Prevalence and genotype distribution of JC polyomavirus in urine from patients with hematological malignancies in Vietnam

Prevalence and genotype distribution of JC polyomavirus in urine from patients with hematological malignancies in Vietnam

JC virus (JCV) causes progressive multifocal leukoencephalopathy in immunocompromised patients. The prevalence and genotype patterns of JCV vary between different geographical regions. This study was done to investigate the prevalence and genotype distribution of JCV in patients with hematological m...

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Bibliographic Details
Published in:Journal of medical virology Vol. 93; no. 8; pp. 5193 - 5198
Main Authors: Bang, Nguyen V., Xuan, Nguyen T., Trung, Ngo D., Thu, Nguyen T., Nam, Nguyen Q., Hai, Vu A., Hang, Dinh T. T., Quyen, Le T. B., Thuong, Luong T. H., Lam, Ngo Q., Thong, Nguyen H., Phuong, Nguyen M., Linh, Nguyen T., Tu, Hoang V., Cuong, Le M., Su, Hoang X.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-08-2021
Subjects:
Deoxyribonucleic acid
DNA
Genotype & phenotype
Genotypes
Genotyping
hematological malignancies
Hematology
Immunocompromised hosts
JCV: JC virus
Leukoencephalopathy
Phylogeny
Polymerase chain reaction
Progressive multifocal leukoencephalopathy
Sequence analysis
Urine
Virology
Viruses
Vietnam
hematological malignancies
genotypes
JCV: JC virus
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Summary:JC virus (JCV) causes progressive multifocal leukoencephalopathy in immunocompromised patients. The prevalence and genotype patterns of JCV vary between different geographical regions. This study was done to investigate the prevalence and genotype distribution of JCV in patients with hematological malignancies in Vietnam. A total of 48 urine samples were collected from patients with hematological malignancies. DNA was extracted and detection of JCV was by nested‐polymerase chain reaction. Sequence analysis was obtained and a phylogenetic tree was constructed for genotyping of JCV. Twenty‐seven (56.25%) urine samples tested positive for JCV. JCV genotype 7 was only observed in this study. Subtype analysis showed that JCV subtype 7A was the most commonly prevalent, followed by 7B1 and 7C1. Other subtypes were not detected in this population. There were no significant differences associated with age, gender, and biochemical parameters between patients with JCV and without JCV excretion in urine. The present study showed a high prevalence of JCV in the urine of patients with hematologic malignancies. The most common genotype found in this population was JCV subtype 7A.
Bibliography:Nguyen Van Bang, Nguyen Thanh Xuan, Ngo Dinh Trung, contributed equally to this study and share as cofirst authors.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.27078