microbiome is composed of a diverse and dynamic population of microbial species which play key roles in modulating host health and physiology…”
Get full text

Metabolic regulation by the intestinal metformin-AMPK axis by Zhang, Song-Yang, Lam, Tony K. T.

“…AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the antidiabetic agent metformin, but the sites of action remain unclear. In the…”
Get full text

Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes by Breen, Danna M, Rasmussen, Brittany A, Kokorovic, Andrea, Wang, Rennian, Cheung, Grace W C, Lam, Tony K T

“…Tony Lam and his colleagues show that the middle intestine senses glucose and has a role in a gut-brain-liver axis to regulate hepatic glucose production. They…”
Get full text

Artificial neural networks for energy analysis of office buildings with daylighting by Wong, S.L., Wan, Kevin K.W., Lam, Tony N.T.

“…An artificial neural network (ANN) model was developed for office buildings with daylighting for subtropical climates. A total of nine variables were used as…”
Get full text

Model-based and phylogenetically adjusted quantification of metabolic interaction between microbial species by Lam, Tony J, Stamboulian, Moses, Han, Wontack, Ye, Yuzhen

“…Microbial community members exhibit various forms of interactions. Taking advantage of the increasing availability of microbiome data, many computational…”
Get full text

Hypothalamic Leucine Metabolism Regulates Liver Glucose Production by YA SU, LAM, Tony K. T, WU HE, POCAI, Alessandro, BRYAN, Joseph, AGUILAR-BRYAN, Lydia, GUTIERREZ-JUAREZ, Roger

“…Amino acids profoundly affect insulin action and glucose metabolism in mammals. Here, we investigated the role of the mediobasal hypothalamus (MBH), a key…”
Get full text

Insulin: A GOAT of medical discovery by Lam, Tony K T

Get full text