Search Results - "Lam, Paula Y P"

Combined treatment of Nimotuzumab and rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status by Chong, Dawn Q, Toh, Xin Y, Ho, Ivy A W, Sia, Kian C, Newman, Jennifer P, Yulyana, Yulyana, Ng, Wai-Hoe, Lai, Siang H, Ho, Mac M F, Dinesh, Nivedh, Tham, Chee K, Lam, Paula Y P

“…The treatment of glioblastoma multiforme (GBM) is an unmet clinical need. The 5-year survival rate of patients with GBM is less than 3%. Temozolomide (TMZ)…”
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The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants by Yuan, Jimin, Ng, Wan Hwa, Lam, Paula Y. P., Wang, Yu, Xia, Hongping, Yap, Jiajun, Guan, Shou Ping, Lee, Ann S. G., Wang, Mei, Baccarini, Manuela, Hu, Jiancheng

“…Although extensively studied for three decades, the molecular mechanisms that regulate the RAF/MEK/ERK kinase cascade remain ambiguous. Recent studies…”
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Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme by Newman, Jennifer P., Wang, Grace Y., Arima, Kazuhiko, Guan, Shou P., Waters, Michael R., Cavenee, Webster K., Pan, Edward, Aliwarga, Edita, Chong, Siao T., Kok, Catherine Y. L., Endaya, Berwini B., Habib, Amyn A., Horibe, Tomohisa, Ng, Wai H., Ho, Ivy A. W., Hui, Kam M., Kordula, Tomasz, Lam, Paula Y. P.

“…The interleukin-13 receptor alpha2 (IL-13Rα2) is a cancer-associated receptor overexpressed in human glioblastoma multiforme (GBM). This receptor is…”
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Human Bone Marrow‐Derived Mesenchymal Stem Cells Suppress Human Glioma Growth Through Inhibition of Angiogenesis by Ho, Ivy A.W., Toh, Han C, Ng, Wai H., Teo, Yuan L., Guo, Chang M., Hui, Kam M., Lam, Paula Y.P.

“…Tumor tropism of human bone marrow‐derived mesenchymal stem cells (MSC) has been exploited for the delivery of therapeutic genes for anticancer therapy…”
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Paracrine Factors of Human Fetal MSCs Inhibit Liver Cancer Growth Through Reduced Activation of IGF-1R/PI3K/Akt Signaling by Yulyana, Yulyana, Ho, Ivy A W, Sia, Kian Chuan, Newman, Jennifer P, Toh, Xin Yi, Endaya, Berwini B, Chan, Jerry K Y, Gnecchi, Massimiliano, Huynh, Hung, Chung, Alexander Y F, Lim, Kiat Hon, Leong, Hui Sun, Iyer, Narayanan Gopalakrishna, Hui, Kam Man, Lam, Paula Y P

“…Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death in the world. The multikinase inhibitor sorafenib only demonstrated marginal…”
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Matrix Metalloproteinase 1 Is Necessary for the Migration of Human Bone Marrow‐Derived Mesenchymal Stem Cells Toward Human Glioma by Ho, Ivy A. W., Chan, Kelly Y. W., Ng, Wai‐Hoe, Guo, Chang M., Hui, Kam M., Cheang, Philip, Lam, Paula Y. P.

“…Human mesenchymal stem cells (MSCs) have increasingly been used as cellular vectors for the delivery of therapeutic genes to tumors. However, the precise…”
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Isolation of peptide ligands that interact specifically with human glioma cells by Ho, Ivy A.W., Hui, Kam M., Lam, Paula Y.P.

“…Poor prognosis of high grade gliomas coupled with the difficulty of widespread delivery of therapeutic agents prompted the search into new molecular targets…”
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Matrix metalloproteinase‐1‐mediated mesenchymal stem cell tumor tropism is dependent on crosstalk with stromal derived growth factor 1/C‐X‐C chemokine receptor 4 axis by Ho, Ivy A. W., Yulyana, Yulyana, Sia, Kian C., Newman, Jennifer P., Guo, Chang M., Hui, Kam M., Lam, Paula Y. P.

“…Human bone marrow‐derived mesenchymal stem cells (MSCs) have the unique ability to home toward injuries or tumor sites. We have previously shown that the…”
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Biological effects of cancer-secreted factors on human mesenchymal stem cells by Lam, Paula Y P

“…Mesenchymal stem cells or mesenchymal stromal cells (MSCs) have been considered as a carrier of therapeutic gene because of their inherent ability to migrate…”
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Hybrid herpes simplex virus/Epstein-Barr virus amplicon viral vectors confer enhanced transgene expression in primary human tumors and human bone marrow-derived mesenchymal stem cells by Sia, Kian Chuan, Chong, Wei Kin, Ho, Ivy A. W., Yulyana, Yulyana, Endaya, Berwini, Huynh, Hung, Lam, Paula Y. P.

