Search Results - "Lam, Ruby M"

The Form and Function of PIEZO2 by Szczot, Marcin, Nickolls, Alec R, Lam, Ruby M, Chesler, Alexander T

“…Mechanosensation is the ability to detect dynamic mechanical stimuli (e.g., pressure, stretch, and shear stress) and is essential for a wide variety of…”
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Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells by Nickolls, Alec R., Lee, Michelle M., Espinoza, David F., Szczot, Marcin, Lam, Ruby M., Wang, Qi, Beers, Jeanette, Zou, Jizhong, Nguyen, Minh Q., Solinski, Hans J., AlJanahi, Aisha A., Johnson, Kory R., Ward, Michael E., Chesler, Alexander T., Bönnemann, Carsten G.

“…Efficient and homogeneous in vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms and disease models of…”
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Human Stem Cell-Derived TRPV1-Positive Sensory Neurons: A New Tool to Study Mechanisms of Sensitization by Schrenk-Siemens, Katrin, Pohle, Jörg, Rostock, Charlotte, Abd El Hay, Muad, Lam, Ruby M, Szczot, Marcin, Lu, Shiying, Chesler, Alexander T, Siemens, Jan

“…Somatosensation, the detection and transduction of external and internal stimuli such as temperature or mechanical force, is vital to sustaining our bodily…”
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Decoding Cellular Mechanisms for Mechanosensory Discrimination by von Buchholtz, Lars J., Ghitani, Nima, Lam, Ruby M., Licholai, Julia A., Chesler, Alexander T., Ryba, Nicholas J.P.

“…Single-cell RNA-sequencing and in vivo functional imaging provide expansive but disconnected views of neuronal diversity. Here, we developed a strategy for…”
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PIEZO2 in somatosensory neurons controls gastrointestinal transit by Servin-Vences, M. Rocio, Lam, Ruby M., Koolen, Alize, Wang, Yu, Saade, Dimah N., Loud, Meaghan, Kacmaz, Halil, Frausto, Suzanne, Zhang, Yunxiao, Beyder, Arthur, Marshall, Kara L., Bönnemann, Carsten G., Chesler, Alexander T., Patapoutian, Ardem

“…The gastrointestinal tract is in a state of constant motion. These movements are tightly regulated by the presence of food and help digestion by mechanically…”
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Assigning transcriptomic class in the trigeminal ganglion using multiplex in situ hybridization and machine learning by von Buchholtz, Lars J., Lam, Ruby M., Emrick, Joshua J., Chesler, Alexander T., Ryba, Nicholas J.P.

“…Single cell sequencing has provided unprecedented information about the transcriptomic diversity of somatosensory systems. Here, we describe a simple and…”
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PIEZO2 and perineal mechanosensation are essential for sexual function by Lam, Ruby M, von Buchholtz, Lars J, Falgairolle, Melanie, Osborne, Jennifer, Frangos, Eleni, Servin-Vences, M Rocio, Nagel, Maximilian, Nguyen, Minh Q, Jayabalan, Monessha, Saade, Dimah, Patapoutian, Ardem, Bönnemann, Carsten G, Ryba, Nicholas J P, Chesler, Alexander T

“…Despite the potential importance of genital mechanosensation for sexual reproduction, little is known about how perineal touch influences mating. We explored…”
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Shear elegance: A novel screen uncovers a mechanosensitive GPCR by Lam, Ruby M, Chesler, Alexander T

“…Lam and Chesler highlight the recent discovery of a G protein–coupled receptor involved in detecting mechanical shear stress…”
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