Search Results - "Lam, Tim T."

Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models by Tse, Dennis Yan-yin, Lam, Tim T., To, Chi-ho, Abokyi, Samuel

“…Age-related macular degeneration (AMD) is a common cause of visual impairment in the elderly. There are very limited therapeutic options for AMD with the…”
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Axonal and Cell Body Protection By Nicotinamide Adenine Dinucleotide in Tumor Necrosis Factor-Induced Optic Neuropathy by Kitaoka, Yasushi, Hayashi, Yasuhiro, Kumai, Toshio, Takeda, Hiroyuki, Munemasa, Yasunari, Fujino, Hiromi, Kitaoka, Yuka, Ueno, Satoki, Sadun, Alfredo A, Lam, Tim T

“…Axonal degeneration often leads to the death of neuronal cell bodies. Previous studies have demonstrated the crucial role of nicotinamide adenine dinucleotide…”
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Hyperthermic pre-conditioning protects retinal neurons from N-methyl- d-aspartate (NMDA)-induced apoptosis in rat by Kwong, Jacky M.K., Lam, Tim T., Caprioli, Joseph

“…Glutamate-induced excitotoxicity is associated with a selective loss of retinal neurons after retinal ischemia and possibly in glaucoma. Since heat shock…”
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Relative contribution of VEGF and TNF-alpha in the cynomolgus laser-induced CNV model: comparing the efficacy of bevacizumab, adalimumab, and ESBA105 by Lichtlen, Peter, Lam, Tim T, Nork, T Michael, Streit, Tim, Urech, David M

“…To compare the relative contribution of VEGF and TNF-alpha in the development of laser-induced choroidal neovascularization (CNV) in monkeys and to exploit the…”
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N-methyl-D-aspartate (NMDA) induced apoptosis in adult rabbit retinas by KWONG, Jacky M. K, LAM, Tim T

“…Previously we showed that apoptosis is involved in N -methyl- D -aspartate (NMDA) induced excitotoxicity in adult rat retinas. Since rabbits have a higher…”
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Interleukin-6 in Retinal Ischemia Reperfusion Injury in Rats by Sanchez, Ruben N, Chan, Candy K, Garg, Sumit, Kwong, Jacky M. K, Wong, Micheline J, Sadun, Alfredo A, Lam, Tim T

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Heterogeneous populations of microglia/macrophages in the retina and their activation after retinal ischemia and reperfusion injury by Zhang, Cheng, Lam, Tim T., Tso, Mark OM

“…Activation of Microglia/macrophages has been observed in ischemia-reperfusion injury of the brain. This study was undertaken to investigate the different…”
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TNF-α-induced optic nerve degeneration and nuclear factor-κB p65 by KITAOKA, Yasushi, KITAOKA, Yuka, KWONG, Jacky M. K, ROSS-CISNEROS, Fred N, JIANTAO WANG, RONG KUNG TSAI, SADUN, Alfredo A, LAM, Tim T

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Activation of microglia and chemokines in light-induced retinal degeneration by Zhang, Cheng, Shen, Ji-Kui, Lam, Tim T, Zeng, Hui-Yang, Chiang, Samuel K, Yang, Fang, Tso, Mark O M

“…Microglial cells, which are activated and recruited by chemokines, have been shown to play crucial roles in neuronal degenerations of the central nervous…”
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N-Methyl-D-Aspartate (NMDA)-Induced Apoptosis in Rat Retina by Lam, Tim T, Abler, Andrew S, Kwong, Jacky M. K, Tso, Mark O. M

“…The involvement of apoptosis in N-methyl-D-aspartate (NMDA)-induced excitotoxicity in adult rat retinas was examined. Excitotoxic loss of inner retinal…”
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Neuroprotection of Photoreceptors by Minocycline in Light-Induced Retinal Degeneration by Zhang, Cheng, Lei, Bo, Lam, Tim T, Yang, Fang, Sinha, Debasish, Tso, Mark O. M

“…Microglial cells have been found to play pivotal roles in various neuronal degenerative diseases such as Parkinson's and Alzheimer's diseases. Minocycline, a…”
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Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina by Kitaoka, Yuka, Kitaoka, Yasushi, Kumai, Toshio, Lam, Tim T, Kuribayashi, Kohei, Isenoumi, Kazuyuki, Munemasa, Yasunari, Motoki, Masamitsu, Kobayashi, Shinichi, Ueno, Satoki

“…RhoA, a key protein involved in cytoskeleton regulation modulating neurogenesis and neural plasticity, has been implicated in a variety of cellular functions…”
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Nuclear factor-kappa B p65 in NMDA-induced retinal neurotoxicity by Kitaoka, Yasushi, Kumai, Toshio, Kitaoka, Yuka, Lam, Tim T., Munemasa, Yasunari, Isenoumi, Kazuyuki, Motoki, Masamitsu, Kuribayashi, Kohei, Kogo, Jiro, Kobayashi, Shinichi, Ueno, Satoki

“…Transcription factors of the nuclear factor-kappa B (NF-κB)/Rel family may be involved in neuronal cell death or survival. We examined the role of NF-κB p65 in…”
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Early Glial Responses after Acute Elevated Intraocular Pressure in Rats by Lam, Tim T, Kwong, Jacky M. K, Tso, Mark O. M

“…To study the responses of glial cells to a short-term elevation in intraocular pressure (IOP) in rats. Adult Sprague-Dawley albino rats, 45 to 55 days old,…”
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Neuroprotective effects of the β-carboline abecarnil studied in cultured cortical neurons and organotypic retinal cultures by Ruscher, Karsten, Rzeczinski, Stefan, Thein, Elisabeth, Freyer, Dorette, Victorov, Ilya V., Lam, Tim T., Dirnagl, Ulrich

“…Presently there is no neuroprotective pharmacological treatment of proven clinical safety and efficacy available. The purpose of this study was to investigate…”
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Nuclear factor-κB p65 and upregulation of interleukin-6 in retinal ischemia/reperfusion injury in rats by Wang, Jiantao, Jiang, Shaoyun, Kwong, Jacky M.K., Sanchez, Ruben N., Sadun, Alfredo A., Lam, Tim T.

“…We previously demonstrated that endogenous interleukin-6 (IL-6) is upregulated and may be neuroprotective after retinal ischemia. The purpose of this study is…”
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Disturbances in the distribution of neurotransmitters in the rat retina after ischemia by Perlman, J I, McCole, S M, Pulluru, P, Chang, C J, Lam, T T, Tso, M O

“…Disturbances in neurotransmitter distribution have been observed in cerebral ischemia in the pathophysiologic process of excitotoxicity. The goal of this study…”
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The effects of naloxone on retinal ischemia in rats by Lam, T T, Takahashi, K, Tso, M O

“…The efficacy of naloxone (NL), a broad spectrum opioid antagonist, on retinal ischemia, was evaluated in a rat model of retinal ischemia with histopathologic…”
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Apoptosis and caspases after ischemia-reperfusion injury in rat retina by Lam, TT, Abler, AS, Tso, MO

“…Extensive cell loss in the retinal ganglion cell layer (RGCL) and the inner nuclear layer (INL) was noted in a rat model of retinal ischemia-reperfusion injury…”
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Interleukin-6 in retinal ischemia reperfusion injury in rats by Sanchez, Ruben N, Chan, Candy K, Garg, Sumit, Kwong, Jacky M K, Wong, Micheline J, Sadun, Alfredo A, Lam, Tim T

“…To study the role of interleukin (IL)-6 after retinal ischemia-reperfusion (I/R) injury in rats. Intraocular pressure of adult male Lewis albino rats was…”
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