“…Background Herpes simplex virus type‐1 (HSV‐1) amplicon vectors are attractive tools for gene transfer because of their large DNA insert capacity, their broad…”
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IL13RA2 Is Differentially Regulated in Papillary Thyroid Carcinoma vs Follicular Thyroid Carcinoma by Chong, Siao Ting, Tan, Khee Ming, Kok, Catherine Y L, Guan, Shou Ping, Lai, Siang Hui, Lim, Cindy, Hu, Jiancheng, Sturgis, Charles, Eng, Charis, Lam, Paula Y P, Ngeow, Joanne

“…The interleukin-13 receptor alpha2 (IL13RA2), which is known to be overexpressed in glioblastoma multiforme, plays a role in various cellular processes such as…”
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Engineering an improved cell cycle-regulatable herpes simplex virus type 1 amplicon vector with enhanced transgene expression in proliferating cells yet attenuated activities in resting cells by Wang, Grace Y, Ho, Ivy A W, Sia, Kian C, Miao, L, Hui, Kam M, Lam, Paula Y P

“…We previously generated a herpes simplex virus type 1 (HSV-1)-based amplicon vector (denoted pC8-36) in which gene expression from the minimal cyclin A…”
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Optimal purification method for Herpes-based viral vectors that confers minimal cytotoxicity for systemic route of vector administration by Sia, Kian Chuan, Wang, Grace Y., Ho, Ivy A.W., Khor, Hong Yuan, Miao, Lv, Hui, Kam M., Lam, Paula Y.P.

“…Herpes simplex virus (HSV)-1 amplicon vectors could be packaged in the presence of replication-competent helper virus or in a helper virus-free system. In the…”
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Human mesenchymal stem cells preferentially migrate toward highly oncogenic human hepatocellular carcinoma cells with activated EpCAM signaling by Endaya, Berwini, Guan, Shou P, Newman, Jennifer P, Huynh, Hung, Sia, Kian C, Chong, Siao T, Kok, Catherine Y L, Chung, Alexander Y F, Liu, Bin B, Hui, Kam M, Lam, Paula Y P

“…The epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein that is regarded as one of the markers for tumor initiating cells (TIC) in…”
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Transcriptional profiling of dividing tumor cells detects intratumor heterogeneity linked to cell proliferation in a brain tumor model by Endaya, Berwini B., Lam, Paula Y.P., Meedeniya, Adrian C.B., Neuzil, Jiri

“…Intratumor heterogeneity is a primary feature of high-grade gliomas, complicating their therapy. As accumulating evidence suggests that intratumor…”
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Carbenoxolone enhances TRAIL-induced apoptosis through the upregulation of death receptor 5 and inhibition of gap junction intercellular communication in human glioma by Yulyana, Yulyana, Endaya, Berwini B, Ng, Wai H, Guo, Chang M, Hui, Kam M, Lam, Paula Y P, Ho, Ivy A W

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been used extensively in cancer therapy. However, more than half of glioblastoma multiforme…”
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Isolating dividing neural and brain tumour cells for gene expression profiling by Endaya, Berwini, Cavanagh, Brenton, Alowaidi, Faisal, Walker, Tom, de Pennington, Nicholas, Ng, Jin-Ming A., Lam, Paula Y.P., Mackay-Sim, Alan, Neuzil, Jiri, Meedeniya, Adrian C.B.

“…•RNA from dividing cells was isolated for gene expression analysis by EdU labelling.•RNA quality is dependent on reduced copper exposure and cell membrane…”
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Signaling molecules and pathways involved in MSC tumor tropism by Ho, Ivy A W, Lam, Paula Y P

“…Human bone marrow is a reservoir containing cells with different self-renewal capabilities, such as mesenchymal stem cells (MSC) and hematopoeitic stem cells…”
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Matrix metalloproteinase‐1 facilitates MSC migration via cleavage of IGF‐2/IGFBP2 complex by Guan, Shou P., Lam, Alan T.L., Newman, Jennifer P., Chua, Kevin L.M., Kok, Catherine Y.L., Chong, Siao T., Chua, Melvin L.K., Lam, Paula Y.P.

“…The specific mechanism underlying the tumor tropism of human mesenchymal stem cells (MSCs) for cancer is not well defined. We previously showed that the…”
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Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP5+, Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme by Yulyana, Yulyana, Tovmasyan, Artak, Ho, Ivy AW, Sia, Kian Chuan, Newman, Jennifer P, Ng, Wai Hoe, Guo, Chang Ming, Hui, Kam Man, Batinic-Haberle, Ines, Lam, Paula YP

“…Glioblastoma multiforme is the most malignant tumor of the brain and is challenging to treat due to its highly invasive nature and heterogeneity. Malignant…”
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